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Basic information

CohesinDB ID: CDBP00420198

Locus: chr21-41947715-41949276

Data sourse: ENCSR000EFJ, GSE206145-GSE177045, GSE67783, GSE86191, GSE131577, GSE206145, GSE101921, GSE206145-NatGen2015, ENCSR153HNT, GSE165895

Cell type: MCF-7, RPE, Fibroblast, HL-60, HCT-116, HCAEC, IMR-90, K-562, HSPC, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 7% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.889

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 38%, "5_TxWk": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, SOX2, FOXA1, HLF, RBFOX2, ATF3, NFIC, ZNF362, THAP1, CHD7, ZNF467, RBM39, SNAI2, ESR1, CTCF, TCF12, JUN, EP300, SOX4, E2F1, ZNF528, SMC1, FOXA3, GATAD2A, TFAP2C, RBPJ, NANOG, POU2F2, BRD1, ZNF263, MYCN, ZBTB48, SAP130, ERG2, OGG1, MYC, HOMEZ, RAD21, RXRA, NKX2-1, STAT3, NKX3-1, IKZF1, RCOR1, DNMT3B, NR2F6, VDR, NR3C1, CEBPB, SPI1, GATA2, ZNF644, MXD3, FLI1, MXI1, NFIL3, RUNX1, SMC1A, BCL6, ZFX, TWIST1, RARA, ZNF384, RUNX2, ARNT, PBX4, SOX11, SMAD4, PBX3, FOS, MED1, TEAD3, ZNF22, RBM22, BCL11A, HNF4A, REST, ZBTB7A, AATF, STAG1, TRP47, ZNF283, PPARG, FOXA2, WT1, ZNF580, RELA, NEUROD1, SP140, OTX2, GATA3, TAL1, MAX, AGO2, TLE3, NR2F2, NEUROG2, NR2F1, KDM5B, EGR2, ARID4B, AR, HSF1, ZBTB26, IKZF2, BRD4, JUND, MAZ, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): C2CD2,ABCG1,MX1,UMODL1,HSF2BP,PRDM15

Function elements

Human SNPs: .

Number of somatic mutations (coding): 3

Number of somatic mutations (non-coding): 3

Related genes and loops

Related gene: ENSG00000157601, ENSG00000141956, ENSG00000157617, ENSG00000177398, ENSG00000160179, ENSG00000160207,

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Deatailed information for cohesin site CDBP00420198