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Basic information

CohesinDB ID: CDBP00420205

Locus: chr21-41972592-41976832

Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE131606, GSE108869, ENCSR000EDW, GSE25021, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, ENCSR000DZP, GSE93080, GSE67783, GSE86191, GSE138405, GSE76893, GSE101921, GSE206145-NatGen2015, ENCSR703TNG, GSE94872, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR000BMY, GSE97394, GSE55407, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893

Cell type: MDM, RH4, GM10847, GM2610, GM19240, HSPC, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, GM18505, GM12878, GM12891, GM2588, SK-N-SH, GM19239, RT-112, GM19193, THP-1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, HUVEC, HCAEC, GM19238, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 29% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.511

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 47%, "7_Enh": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, FOSL1, PGR, HMG20A, NME2, XBP1, FOXA1, RXRB, KDM3A, HDGF, ATF3, ZFP64, THAP1, ZBTB5, CHD7, RUNX3, MXD4, TP63, JMJD1C, MAF, TEAD1, TRIM28, ELF1, KLF6, SNAI2, RBM39, RCOR2, ESR1, MLL, OCA2, SAP30, USF2, CTCF, JUN, TCF12, MNT, SOX5, DPF2, PAX8, DMAP1, E2F6, RAD51, SMC1, RFX3, TEAD4, FOXA3, KMT2B, ZNF175, GTF2F1, GATAD2A, TFAP2C, RBPJ, EED, EHMT2, CHD8, BRD1, ZSCAN5D, MYCN, POU5F1, ZNF263, RUNX1T1, CDK7, MTA2, ZBTB48, DUX4, STAT1, SRF, GATAD1, SAP130, ARID3A, ERG2, HNF4G, ERG, MIER1, ETS1, MYC, MCM5, SMARCA4, HOMEZ, RAD21, GRHL3, PROX1, RXRA, GABPA, STAT3, XRCC5, ZNF614, PRDM14, IKZF1, MIER3, DNMT3B, NR2F6, VDR, ZNF750, NR3C1, ESRRA, CEBPB, STAT5B, KMT2A, CREB1, CCAR2, EZH2, GRHL2, ZNF652, GABPB1, SPI1, HBP1, TFE3, HDAC2, INTS13, ZNF644, GATAD2B, MXD3, FLI1, DRAP1, ZGPAT, HCFC1R1, NFIL3, ETV5, RUNX1, THAP11, SMC1A, BCL6, CEBPA, LDB1, SIRT6, SOX13, ZFX, FIP1L1, SIN3A, TET2, ERG3, SMARCC1, ZBTB2, ZNF35, CREBBP, RARA, NOTCH1, NFYC, RUNX2, GATA4, ARNT, NFIB, NRF1, ZNF48, SMAD4, NR2C1, SMARCB1, FOS, CHD1, HMGXB4, CDK8, MED1, SP2, TEAD3, MYB, SCRT2, U2AF1, ZNF3, ZBTB18, L3MBTL2, SETDB1, EVI1, USF1, SP1, BCL11A, HNF4A, IKZF5, REST, ZBTB7A, ASH2L, HNRNPLL, TCF3, AATF, SMC3, STAG1, STAG2, ETV4, NFATC3, TRP47, CBFA2T2, MEF2B, PPARG, FOXA2, EBF1, MIER2, GTF2B, WT1, ZNF580, KDM1A, YY1, RELA, MCM3, SP140, HIF1A, GATA3, TAL1, MAX, NRIP1, GATA1, ZNF143, SPIB, CBX2, PLAG1, KLF4, BCL11B, CEBPG, NR2F2, NR2F1, ZNF687, TP53, ZBTB6, MED, ZNF334, T, ELF3, KAT8, BRD2, PHF5A, NFKBIZ, AR, ARID4B, BHLHE40, EGLN2, EGR1, RB1, HEXIM1, HSF1, ZBTB26, IKZF2, BRD4, RNF2, SCRT1, ZNF248, CUX1, MAZ, ZNF24, AHR

Target gene symbol (double-evidenced CRMs): UMODL1,BACE2,PRDM15,UBASH3A,RSPH1,ABCG1,SLC37A1,C2CD2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 24

Related genes and loops

Related gene: ENSG00000182240, ENSG00000141956, ENSG00000157617, ENSG00000177398, ENSG00000160179, ENSG00000160185, ENSG00000160188, ENSG00000160190,

eachgene

Deatailed information for cohesin site CDBP00420205