- Basic information
- CohesinDB ID: CDBP00420196
- Locus: chr21-41942461-41944496
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Data sourse: GSE206145-GSE177045, GSE67783, GSE86191, GSE111913, GSE206145, GSE206145-NatGen2015, ENCSR153HNT
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Cell type: MCF-7, RPE, Fibroblast, HCT-116, RT-112, K-562, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.922
- Subunit: SA1,Rad21,SMC1,SA2,Mau2
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 51%,
"15_Quies": 27%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, GLIS1, PGR, BCL6, BRD1, SMC1A, MYCN, ZNF263, RUNX1T1, KDM4C, ZFX, SIN3A, MEIS2, MEIS1, ZBTB48, ZSCAN5A, WT1, FOXA1, XBP1, TET2, ETV5, YY1, RELA, AHR, MYC, SP140, GRHL3, TOP2A, ZNF143, FOS, NR3C1, ELF1, ZNF573, KMT2A, NFE2L2, KDM5B, ESR1, OCA2, CTCF, RBM22, JUN, ZHX2, AR, RXR, ZBTB26, HSF1, HOXA9, MAZ, SMC3, POU2F2, STAG1, TFAP2C
- Target gene symbol (double-evidenced CRMs): C2CD2,UMODL1,HSF2BP,ABCG1,PRDM15,MX1
- Function elements
- Human SNPs: Gut_microbiota_(bacterial_taxa,_rank_normal_transformation_method)
- Number of somatic mutations (coding): 13
- Number of somatic mutations (non-coding): 13
- Related genes and loops
- Related gene:
ENSG00000157601,
ENSG00000141956,
ENSG00000157617,
ENSG00000177398,
ENSG00000160179,
ENSG00000160207,
- Related loop:
chr21:41425000-41450000~~chr21:41925000-41950000,
chr21:41600000-41625000~~chr21:41925000-41950000,
chr21:41775000-41800000~~chr21:41925000-41950000,
chr21:41925000-41950000~~chr21:42075000-42100000,
chr21:41925000-41950000~~chr21:42100000-42125000,
chr21:41925000-41950000~~chr21:42250000-42275000,
chr21:41925000-41950000~~chr21:43300000-43325000,
chr21:41925000-41950000~~chr21:43575000-43600000,