Deatailed information for cohesin site CDBP00420215

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  • Basic information
  • CohesinDB ID: CDBP00420215
  • Locus: chr21-42007533-42014157
  • Data sourse: ENCSR230ZWH, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE38411, ENCSR000BLD, GSE64758, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE76893, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
  • Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, Ramos, GM19238, Neutrophil, GM18951
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 66% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.256
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 94% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "2_TssAFlnk": 20%, "1_TssA": 20%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, SRSF7, PAX5, TEAD1, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, ARID5B, E4F1, SOX5, PAX8, E2F4, DEK, ZNF674, ZNF528, RFX3, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, BRD3, CTBP1, ERF, DUX4, STAT1, SAP130, ERG, ZBTB21, ZNF597, ZBTB8A, EZH1, SMARCA4, RFX1, FOXK2, UBN1, ZNF398, RCOR1, NR2F6, DACH1, CEBPB, HNRNPL, RBM34, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, MXI1, HCFC1, NR2C2, RELB, EP400, RUNX1, CEBPA, HDAC1, NKX2-2, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, TFDP1, ZBTB10, ELK1, ATF2, SNIP1, SOX11, FOXM1, SP2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, C11orf30, MBD1, GSPT2, IKZF5, ARID2, RBM25, ZNF605, MBD2, ELL2, HMGB1, ETV4, NFATC3, MEF2B, ZNF207, CBX3, CREM, CHD2, PAF1, NFATC1, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, TCF4, BATF, MAF1, PLAG1, KLF4, BCL11B, ZFP69B, IRF5, ZBTB6, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, ZNF101, SRSF4, PBX2, ZNF596, HNRNPK, THRB, ATF3, ZFP64, HNRNPUL1, RUNX3, CBFB, DPF1, TP63, MITF, ZNF467, MAF, JMJD1C, INTS11, ELF1, MYOG, RBM39, SNAI2, KLF10, SMAD5, FUS, CTCF, TAF3, JUN, ZBTB20, MNT, LMO1, DPF2, RYBP, SIX5, IRF4, ZNF423, ZNF677, PDX1, TFAP2C, RBPJ, MLX, ZSCAN21, ZNF317, ZBTB17, ZBTB48, MTA2, NONO, SRF, DDX5, NBN, CHD4, ZNF2, HOMEZ, KDM4A, FOXP2, TSHZ1, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, EBF3, ZKSCAN5, KDM5A, ZBTB14, SSRP1, ZNF146, ZSCAN29, SMARCA5, NFIL3, THAP11, CIITA, CTNNB1, EZH2phosphoT487, SOX13, AFF4, POU4F2, ZNF770, ZMIZ1, ZNF18, SP3, ARNT, BACH1, NFIB, DAXX, ZNF48, ZEB2, NFYA, ETV6, NCAPH2, PBX3, HMGXB4, TEAD3, ZXDB, U2AF1, TAF7, KLF9, USF1, BCL11A, SP1, TFAP2A, NKX2-5, ATF7, ASH2L, ZNF548, CTBP2, GLIS2, SMC3, MLLT1, STAG1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, BCL3, ZKSCAN1, KDM1A, BRG1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, AGO2, MTA1, CBX2, TP53, NFKB1, ZSCAN22, PHF5A, BRD2, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, PGR, SOX2, PATZ1, LEO1, UBTF, RING1B, TFAP4, SIN3B, BMI1, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, MZF1, RLF, KLF6, NFE2L2, SAP30, ESR1, ZNF217, ZNF524, KLF1, SOX4, E2F6, TRIM24, RFX5, PRKDC, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZBTB1, ZSCAN5A, ELK4, SP4, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, ZNF343, DNMT3B, INO80, SRSF3, EZH2, ZNF652, PHF8, SPI1, ZNF202, PCBP1, HDAC2, RBP2, INTS13, GATAD2B, ZNF76, NCOA2, NFYB, ETV5, AHRR, BCL6, SIN3A, ZBTB12, ERG3, RARA, ZNF384, NFYC, CREBBP, TAF15, ZNF133, ZNF35, SMAD4, ZNF518A, CDK8, CSNK2A1, ZEB1, SUPT16H, NCOA1, SREBF2, ZNF22, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, ZNF543, BCOR, FOXP1, AATF, NCOR2, ZNF34, CXXC4, PPARG, TBL1X, HDAC6, ZNF44, ZNF692, GTF2B, JDP2, ZNF574, YY2, FOXO3, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, NEUROG2, PKNOX1, RUVBL1, MYOD1, AR, KMT2D, ZNF324, HEXIM1, DMAP1, AHR, MBD3, FOSL2, ZNF391, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, SFMBT1, ZFHX2, INSM2, NFIC, ZNF362, CTCFL, PRDM1, KLF14, MECOM, CDX2, ZNF629, ZNF506, KLF5, BCLAF1, TRIM28, ETV1, RCOR2, COBLL1, HNF1B, USF2, TCF12, EP300, BAF155, GATA6, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, CDK7, ID3, HINFP, GATAD1, GMEB2, ARID3A, USP7, ASCL1, ZNF341, RAD21, GRHL3, APC, ZNF614, XRCC5, NFE2, TCF25, ZNF639, TFE3, HBP1, IRF1, SREBF1, ZGPAT, MRTFB, ZC3H11A, ATF1, PTBP1, CBX1, MAFG, SMC1A, SIRT6, ZNF335, FIP1L1, ZFX, SMAD3, NMYC, CBX8, TWIST1, IRF2, PRPF4, NOTCH1, NCOA6, RUNX2, CDK6, GATA4, OSR2, ZNF184, ZSCAN30, PBX4, NRF1, NR2C1, FOS, CHD1, SUPT5H, TGIF2, MED1, CEBPD, KDM6B, MYB, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, ZNF783, SKI, NELFA, PAX7, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBTB33, CDK9, HOXB13, YY1, ASXL1, BRCA1, SP140, ZNF610, HIF1A, OTX2, ZNF519, ZNF740, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF512, ZNF687, ZNF213, BHLHE40, NFKBIZ, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, CLOCK, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): PRDM15,ZBTB21,C2CD2,UMODL1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 68
  • Number of somatic mutations (non-coding): 32
  • Related genes and loops
  • Related gene: ENSG00000141956, ENSG00000157617, ENSG00000173276, ENSG00000177398,
  • Related loop: chr21:41875000-41900000~~chr21:42000000-42025000, chr21:41877545-41880451~~chr21:42008763-42011946, chr21:41952495-41953705~~chr21:42008731-42011959, chr21:41957072-41959223~~chr21:42008838-42011899, chr21:41957418-41959149~~chr21:42008452-42012075, chr21:42000000-42025000~~chr21:42100000-42125000, chr21:42008409-42012026~~chr21:42106683-42108941, chr21:42008452-42012075~~chr21:42106648-42108930, chr21:42008727-42012041~~chr21:42106936-42108928, chr21:42008728-42012071~~chr21:42106883-42109087, chr21:42008730-42010862~~chr21:42116718-42118814, chr21:42008738-42010602~~chr21:42116725-42118988, chr21:42008738-42011645~~chr21:42106897-42108988, chr21:42008738-42011645~~chr21:42116715-42119049, chr21:42008738-42012043~~chr21:42106900-42108919, chr21:42008744-42011714~~chr21:42060877-42064978, chr21:42008744-42011714~~chr21:42106670-42109262, chr21:42008744-42011714~~chr21:42116454-42119047,
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