Browse_each

Basic information

CohesinDB ID: CDBP00420191

Locus: chr21-41925348-41930095

Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE25021, ENCSR000EDW, ENCSR917QNE, GSE93080, ENCSR000DZP, GSE67783, GSE86191, GSE206145-NatGen2015, GSE135093, GSE120943, ENCSR338DUC, GSE98367, ENCSR000BLS, GSE206145, GSE62063, ENCSR167MTG, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE50893, GSE73207

Cell type: GM2610, Liver, HuCC-T1, B-cell, RPE, Fibroblast, GM12890, IMR-90, K-562, SNYDER, Monocytes, TF-1, GM12878, GM12891, GM19239, RT-112, Macrophage, Ramos, MCF-7, GM12892, HCT-116, Hep-G2, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 12% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.744

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: non-CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 35%, "5_TxWk": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, PGR, HMG20A, SOX2, XBP1, FOXA1, RBFOX2, PBX2, RXRB, MLL4, KDM3A, TFAP4, HDGF, LYL1, ZNF90, ATF3, NFIC, THRB, ZFP64, BMI1, RUNX3, CHD7, PRDM1, CBFB, MXD4, MECOM, SMARCE1, PAX5, TP63, ZNF736, ZNF467, JMJD1C, MAF, KLF5, TEAD1, BCLAF1, ZNF121, KLF6, ETV1, ELF1, TRIM28, RCOR2, ESR1, HNF1B, LMO2, SNAI2, MLL, OCA2, USF2, CTCF, TCF12, JUN, EP300, BAF155, SND1, LMO1, MNT, SOX5, GATA6, DPF2, RYBP, SOX4, DMAP1, IRF4, CREB3, SOX6, RAD51, ZNF528, TEAD4, FOXA3, ZNF175, KMT2B, GATAD2A, GTF2F1, TFAP2C, EED, RBPJ, MLX, POU2F2, CHD8, NANOG, MYCN, POU5F1, CDK7, RUNX1T1, ID3, CTBP1, MTA2, ZBTB17, ZBTB48, DUX4, STAT1, ZNF317, ZSCAN5A, MLLT3, GATAD1, SAP130, NBN, ARID3A, DDX5, TBP, HNF4G, ERG, CHD4, PBX1, ZNF597, ETS1, MYC, SMARCA4, HOMEZ, RAD21, ARID1B, GRHL3, RXRA, NKX2-1, MCRS1, GABPA, STAT3, ZNF614, XRCC5, NKX3-1, PRDM14, IKZF1, MIER3, RCOR1, NR2F6, CD74, VDR, NR3C1, CEBPB, ESRRA, SRSF3, KMT2A, CREB1, EZH2, TBL1XR1, GRHL2, ZNF652, EBF3, GABPB1, ZHX2, SPI1, ZNF786, MIXL1, TFE3, EHF, IRF1, HES1, HDAC2, GATA2, INTS13, ZNF644, GATAD2B, FLI1, DRAP1, ZGPAT, SMARCA5, ZNF766, RELB, NFIL3, NCOA2, ATF1, ETV5, RUNX1, THAP11, BCL6, SMC1A, CEBPA, NKX2-2, EZH2phosphoT487, HDAC1, SOX13, ZFX, SIN3A, MTA3, SMAD3, PCBP2, TET2, ERG3, TBX3, SP5, KLF13, TRIM22, SMARCC1, MEF2A, RARA, ZNF384, NOTCH1, CREBBP, IRF2, ZBTB2, RUNX2, GATA4, ARNT, BACH1, ZNF48, PRDM9, SMAD4, ATF2, ZEB2, FOXM1, MAFB, PBX3, SUPT5H, CDK8, HMGXB4, CHD1, ETV6, MED1, CBFA2T3, FOS, ZEB1, TEAD3, TERF1, MYB, PIAS1, ZMYM3, ZNF3, EVI1, ZNF22, KLF16, RBM22, MAFK, BCL11A, SP1, USF1, HNF4A, NR4A1, NIPBL, IKZF5, REST, ZBTB7A, RBM25, ATF7, ASH2L, HOXA9, HNRNPLL, TCF3, FOXP1, BCOR, STAG1, MLLT1, ETV4, NFATC3, SKI, MEF2B, PPARG, ZNF207, FOXA2, EBF1, MEIS1, CREM, RBBP5, MIER2, E2F8, GTF2B, WT1, ZBED1, CHD2, MEF2C, TCF7, CDK9, HOXB13, ZNF580, BCL3, KDM1A, YY1, RELA, ZNF502, TARDBP, NEUROD1, JUNB, SP140, TCF4, SKIL, HIF1A, OTX2, GATA3, BHLHE22, BATF, TAL1, MAF1, MAX, NRIP1, ZNF143, AGO2, GATA1, MTA1, SPIB, TLE3, CEBPG, KLF4, BCL11B, NCOA3, NR2F2, GFI1B, NR2F1, TCF7L2, KDM5B, ZNF687, PKNOX1, TP53, MED, ZNF334, MYOD1, BRD2, ELF3, PHF5A, KAT8, TBX21, BHLHE40, AR, ARID4B, NFKBIZ, TAF1, ZBTB40, ZBTB16, PAX3-FOXO1, EGR1, RB1, HEXIM1, ZBTB26, HSF1, NOTCH3, BRD4, IKZF2, SCRT1, RNF2, NCOR1, MAZ, AHR

Target gene symbol (double-evidenced CRMs): MX1,ABCG1,HSF2BP,UMODL1,C2CD2,PRDM15

Function elements

Human SNPs: .

Number of somatic mutations (coding): 41

Number of somatic mutations (non-coding): 17

Related genes and loops

Related gene: ENSG00000157601, ENSG00000141956, ENSG00000157617, ENSG00000177398, ENSG00000160179, ENSG00000160207,

eachgene

Deatailed information for cohesin site CDBP00420191