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Basic information

CohesinDB ID: CDBP00420199

Locus: chr21-41950243-41951395

Data sourse: GSE67783, GSE86191, GSE126634, GSE105028, GSE206145-NatGen2015, GSE206145, ENCSR153HNT

Cell type: RPE, Fibroblast, HCT-116, HSPC, K-562, HAP1, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.922

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: non-Boundary

Chromatin hubs: non-Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 35%, "7_Enh": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, THAP1, MORC2, PAX5, TEAD1, ZNF121, LMO2, OCA2, MED26, HDAC8, E4F1, SOX5, ZNF407, E2F4, DEK, ZNF410, ZNF528, NR5A2, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, BRD3, CTBP1, ERF, DUX4, STAT1, ZNF488, SAP130, ERG, SMARCA4, RFX1, TOP1, DNMT1, ZNF8, UBN1, ZNF398, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, GATA2, ZNF644, MXD3, FLI1, HCFC1, MXI1, DRAP1, ZNF785, NR2C2, RELB, EP400, RUNX1, HDAC1, CEBPA, ZNF707, CRY1, TET2, SP5, MCM2, TRIM22, SMARCC1, ZBTB2, ZXDC, FOXM1, SMARCB1, GMEB1, TERF1, PML, PIAS1, SMAD1, NR1H2, C11orf30, EVI1, MBD1, STAT5A, GSPT2, IKZF5, ARID2, AFF1, MBD2, ELL2, HMGB1, ETV4, NFATC3, CBFA2T2, CBX3, ZNF207, CREM, CHD2, NFATC1, SS18, PAF1, BRF2, WT1, CREB3L1, NEUROD1, JUNB, MCM3, ZFP36, ZNF311, MAF1, PLAG1, KLF4, BCL11B, ZNF544, IRF5, ZBTB6, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, HSF1, NCOR1, ZBTB26, SCRT1, ILF3, ZNF316, FOSL1, SMARCA2, ZNF621, XBP1, HNF1A, KDM4B, PBX2, HNRNPK, ATF3, THRB, ZFP64, RUNX3, WDHD1, CBFB, TP63, ZSCAN4, BACH2, CDC5L, INTS11, JMJD1C, ELF1, ZNF573, RBM39, SNAI2, SMAD5, FUS, CTCF, TAF3, JUN, MNT, ZBTB20, RYBP, DPF2, IRF4, ZNF423, ZNF280A, PDX1, TFAP2C, RBPJ, MLX, YBX1, ZNF239, MTA2, ZSCAN21, ZBTB48, NONO, SRF, DDX5, NBN, PHB2, TRIP13, KDM4A, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, LEF1, TEAD2, VDR, NR3C1, ESRRA, KMT2A, ZBTB11, CCAR2, TBL1XR1, ARHGAP35, GRHL2, EBF3, SSRP1, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, EZH2phosphoT487, LDB1, SOX13, AFF4, POU4F2, ZNF770, ZMIZ1, ZNF18, ARNT, DAXX, BACH1, NFIB, ZNF48, PRDM9, ZEB2, PBX3, NCAPH2, HMGXB4, TEAD3, ZNF670, U2AF1, KLF9, USF1, BCL11A, SP1, TFAP2A, ATF7, ASH2L, CTBP2, GLIS2, SMC3, STAG1, MLLT1, STAG2, TRP47, SAFB, AGO1, MTA3, EBF1, MEIS1, MAFF, ESR2, ZNF580, BCL3, ZKSCAN1, KDM1A, ISL1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, AGO2, MTA1, TP53, ZNF645, NFKB1, PHF5A, BRD2, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, SPIN1, JUND, CUX1, ZSCAN23, IRF9, SMAD4.1D12, PGR, SOX2, PATZ1, RING1B, UBTF, SMAD1-5, TFAP4, SIN3B, BMI1, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, KLF6, MCM7, NFE2L2, SAP30, ESR1, ZNF217, KLF1, SOX9, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZBTB1, ASH1L, ZSCAN5A, SP4, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, INO80, SRSF3, YBX3, EZH2, ZNF652, NFE2L1, PHF8, SPI1, PCBP1, HDAC2, INTS13, GATAD2B, NCOA2, ETV5, BCL6, SIN3A, ERG3, NFXL1, MEF2A, MYBL2, RARA, CREBBP, NFYC, TAF15, ZNF169, ZNF280C, SMAD4, CBFA2T3, CDK8, CSNK2A1, ZEB1, ZMYM3, SUPT16H, NCOA1, RBM22, MAFK, HNF4A, REST, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, PPARG, TBL1X, HDAC6, GTF2B, ZNF662, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, NEUROG2, PKNOX1, MYOD1, AR, ZBTB16, YAP1, HEXIM1, DMAP1, AHR, MBD3, FOSL2, HMG20A, E2F7, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, ZNF90, NFIC, CTCFL, ZBTB5, MECOM, ZNF736, CDX2, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, MLL, HNF1B, USF2, ZFP91, TCF12, BAF155, EP300, GATA6, GLI4, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, SRC, RUNX1T1, ID3, CDK7, ZNF649, GATAD1, GMEB2, ARID3A, ASCL1, MIER1, EOMES, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, ZNF639, ARNTL, ZNF750, TRPS1, HES1, TFE3, EHF, HBP1, IRF1, ZGPAT, MRTFB, MYF5, ATF1, PTBP1, SMC1A, CBX1, MAFG, SIRT6, FIP1L1, ZFX, ZNF534, SMAD3, NMYC, TWIST1, NSD2, NOTCH1, BRD9, RUNX2, CDK6, GATA4, OSR2, ZNF184, GR, NRF1, PBX4, NR2C1, CHD1, FOS, SUPT5H, MED1, CEBPD, MYB, KDM6B, VEZF1, ZNF3, L3MBTL2, SETDB1, NIPBL, PHF20, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, SALL1, SKI, PAX7, NCOA4, KLF13, FOXA2, RBBP5, MIER2, ZBTB33, CDK9, HOXB13, YY1, ZNF148, SP140, HIF1A, OTX2, GATA1, TLE3, CEBPG, NCOA3, NR2F2, ZNF687, BHLHE40, NFKBIZ, TAF1, ZNF579, ZBTB40, MYNN, MAZ, MEF2D, ZNF24

Target gene symbol (double-evidenced CRMs): C2CD2,UMODL1,SLC37A1,RSPH1,ABCG1,PRDM15,BACE2,UBASH3A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 2

Number of somatic mutations (non-coding): 2

Related genes and loops

Related gene: ENSG00000182240, ENSG00000141956, ENSG00000157617, ENSG00000177398, ENSG00000160179, ENSG00000160185, ENSG00000160188, ENSG00000160190,

eachgene

Deatailed information for cohesin site CDBP00420199