- Basic information
- CohesinDB ID: CDBP00420192
- Locus: chr21-41930445-41934884
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE105028, GSE121355, GSE103477, GSE131606, ENCSR330ELC, ENCSR000EDW, GSE25021, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, GSE115602, GSE165895, GSE143937, GSE67783, ENCSR000BKV, GSE115250, GSE138405, GSE86191, GSE76893, GSE101921, GSE135093, GSE206145-NatGen2015, GSE120943, GSE138105, ENCSR199XBQ, ENCSR703TNG, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR193NSH, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR000ECE, ENCSR247LSH, ENCSR000BMY, ENCSR000EHX, ENCSR807WAC, ENCSR767DFK, GSE85526, GSE206145, ENCSR495WGO, ENCSR984DZW, GSE97394, ENCSR217ELF, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, GSE110061, GSE129526, ENCSR000HPG, ENCSR676MJK, GSE111913, ENCSR054FKH, ENCSR537EFT, ENCSR153HNT, GSE68388, GSE50893, ENCSR748MVX, ENCSR481YWD, GSE73207
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Cell type: MDM, GM10847, GM2610, SLK, GM19240, Liver, Transformed-RPE1, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, TF-1, GM12878, GM12891, GM2588, SK-N-SH, GM19239, RT-112, GM19193, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, MCF-10A, Hep-G2, A-549, HUVEC, HCAEC, GM19238, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 48% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.456
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 36%,
"7_Enh": 35%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, HMG20A, SOX2, XBP1, FOXA1, HLF, RXRB, SMAD1-5, PBX2, ZFHX2, KDM3A, TFAP4, UBTF, SIN3B, HDGF, LYL1, ATF3, NFIC, ZC3H8, ZFP64, THAP1, CTCFL, CHD7, CBFB, MXD4, SMARCE1, PAX5, TP63, SFPQ, CDX2, ZNF467, JMJD1C, KLF5, TEAD1, TRIM28, ELF1, KLF6, SNAI2, NFE2L2, RBM39, RCOR2, LMO2, OCA2, TP73, ESR1, ETV1, JUN, CTCF, TCF12, EP300, BAF155, KLF1, SOX9, GATA6, SOX5, PAX8, SOX4, DPF2, DMAP1, SOX6, E2F4, ZNF423, E2F1, ZNF528, SMC1, TEAD4, FOXA3, ZNF175, GATAD2A, TFAP2C, EED, RBPJ, MLX, NANOG, CHD8, POU2F2, ZSCAN5D, MYCN, ZNF263, RUNX1T1, ID3, TOP2A, CTBP1, ERF, MTA2, ZBTB48, DUX4, STAT1, SRF, GATAD1, SAP130, ERG2, SP4, TBP, HNF4G, HOXC5, ERG, SMARCC2, ETS1, MYC, EZH1, SMARCA4, ONECUT1, ARID1B, RAD21, HOMEZ, GRHL3, PROX1, NKX2-1, MCRS1, GABPA, STAT3, APC, ZNF614, XRCC5, NKX3-1, IKZF1, RCOR1, DNMT3B, MIER3, NR2F6, VDR, NFE2, ZNF750, CEBPB, NR3C1, HNRNPH1, HNRNPL, ESRRA, KMT2A, CREB1, TBL1XR1, EZH2, BMPR1A, GRHL2, ZNF652, EBF3, TRPS1, GABPB1, ZHX2, HES1, SPI1, MIXL1, EHF, TFE3, IRF1, HDAC2, GATA2, SSRP1, ZNF644, INTS13, MXD3, ZSCAN29, SIX2, FLI1, DRAP1, ZGPAT, HCFC1, MXI1, HCFC1R1, NFIL3, NCOA2, ATF1, ETV5, PTBP1, RUNX1, THAP11, BCL6, SMC1A, CEBPA, HDAC1, LDB1, CBX1, SIN3A, ZFX, SOX13, FIP1L1, AFF4, SMAD3, ZNF770, ERG3, TBX3, TRIM22, ZMIZ1, SMARCC1, ZBTB2, PRPF4, RARA, IRF2, ZNF384, CREBBP, RUNX2, CDK6, GATA4, NRF1, DAXX, PBX4, ARNT, ATF2, ZNF48, HMBOX1, ZEB2, SMAD4, PBX3, CBFA2T3, FOS, CDK8, CHD1, HMGXB4, SMARCB1, MED1, ICE2, TEAD3, DIDO1, CEBPD, ZEB1, MYB, ZMYM3, SMAD1, PIAS1, SCRT2, NR1H2, NCOA1, EVI1, MBD1, KLF16, RBM22, MAFK, NIPBL, SP1, BCL11A, HNF4A, NR4A1, TFAP2A, GSPT2, IKZF5, REST, ZBTB7A, ARID1A, CCNT2, ATF7, ASH2L, HNRNPLL, PHIP, TCF3, FOXP1, MBD2, SMC3, ELL2, STAG1, STAG2, ETV4, SKI, TRP47, CBFA2T2, PPARG, FOXA2, MTA3, CREM, RBBP5, PAF1, CHD2, MIER2, GTF2B, WT1, ESR2, ZNF574, ZNF580, BCL3, ZKSCAN1, KDM1A, YY1, RELA, HOXB13, JUNB, NEUROD1, SP140, ZFP36, HIF1A, TCF4, ZIC2, GATA3, TAL1, MAX, NRIP1, GATA1, ZNF143, MTA1, HAND2, TLE3, KLF4, CEBPG, GFI1B, NR2F2, NCOA3, TCF7L2, NR2F1, KDM5B, TP53, NFKB1, EGR2, PHF5A, ELF3, KAT8, ARRB1, BRD2, ARID4B, AR, BHLHE40, NFKBIZ, ZBTB16, EGLN2, ZBTB26, HSF1, RNF2, BRD4, JUND, ILF3, MYNN, CUX1, MAZ, NOTCH3, SCRT1, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): MX1,HSF2BP,UMODL1,ABCG1,PRDM15,C2CD2
- Function elements
- Human SNPs: Plateletcrit
- Number of somatic mutations (coding): 28
- Number of somatic mutations (non-coding): 2
- Related genes and loops
- Related gene:
ENSG00000157601,
ENSG00000141956,
ENSG00000157617,
ENSG00000177398,
ENSG00000160179,
ENSG00000160207,
- Related loop:
chr21:41425000-41450000~~chr21:41925000-41950000,
chr21:41600000-41625000~~chr21:41925000-41950000,
chr21:41775000-41800000~~chr21:41925000-41950000,
chr21:41815787-41818293~~chr21:41931609-41933343,
chr21:41925000-41950000~~chr21:42075000-42100000,
chr21:41925000-41950000~~chr21:42100000-42125000,
chr21:41925000-41950000~~chr21:42250000-42275000,
chr21:41925000-41950000~~chr21:43300000-43325000,
chr21:41925000-41950000~~chr21:43575000-43600000,
chr21:41931617-41935016~~chr21:42116717-42118997,
chr21:41931627-41934942~~chr21:42106891-42109246,
chr21:41931627-41934942~~chr21:42116645-42118612,
chr21:41931641-41934899~~chr21:42116704-42118362,
chr21:41931667-41934991~~chr21:42106648-42108930,
chr21:41931667-41934991~~chr21:42116635-42118386,
chr21:41931668-41934949~~chr21:42116674-42118422,
chr21:41931678-41934978~~chr21:42116708-42118415,
chr21:41931733-41935274~~chr21:42116276-42118975,
chr21:41931738-41935261~~chr21:42116256-42118602,
chr21:41933026-41935331~~chr21:42116759-42118352,
chr21:41933042-41935253~~chr21:42116707-42118594,
chr21:41933531-41934760~~chr21:42116715-42119049,