- Basic information
- CohesinDB ID: CDBP00420225
- Locus: chr21-42043276-42045446
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Data sourse: GSE206145-GSE177045, GSE67783, GSE72082, GSE86191, GSE111913, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, ENCSR703TNG, GSE25021
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Cell type: MCF-7, RPE, Fibroblast, HCT-116, RT-112, K-562, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 6% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.922
- Subunit: SA1,Rad21,SMC1,SA2,Mau2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
94% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 65%,
"14_ReprPCWk": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: TRIM25, PGR, FOXA1, ATF3, SMARCE1, TP63, ELF1, RBM39, SNAI2, ZNF217, ESR1, OCA2, JUN, CTCF, BAF155, MNT, DPF2, SOX4, TFAP2C, NANOG, CHD8, MYCN, ZNF263, CTBP1, ZBTB17, DUX4, ZBTB48, DDX5, ERG, ASCL1, MYC, RAD21, GRHL3, PROX1, NKX3-1, PRDM14, DNMT3B, NR3C1, SRSF3, EZH2, GRHL2, HDAC2, GATA2, NCOA2, RUNX1, CBX1, SMC1A, ZFX, SMAD3, TET2, ERG3, CBX8, SMARCC1, CREBBP, ZXDC, NOTCH1, ZNF384, ARNT, TFDP1, PRDM9, SMARCB1, MED1, TERF1, MYB, PIAS1, ARID2, REST, HNRNPLL, CTBP2, STAG1, TRP47, ZSCAN16, WT1, RELA, MCM3, SP140, TCF4, HIF1A, GATA3, TAL1, MAX, NRIP1, ZNF143, CBX2, KLF4, NCOA3, NR2F2, NR2F1, KDM5B, TP53, ZNF334, NFKB1, AR, EGLN2, HSF1, BRD4, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): PDE9A
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 16
- Related genes and loops