- Basic information
- CohesinDB ID: CDBP00420214
- Locus: chr21-42005507-42006937
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, GSE105028, GSE121355, GSE25021, GSE115602, ENCSR917QNE, GSE93080, ENCSR000DZP, GSE67783, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, ENCSR703TNG, ENCSR338DUC, ENCSR000ECE, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE111913, GSE38411
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Cell type: MCF-7, H1-hESC, Fibroblast, HCT-116, Hela-Kyoto, Hep-G2, GM12878, RT-112, BCBL-1, Liver, HSPC, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 9% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.867
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
94% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 75%,
"4_Tx": 11%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, NANOG, MAFG, HDAC1, FOXA2, PAF1, ID3, ZNF600, MEIS2, FOXA1, RBFOX2, PBX2, HOXB13, ZKSCAN1, PRDM10, ERG, RELA, GATA4, SMARCA4, ARID1B, ZNF184, ARNT, HIF1A, PBX4, GATA3, STAT3, CBFA2T3, MZF1, NKX3-1, GATA1, NFE2, RCOR1, TLE3, ZFP69B, GFI1B, PIAS1, NFE2L2, C11orf30, GRHL2, SETDB1, RBM22, BAF155, AR, ZNF579, DPF2, GATA2, EGLN2, ZHX1, BRD4, PHIP, TEAD4, PDX1
- Target gene symbol (double-evidenced CRMs): PRDM15,UMODL1,ZBTB21,C2CD2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 24
- Number of somatic mutations (non-coding): 6
- Related genes and loops
- Related gene:
ENSG00000141956,
ENSG00000157617,
ENSG00000173276,
ENSG00000177398,
- Related loop:
chr21:41875000-41900000~~chr21:42000000-42025000,
chr21:41877545-41880451~~chr21:42008763-42011946,
chr21:41952495-41953705~~chr21:42008731-42011959,
chr21:41957072-41959223~~chr21:42008838-42011899,
chr21:41957418-41959149~~chr21:42008452-42012075,
chr21:42000000-42025000~~chr21:42100000-42125000,
chr21:42008409-42012026~~chr21:42106683-42108941,
chr21:42008452-42012075~~chr21:42106648-42108930,
chr21:42008727-42012041~~chr21:42106936-42108928,
chr21:42008728-42012071~~chr21:42106883-42109087,
chr21:42008730-42010862~~chr21:42116718-42118814,
chr21:42008738-42010602~~chr21:42116725-42118988,
chr21:42008738-42011645~~chr21:42106897-42108988,
chr21:42008738-42011645~~chr21:42116715-42119049,
chr21:42008738-42012043~~chr21:42106900-42108919,
chr21:42008744-42011714~~chr21:42060877-42064978,
chr21:42008744-42011714~~chr21:42106670-42109262,
chr21:42008744-42011714~~chr21:42116454-42119047,