- Basic information
- CohesinDB ID: CDBP00420213
- Locus: chr21-42001760-42004907
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Data sourse: ENCSR000EFJ, GSE38395, GSE93080, ENCSR000EAC, ENCSR000DZP, GSE206145-GSE177045, GSE86191, GSE98367, ENCSR000HPG, ENCSR000BLY, GSE155324, GSE206145, GSE85526, GSE206145-NatGen2015, ENCSR000BMY, ENCSR000EHX, ENCSR703TNG, GSE50893, GSE165895
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Cell type: GM2610, B-cell, RPE, GM2630, Fibroblast, HEKn, GM12890, hLCL, GM2255, IMR-90, GM18486, HFFc6, GM18526, SNYDER, GM18505, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, Macrophage, MCF-7, GM12892, HCT-116, GM19238
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 15% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.711
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
94% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 44%,
"4_Tx": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, NME2, XBP1, FOXA1, RBFOX2, ZFHX2, HDGF, ATF3, NFIC, RUNX3, PRDM1, CHD7, SMARCE1, PAX5, TP63, MITF, BACH2, MAF, KLF5, ELF1, BCLAF1, TRIM28, SNAI2, NFE2L2, ZNF217, LMO2, OCA2, USF2, CTCF, TCF12, JUN, EP300, DPF2, SIX5, IRF4, RAD51, TEAD4, TFAP2C, EED, POU2F2, ZSCAN5D, BRD3, MTA2, STAT1, NBN, ARID3A, ERG2, HOXC5, ERG, ZNF597, NFKB2, MYC, RAD21, GRHL3, RXRA, NKX2-1, FOXK2, BATF3, STAT3, IKZF1, RCOR1, CD74, VDR, NR3C1, CEBPB, CREB1, EPAS1, ZHX2, SPI1, GATA2, GATAD2B, ZSCAN29, FLI1, HCFC1, MXI1, SMARCA5, RELB, MRTFB, BCL6, SMC1A, EZH2phosphoT487, AFF4, ZFX, SIN3A, SMAD3, ERG3, TRIM22, MEF2A, CREBBP, RUNX2, GATA4, OSR2, ZNF184, PBX4, ARNT, BACH1, DAXX, HMGB2, ATF2, PBX3, FOXM1, ETV6, CHD1, CDK8, FOS, MED1, ZEB1, MYB, SCRT2, ZMYM3, EVI1, STAT5A, MAFK, NIPBL, SP1, BCL11A, USF1, REST, RBM25, ATF7, ASH2L, BCOR, TCF3, SMC3, HMGB1, MLLT1, NFATC3, MEF2B, FOXA2, MTA3, EBF1, ZNF207, NFATC1, E2F8, CREM, PAF1, GTF2B, ZBED1, BCL3, KDM1A, YY1, RELA, TARDBP, JUNB, SKIL, GATA3, BATF, MAX, SPIB, GATA1, ZNF143, KLF4, SP7, NCOA3, NR2F1, ZNF687, PKNOX1, TP53, NFKB1, EGR2, PHOX2B, BRD2, TBX21, BHLHE40, AR, PAX3-FOXO1, TAF1, ZNF445, ZBTB40, RXR, ZNF366, IKZF2, SCRT1, BRD4, JUND, MAZ, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): UMODL1,ZBTB21,PRDM15,C2CD2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 36
- Number of somatic mutations (non-coding): 2
- Related genes and loops
- Related gene:
ENSG00000141956,
ENSG00000157617,
ENSG00000173276,
ENSG00000177398,
- Related loop:
chr21:41600000-41625000~~chr21:41975000-42000000,
chr21:41875000-41900000~~chr21:41975000-42000000,
chr21:41875000-41900000~~chr21:42000000-42025000,
chr21:41877545-41880451~~chr21:42008763-42011946,
chr21:41952495-41953705~~chr21:42008731-42011959,
chr21:41957072-41959223~~chr21:42008838-42011899,
chr21:41957418-41959149~~chr21:42008452-42012075,
chr21:41975000-42000000~~chr21:42075000-42100000,
chr21:42000000-42025000~~chr21:42100000-42125000,
chr21:42008409-42012026~~chr21:42106683-42108941,
chr21:42008452-42012075~~chr21:42106648-42108930,
chr21:42008727-42012041~~chr21:42106936-42108928,
chr21:42008728-42012071~~chr21:42106883-42109087,
chr21:42008730-42010862~~chr21:42116718-42118814,
chr21:42008738-42010602~~chr21:42116725-42118988,
chr21:42008738-42011645~~chr21:42106897-42108988,
chr21:42008738-42011645~~chr21:42116715-42119049,
chr21:42008738-42012043~~chr21:42106900-42108919,
chr21:42008744-42011714~~chr21:42060877-42064978,
chr21:42008744-42011714~~chr21:42106670-42109262,
chr21:42008744-42011714~~chr21:42116454-42119047,