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Basic information

CohesinDB ID: CDBP00420193

Locus: chr21-41935426-41935789

Data sourse: GSE206145, GSE206145-NatGen2015, GSE67783, ENCSR153HNT

Cell type: K-562, Fibroblast, HSPC, RPE

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 56%, "15_Quies": 33%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, HMG20A, SOX2, XBP1, FOXA1, HLF, RXRB, SMAD1-5, PBX2, ZFHX2, KDM3A, TFAP4, UBTF, SIN3B, HDGF, LYL1, ATF3, NFIC, ZC3H8, ZFP64, THAP1, CTCFL, CHD7, CBFB, MXD4, SMARCE1, PAX5, TP63, SFPQ, CDX2, ZNF467, JMJD1C, KLF5, TEAD1, TRIM28, ELF1, KLF6, SNAI2, NFE2L2, RBM39, RCOR2, LMO2, OCA2, TP73, ESR1, ETV1, JUN, CTCF, TCF12, EP300, BAF155, KLF1, SOX9, GATA6, SOX5, PAX8, SOX4, DPF2, DMAP1, SOX6, E2F4, ZNF423, E2F1, ZNF528, SMC1, TEAD4, FOXA3, ZNF175, GATAD2A, TFAP2C, EED, RBPJ, MLX, NANOG, CHD8, POU2F2, ZSCAN5D, MYCN, ZNF263, RUNX1T1, ID3, TOP2A, CTBP1, ERF, MTA2, ZBTB48, DUX4, STAT1, SRF, GATAD1, SAP130, ERG2, SP4, TBP, HNF4G, HOXC5, ERG, SMARCC2, ETS1, MYC, EZH1, SMARCA4, ONECUT1, ARID1B, RAD21, HOMEZ, GRHL3, PROX1, NKX2-1, MCRS1, GABPA, STAT3, APC, ZNF614, XRCC5, NKX3-1, IKZF1, RCOR1, DNMT3B, MIER3, NR2F6, VDR, NFE2, ZNF750, CEBPB, NR3C1, HNRNPH1, HNRNPL, ESRRA, KMT2A, CREB1, TBL1XR1, EZH2, BMPR1A, GRHL2, ZNF652, EBF3, TRPS1, GABPB1, ZHX2, HES1, SPI1, MIXL1, EHF, TFE3, IRF1, HDAC2, GATA2, SSRP1, ZNF644, INTS13, MXD3, ZSCAN29, SIX2, FLI1, DRAP1, ZGPAT, HCFC1, MXI1, HCFC1R1, NFIL3, NCOA2, ATF1, ETV5, PTBP1, RUNX1, THAP11, BCL6, SMC1A, CEBPA, HDAC1, LDB1, CBX1, SIN3A, ZFX, SOX13, FIP1L1, AFF4, SMAD3, ZNF770, ERG3, TBX3, TRIM22, ZMIZ1, SMARCC1, ZBTB2, PRPF4, RARA, IRF2, ZNF384, CREBBP, RUNX2, CDK6, GATA4, NRF1, DAXX, PBX4, ARNT, ATF2, ZNF48, HMBOX1, ZEB2, SMAD4, PBX3, CBFA2T3, FOS, CDK8, CHD1, HMGXB4, SMARCB1, MED1, ICE2, TEAD3, DIDO1, CEBPD, ZEB1, MYB, ZMYM3, SMAD1, PIAS1, SCRT2, NR1H2, NCOA1, EVI1, MBD1, KLF16, RBM22, MAFK, NIPBL, SP1, BCL11A, HNF4A, NR4A1, TFAP2A, GSPT2, IKZF5, REST, ZBTB7A, ARID1A, CCNT2, ATF7, ASH2L, HNRNPLL, PHIP, TCF3, FOXP1, MBD2, SMC3, ELL2, STAG1, STAG2, ETV4, SKI, TRP47, CBFA2T2, PPARG, FOXA2, MTA3, CREM, RBBP5, PAF1, CHD2, MIER2, GTF2B, WT1, ESR2, ZNF574, ZNF580, BCL3, ZKSCAN1, KDM1A, YY1, RELA, HOXB13, JUNB, NEUROD1, SP140, ZFP36, HIF1A, TCF4, ZIC2, GATA3, TAL1, MAX, NRIP1, GATA1, ZNF143, MTA1, HAND2, TLE3, KLF4, CEBPG, GFI1B, NR2F2, NCOA3, TCF7L2, NR2F1, KDM5B, TP53, NFKB1, EGR2, PHF5A, ELF3, KAT8, ARRB1, BRD2, ARID4B, AR, BHLHE40, NFKBIZ, ZBTB16, EGLN2, ZBTB26, HSF1, RNF2, BRD4, JUND, ILF3, MYNN, CUX1, MAZ, NOTCH3, SCRT1, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): UMODL1,C2CD2,HSF2BP,ABCG1,MX1,PRDM15

Function elements

Human SNPs: .

Number of somatic mutations (coding): 1

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000157601, ENSG00000141956, ENSG00000157617, ENSG00000177398, ENSG00000160179, ENSG00000160207,

eachgene

Deatailed information for cohesin site CDBP00420193