- Basic information
- CohesinDB ID: CDBP00420232
- Locus: chr21-42072432-42077357
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, ENCSR000BLY, GSE105028, GSE111537, GSE25021, GSE108869, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE206145-NatGen2015, GSE120943, GSE94872, GSE98367, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR000BMY, GSE97394, ENCSR000BTQ, GSE129526, GSE111913, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE50893, ENCSR000ECS
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Cell type: HuCC-T1, H9-hESC, RPE, Fibroblast, HeLa-S3, GM2255, K-562, GM18486, H1-hESC, GM18951, Monocytes, GM12878, GM12891, SK-N-SH, RT-112, Macrophage, HUES64, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, HUVEC, OCI-AML-3, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 10% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.733
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
94% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"14_ReprPCWk": 32%,
"15_Quies": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, XBP1, FOXA1, SUZ12, HDGF, ATF3, RUNX3, PAX5, TP63, ZSCAN4, KLF5, TEAD1, TRIM28, BCLAF1, ESR1, JUN, CTCF, TCF12, DPF2, E2F6, IRF4, TFAP2C, EED, POU2F2, MYCN, ZNF263, RUNX1T1, MTA2, ZBTB48, NBN, USP7, MYC, RFX1, RAD21, GRHL3, GABPA, ZNF398, IKZF1, DNMT3B, SPI1, GATA2, SMARCA5, RUNX1, ZFX, TET2, TRIM22, ZBTB2, NRF1, ZBTB10, PBX3, SMARCB1, MYB, SCRT2, SP1, BCL11A, ZBTB7A, ATF7, TCF3, AATF, SMC3, MLLT1, STAG1, NFATC3, TRP47, CBFA2T2, CREM, EBF1, WT1, ZNF662, BCL3, RELA, JUNB, MCM3, SP140, BATF, TAL1, ZNF143, PLAG1, NR2F1, ZNF334, TBX21, BHLHE40, AR, RXR, EGR1, HSF1, IKZF2, SCRT1, BRD4, MAZ, ZNF316
- Target gene symbol (double-evidenced CRMs): ZBTB21,SLC37A1,C2CD2,RIPK4,BACE2,PRDM15,PKNOX1,FAM3B,UMODL1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 352
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000182240,
ENSG00000183844,
ENSG00000183421,
ENSG00000141956,
ENSG00000157617,
ENSG00000173276,
ENSG00000177398,
ENSG00000160190,
ENSG00000160199,
- Related loop:
chr21:41275000-41300000~~chr21:42075000-42100000,
chr21:41600000-41625000~~chr21:42050000-42075000,
chr21:41600000-41625000~~chr21:42075000-42100000,
chr21:41725000-41750000~~chr21:42075000-42100000,
chr21:41750000-41775000~~chr21:42075000-42100000,
chr21:41850000-41875000~~chr21:42050000-42075000,
chr21:41850000-41875000~~chr21:42075000-42100000,
chr21:41925000-41950000~~chr21:42075000-42100000,
chr21:41975000-42000000~~chr21:42075000-42100000,
chr21:42050000-42075000~~chr21:42525000-42550000,
chr21:42050000-42075000~~chr21:42975000-43000000,
chr21:42050000-42075000~~chr21:43350000-43375000,
chr21:42050000-42075000~~chr21:44250000-44275000,
chr21:42062098-42064822~~chr21:42076418-42078634,
chr21:42075108-42076806~~chr21:42106936-42108928,