- Basic information
- CohesinDB ID: CDBP00420224
- Locus: chr21-42037819-42042122
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Data sourse: GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, GSE165895, ENCSR000EFJ, ENCSR917QNE, GSE67783, GSE86191, GSE76893, GSE206145-NatGen2015, GSE135093, GSE118494, ENCSR338DUC, ENCSR000BLS, GSE206145, GSE85526, ENCSR167MTG, GSE129526, ENCSR000HPG, GSE111913, ENCSR054FKH, GSE68388, GSE83726
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Cell type: MCF-7, RPE, Fibroblast, HCT-116, RH4, Hep-G2, HEKn, IMR-90, RT-112, Liver, HSPC, HuCC-T1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 15% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.856
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
94% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 37%,
"7_Enh": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, SMARCA2, HMG20A, E2F7, SOX2, XBP1, FOXA1, HLF, SUZ12, PBX2, RXRB, MLL4, SMAD1-5, KDM3A, TFAP4, ATF3, NFIC, CHD7, ATF4, CBFB, MXD4, MECOM, SMARCE1, TP63, ZNF320, ZNF467, ELF1, TRIM28, TEAD1, KLF6, RBM39, SNAI2, NFE2L2, RCOR2, ESR1, OCA2, LMO2, ETV1, USF2, JUN, CTCF, TCF12, EP300, E4F1, SOX5, PAX8, SOX4, DMAP1, E2F6, RFX5, U2AF2, E2F1, ZNF528, TEAD4, FOXA3, ZNF175, GATAD2A, GTF2F1, RBPJ, MLX, TFAP2C, GLIS1, POU2F2, CHD8, ZNF425, BRD1, MYCN, ZNF263, TOP2A, ID3, ZBTB48, STAT1, GATAD1, SAP130, ARID3A, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, ONECUT1, SMARCA4, RFX1, HOMEZ, RAD21, RXRA, NKX2-1, PROX1, MCRS1, GABPA, STAT3, XRCC5, ZNF614, APC, MIER3, HNRNPH1, NR2F6, DNMT3B, RCOR1, VDR, NR3C1, CEBPB, ARNTL, CREB1, CCAR2, EZH2, ZNF652, GABPB1, ZHX2, SPI1, TFE3, MIXL1, PCBP1, HDAC2, GATA2, ZNF644, MXD3, FLI1, SREBF1, DRAP1, ZGPAT, MXI1, NFIL3, MRTFB, MYF5, ETV5, PTBP1, RUNX1, THAP11, BCL6, CBX1, CEBPA, LDB1, SMC1A, SOX13, SIN3A, ZFX, SMAD3, PCBP2, TET2, ERG3, SP5, SMARCC1, RARA, NFYC, ZNF35, RUNX2, GATA4, ARNT, PBX4, DAXX, ZNF48, ATF2, SMAD4, PBX3, FOS, CDK8, HMGXB4, TGIF2, CHD1, MED1, TEAD3, ZEB1, CEBPD, MYB, ZMYM3, U2AF1, VEZF1, ZNF3, KLF9, SETDB1, MBD1, MAFK, BCL11A, SP1, TFAP2A, HNF4A, NIPBL, IKZF5, REST, ZBTB7A, ARID1A, RBM25, ARID2, POU2F3, ATF7, ASH2L, PHIP, TCF3, FOXP1, AATF, SMC3, STAG1, ETV4, TRP47, CBFA2T2, PPARG, FOXA2, CREM, SS18, MIER2, ZNF600, GTF2B, WT1, MAFF, ESR2, ZBTB33, TCF7, ZNF580, FOXO3, KDM1A, YY1, RELA, NEUROD1, JUNB, BRG1, BRCA1, SP140, MCM3, HIF1A, ZIC2, OTX2, GATA3, BATF, MAX, GATA1, ZNF143, PLAG1, CEBPG, NR2F2, NEUROG2, NR2F1, TCF7L2, KDM5B, TP53, PKNOX1, ZBTB6, ZNF334, NFKB1, MYOD1, ELF3, PHF5A, KAT8, BRD2, ARID4B, NFKBIZ, BHLHE40, TAF1, AR, PAX3-FOXO1, YAP1, ZBTB42, EGR1, MYNN, ZBTB26, HSF1, JUND, BRD4, RNF2, MAZ, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): PDE9A
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 31
- Related genes and loops