- Basic information
- CohesinDB ID: CDBP00420235
- Locus: chr21-42089069-42090481
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Data sourse: ENCSR230ZWH, GSE67783, GSE72082, GSE86191, GSE206145-NatGen2015, ENCSR153HNT, ENCSR917QNE
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Cell type: Fibroblast, HCT-116, Hep-G2, K-562, Liver, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: SA1,Rad21
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
94% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 32%,
"14_ReprPCWk": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, XBP1, SUZ12, HDGF, ATF3, RUNX3, CBFB, CDX2, MAF, ZNF506, ELF1, ESR1, USF2, CTCF, TCF12, EP300, LMO1, E2F4, RAD51, RBPJ, POU2F2, ZNF263, MYCN, CDK7, ZBTB48, ZSCAN5A, DUX4, SRF, HNF4G, ERG, OGG1, ZNF341, MYC, SMARCA4, RAD21, GRHL3, RXRA, GABPA, STAT3, XRCC5, APC, PRDM14, IKZF1, DNMT3B, TERF2, NR2F6, CEBPB, KMT2A, CREB1, SPI1, ZNF644, RUNX1, SMC1A, BCL6, CBX1, CEBPA, ZFX, TET2, RUNX2, OSR2, ARNT, SOX11, PBX3, FOS, CHD1, MED1, TEAD3, KDM6B, MYB, SCRT2, ZNF3, SETDB1, USF1, SP1, TFAP2A, HNF4A, TCF3, FOXP1, AATF, SMC3, STAG1, TRP47, PPARG, FOXA2, ZNF207, WT1, BCL3, YY1, RELA, TARDBP, BRG1, SP140, ZIC2, TCF4, GATA3, TAL1, MAX, ZNF143, GATA1, PLAG1, NR2F1, ZNF334, NFKB1, T, ELF3, TBX21, BHLHE40, AR, RXR, HEXIM1, HSF1, RNF2, IKZF2, BRD4, SCRT1, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): UMODL1,C2CD2,PRDM15,RIPK4,FAM3B,ZBTB21,BACE2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 244
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000182240,
ENSG00000183844,
ENSG00000183421,
ENSG00000141956,
ENSG00000157617,
ENSG00000173276,
ENSG00000177398,
- Related loop:
chr21:41275000-41300000~~chr21:42075000-42100000,
chr21:41600000-41625000~~chr21:42075000-42100000,
chr21:41725000-41750000~~chr21:42075000-42100000,
chr21:41750000-41775000~~chr21:42075000-42100000,
chr21:41815737-41818316~~chr21:42094326-42095544,
chr21:41850000-41875000~~chr21:42075000-42100000,
chr21:41925000-41950000~~chr21:42075000-42100000,
chr21:41975000-42000000~~chr21:42075000-42100000,