- Basic information
- CohesinDB ID: CDBP00420219
- Locus: chr21-42024136-42028162
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Data sourse: ENCSR000EFJ, GSE206145-GSE177045, GSE67783, ENCSR000BKV, GSE86191, GSE98367, ENCSR000HPG, GSE206145, GSE206145-NatGen2015, GSE120943, ENCSR153HNT, GSE68388, GSE25021, GSE165895
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Cell type: MCF-7, Macrophage, RPE, Fibroblast, HCT-116, Monocytes, IMR-90, K-562, HSPC, HuCC-T1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 6% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.878
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
94% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 27%,
"14_ReprPCWk": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, ZNF195, SOX2, ZNF621, NME2, XBP1, PATZ1, FOXA1, HLF, SUZ12, MTA2, ZFHX2, ZBTB7B, HDGF, ZNF274, ATF3, BMI1, THAP1, ZBTB5, CHD7, RUNX3, ZNF444, MORC2, SMARCE1, TP63, ZSCAN4, MITF, CDC5L, TEAD1, TRIM28, ZNF573, BCLAF1, SNAI2, NFE2L2, SAP30, ESR1, LMO2, OCA2, USF2, ZIK1, CTCF, JUN, TCF12, EP300, E4F1, LMO1, PYGO2, DPF2, E2F6, ZNF431, IRF4, TRIM24, GLI4, ZNF407, RAD51, ZNF410, ZNF512B, ZNF776, ZNF280A, TEAD4, ZNF175, GTF2F1, PDX1, RBPJ, TFAP2C, EED, GLIS1, EHMT2, YBX1, POU2F2, CHD8, BRD1, MYCN, ZNF263, TOP2A, ID3, KDM4C, POU5F1, ZNF317, ZBTB17, ZBTB48, ZSCAN5A, STAT1, ZSCAN21, ASH1L, SRF, NONO, DDX5, NBN, ERG2, PHB2, ZNF300, ERG, CHD4, ASCL1, OGG1, ZBTB8A, ETS1, MYC, MIER1, SMARCA4, RFX1, TRIP13, RAD21, MCM5, GRHL3, PROX1, RXRA, GABPA, APC, STAT3, XRCC5, NKX3-1, PRDM14, ZNF398, IKZF1, ZNF8, ZNF639, NR3C1, CEBPB, SRSF3, CTBP1, HNRNPL, KMT2A, CREB1, YBX3, EZH2, KLF8, ARHGAP35, ZNF292, GABPB1, SPI1, HES1, KLF17, IRF1, ZNF202, HDAC2, GATA2, ZNF182, ZNF644, GATAD2B, SSRP1, ZNF785, SMARCA5, ZNF766, RELB, NCOA2, ZNF554, ZNF891, SALL2, CC2D1A, RUNX1, SMC1A, BCL6, HDAC1, NKX2-2, ZNF707, CRY1, SIN3A, ZFX, POU4F2, ZNF534, CEBPA, SMAD3, TET2, CBX8, ERG3, ZNF473, NFXL1, ZNF18, CREBBP, ZBTB2, RUNX2, OSR2, ZNF184, ARNT, NFIB, SOX11, NRF1, ATF2, PRDM9, SNIP1, SMAD4, PBX3, MAFB, FOS, SUPT5H, CDK8, MED1, KDM6B, MYB, ZMYM3, KLF9, NCOA1, L3MBTL2, EVI1, USF1, SP1, BCL11A, HNF4A, NR4A1, PHF20, REST, ATF7, POU2F3, ASH2L, HNRNPLL, BCOR, FOXP1, TCF3, AATF, SMC3, STAG1, ZNF239, MLLT1, TRP47, CBFA2T2, NCOA4, MEF2B, FOXA2, TBL1X, RBBP5, MTA3, ZNF207, EBF1, ZNF600, WT1, ZNF662, ZBTB33, ZKSCAN1, BCL3, YY1, RELA, TARDBP, NEUROD1, ZNF148, ZNF266, BRG1, MCM3, SP140, ZFP36, HIF1A, ZIC2, TCF4, OTX2, ZNF311, BHLHE22, TAL1, MAX, ZNF143, ZSCAN26, PLAG1, CBX2, KLF4, ZNF592, NCOA3, NR2F2, ZNF544, NR2F1, TCF7L2, NEUROG2, ZNF791, TP53, PKNOX1, KDM5B, ZNF334, BCL6B, MYOD1, EGR2, T, BHLHE40, AR, TAF1, RXR, EGLN2, ZBTB1, HSF1, RNF2, ZBTB26, SCRT1, BRD4, JUND, CLOCK, NCOR1, MAZ, ZSCAN23, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): PRDM15,UMODL1,PDE9A,C2CD2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 18
- Related genes and loops