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Basic information

CohesinDB ID: CDBP00420203

Locus: chr21-41964196-41969097

Data sourse: GSE206145-GSE177045, GSE72082, GSE25021, ENCSR000BUC, GSE165895, ENCSR000BTU, GSE93080, GSE143937, GSE67783, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, GSE130135, ENCSR703TNG, ENCSR193NSH, ENCSR879KXD, GSE206145, ENCSR000BTQ, GSE111913, ENCSR153HNT, GSE50893

Cell type: GM2610, RPE, GM2630, Fibroblast, Ishikawa, GM12890, K-562, GM18486, HFFc6, GM12878, GM2588, GM19239, RT-112, MCF-7, GM12892, Hela-Kyoto, HCT-116, HEK293T, A-549, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 16% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.767

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: non-Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 31%, "14_ReprPCWk": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, E2F7, SOX2, MEIS2, PATZ1, FOXA1, SUZ12, PBX2, RXRB, ZFHX2, ZNF90, ATF3, NFIC, ZNF362, THAP1, CHD7, ZBTB44, IKZF3, CBFB, MXD4, ZNF189, TP63, ZNF629, JMJD1C, KLF5, TEAD1, ZNF121, ZNF573, ELF1, TRIM28, NFE2L2, LMO2, ESR1, OCA2, ZNF217, USF2, ZNF561, ZFP91, JUN, ZNF507, CTCF, BAF155, TCF12, EP300, MNT, KLF1, SOX5, PAX8, DPF2, DMAP1, TRIM24, ZNF423, E2F1, SMC1, ZNF350, TEAD4, KMT2B, GATAD2A, EHMT2, TFAP2C, RBPJ, GLIS1, POU2F2, NANOG, CHD8, ZSCAN5D, MYCN, POU5F1, TOP2A, ZNF263, BRD3, CTBP1, ZSCAN21, ZBTB17, ZBTB48, ZSCAN5A, ID3, ZNF317, DDX5, ERG2, HOXC5, ERG, ZBTB8A, ETS1, MYC, EZH1, SMARCA4, ZNF341, ARID1B, RAD21, FOXP2, EOMES, GRHL3, RXRA, NKX2-1, STAT3, XRCC5, ZNF614, NKX3-1, PRDM14, APC, RCOR1, HNRNPH1, NR2F6, ZNF639, VDR, NR3C1, CEBPB, ESRRA, SRSF3, KMT2A, CREB1, EZH2, KLF8, BMPR1A, GRHL2, GABPB1, PHF8, SPI1, HDAC2, GATA2, ZNF644, GATAD2B, MXD3, ZNF146, SIX2, FLI1, MXI1, ZNF789, HCFC1R1, NFIL3, NCOA2, ZNF554, ZNF76, NFYB, ATF1, ETV5, RUNX1, BCL6, SMC1A, CEBPA, CBX1, EZH2phosphoT487, SIN3A, ZFX, SOX13, ZNF335, POU4F2, SMAD3, TET2, CBX8, ERG3, ZNF770, ZNF18, PRDM10, RARA, ZBTB2, CREBBP, ZXDC, ZNF35, ZNF384, RUNX2, GATA4, OSR2, PBX4, DAXX, ARNT, NFIB, ZNF48, PRDM9, ATF2, ZEB2, SMAD4, FOXM1, ETV6, SP2, FOS, CDK8, MED1, ZEB1, TEAD3, ZNF264, ZXDB, SCRT2, PIAS1, MYB, SUPT16H, ZNF3, ZMYM3, KLF9, L3MBTL2, SETDB1, ZNF22, MAFK, NIPBL, TFAP2A, USF1, BCL11A, IKZF5, REST, ZBTB7A, RBM25, ATF7, CTBP2, PCGF2, TCF3, FOXP1, GLIS2, PHIP, SMC3, STAG1, CBFA2T2, MEF2B, ZNF316, FOXA2, PPARG, EBF1, ZNF600, ZNF692, WT1, MAFF, HOXB13, ZNF580, KDM1A, YY1, RELA, JUNB, NEUROD1, MCM3, SP140, ZFP36, ZIC2, HIF1A, GATA3, BATF, TAL1, MAX, NRIP1, ZNF143, GATA1, CBX2, TLE3, ZNF223, SP7, GFI1B, NR2F2, NEUROG2, NR2F1, TP53, PKNOX1, ZNF334, NFKB1, ZSCAN22, EGR2, BRD2, ELF3, BHLHE40, AR, TAF1, ZNF324, HSF1, RNF2, ZBTB26, BRD4, JUND, NCOR1, SCRT1, MAZ, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): UBASH3A,ABCG1,BACE2,RSPH1,UMODL1,SLC37A1,PRDM15

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 22

Related genes and loops

Related gene: ENSG00000182240, ENSG00000141956, ENSG00000177398, ENSG00000160179, ENSG00000160185, ENSG00000160188, ENSG00000160190,

eachgene

Deatailed information for cohesin site CDBP00420203