Deatailed information for cohesin site CDBP00420233

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  • Basic information
  • CohesinDB ID: CDBP00420233
  • Locus: chr21-42077774-42087507
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE103477, GSE131606, GSE25021, GSE165895, GSE115602, ENCSR000BTU, ENCSR917QNE, ENCSR000DZP, ENCSR000EAC, GSE67783, GSE86191, GSE93080, GSE76893, GSE206145-NatGen2015, GSE120943, ENCSR703TNG, GSE98367, ENCSR879KXD, GSE206145, GSE62063, ENCSR000BMY, ENCSR000BTQ, GSE38395, ENCSR000HPG, GSE111913, GSE155324, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE50893, ENCSR000ECS, GSE38411
  • Cell type: MDM, GM10847, GM2610, HSPC, Liver, HuCC-T1, RPE, GM2630, Fibroblast, Ishikawa, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, HFFc6, DKO, H1-hESC, SNYDER, Monocytes, GM18505, Lymphoblast, GM12878, GM2588, RT-112, GM19099, Macrophage, MCF-7, GM12892, Ramos, HCT-116, GM18951
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 19% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.622
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 94% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "7_Enh": 26%, "15_Quies": 25%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, PGR, ZNF675, ZNF660, SOX2, XBP1, PATZ1, FOXA1, SUZ12, ZFHX2, HDGF, BMI1, ATF3, NFIC, INSM2, RUNX3, ZBTB44, PAX5, TP63, ZNF736, JMJD1C, ZNF629, ELF1, BCLAF1, SNAI2, ESR1, OCA2, MLL, USF2, ZFP91, CTCF, TCF12, JUN, EP300, E4F1, BAF155, MNT, DPF2, E2F6, IRF4, TRIM24, RAD51, E2F1, ZNF677, ZNF528, ZNF280A, KMT2B, GTF2F1, YBX1, GLIS1, JARID2, POU2F2, ZSCAN5D, MYCN, ZNF263, TOP2A, ID3, POU5F1, MTA2, ZBTB17, ZBTB48, ZSCAN21, STAT1, ZNF317, ZSCAN5A, SRF, ZNF563, DUX4, NBN, ERG2, ERG, ZBTB21, MYC, EOMES, RFX1, SMARCA4, RAD21, TSHZ1, GRHL3, FOXK2, GABPA, STAT3, NKX3-1, PRDM14, IKZF1, NFE2, DNMT3B, RCOR1, ZNF639, VDR, ZNF667, NR3C1, CEBPB, ZNF750, KMT2A, CREB1, EPAS1, EZH2, FEZF1, GRHL2, ZHX2, SPI1, ZNF257, IRF1, INTS13, GATA2, GATAD2B, FLI1, HCFC1, MXI1, SMARCA5, RELB, HCFC1R1, MRTFB, NCOA2, ZNF554, RUNX1, HEXIM1, SMC1A, BCL6, CEBPA, ZFX, ZNF534, ZNF770, ERG3, TET2, CBX8, TRIM22, CREBBP, TAF15, RUNX2, OSR2, ZNF184, SP3, ARNT, BACH1, PBX4, ATF2, ZEB2, PBX3, NR2C1, FOS, CDK8, CHD1, MED1, ZEB1, ZNF264, MYB, SCRT2, PIAS1, ZNF3, L3MBTL2, SREBF2, STAT5A, USF1, SP1, BCL11A, MAFK, NIPBL, ZBTB7A, ATF7, POU2F3, TCF3, BCOR, GLIS2, AATF, STAG1, MLLT1, NFATC3, SKI, ZNF394, PAX7, TRP47, MEF2B, PPARG, ZNF207, EBF1, CHD2, CREM, NFATC1, ZNF600, ZNF692, ZSCAN16, WT1, ZNF574, MEF2C, CDK9, HOXB13, BCL3, YY1, RELA, TARDBP, JUNB, BRG1, SP140, TCF4, SKIL, HIF1A, ZIC2, MAX, ZNF143, PLAG1, CBX2, CEBPG, ZFP69B, SP7, GFI1B, NR2F1, KDM5B, ZNF687, PKNOX1, TP53, ZNF334, NFKB1, EGR2, TBX21, BHLHE40, AR, ZBTB40, RXR, ZNF366, EGR1, RB1, ZBTB42, HSF1, NCOR1, IKZF2, BRD4, SCRT1, RNF2, ILF3, MAZ, ZSCAN23, ZNF24, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): PRDM15,BACE2,RIPK4,ZBTB21,C2CD2,UMODL1,FAM3B
  • Function elements
  • Human SNPs: Obesity-related_traits
  • Number of somatic mutations (coding): 612
  • Number of somatic mutations (non-coding): 93
  • Related genes and loops
  • Related gene: ENSG00000182240, ENSG00000183844, ENSG00000183421, ENSG00000141956, ENSG00000157617, ENSG00000173276, ENSG00000177398,
  • Related loop: chr21:41275000-41300000~~chr21:42075000-42100000, chr21:41600000-41625000~~chr21:42050000-42075000, chr21:41600000-41625000~~chr21:42075000-42100000, chr21:41725000-41750000~~chr21:42075000-42100000, chr21:41750000-41775000~~chr21:42075000-42100000, chr21:41850000-41875000~~chr21:42050000-42075000, chr21:41850000-41875000~~chr21:42075000-42100000, chr21:41925000-41950000~~chr21:42075000-42100000, chr21:41975000-42000000~~chr21:42075000-42100000, chr21:42050000-42075000~~chr21:42525000-42550000, chr21:42050000-42075000~~chr21:42975000-43000000, chr21:42050000-42075000~~chr21:43350000-43375000, chr21:42050000-42075000~~chr21:44250000-44275000, chr21:42062098-42064822~~chr21:42076418-42078634, chr21:42075108-42076806~~chr21:42106936-42108928,
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