- Basic information
- CohesinDB ID: CDBP00420236
- Locus: chr21-42091730-42092368
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Data sourse: GSE206145, GSE206145-NatGen2015, GSE67783, GSE86191
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Cell type: RPE, Fibroblast, HCT-116, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: SA1,Rad21,SA2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
94% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 28%,
"14_ReprPCWk": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, PGR, XBP1, FOXA1, SUZ12, SFMBT1, ZNF90, ATF3, NFIC, HNRNPUL1, ZBTB5, CHD7, THAP1, ZNF362, CTCFL, ZNF189, PAX5, KLF5, TEAD1, TRIM28, ZNF121, RBM39, NFE2L2, LMO2, ESR1, CTCF, TCF12, JUN, EP300, RYBP, E2F6, RFX5, E2F4, DEK, E2F1, TEAD4, GTF2F1, PDX1, TFAP2C, POU2F2, BRD1, ZSCAN5D, MYCN, POU5F1, BRD3, ID3, DUX4, ZBTB48, ZSCAN5A, SRF, DDX5, TBP, HOXC5, CHD4, ZNF341, ETS1, MYC, SMARCA4, KDM4A, RFX1, RAD21, GRHL3, RXRA, STAT3, XRCC5, UBN1, NKX3-1, PRDM14, RCOR1, HNRNPH1, NR3C1, CEBPB, ESRRA, KMT2A, CREB1, EZH2, BMPR1A, GRHL2, ZHX2, ZNF664, HDAC2, FLI1, MXI1, HCFC1R1, RUNX1, BCL6, SMC1A, CBX1, NKX2-2, CRY1, SIN3A, ZFX, AFF4, SMAD3, TET2, CBX8, SMARCC1, ZNF384, RUNX2, CDK6, PBX4, NRF1, ELK1, FOXM1, PBX3, MAFB, FOS, SMARCB1, MED1, CEBPD, ZMYM3, SMAD1, PIAS1, SETDB1, ZNF22, USF1, SP1, MAFK, BCL11A, ARID1A, ZBTB7A, RBM25, POU2F3, ASH2L, BCOR, FOXP1, AATF, SMC3, ELL2, STAG1, TRP47, CBFA2T2, FOXA2, CBX3, RBBP5, CHD2, EBF1, WT1, MAFF, KDM1A, YY1, RELA, TARDBP, JUNB, BRG1, MCM3, SP140, ZIC2, HIF1A, GATA3, TAL1, MAX, NRIP1, ZNF143, GATA1, CBX2, NR2F1, NEUROG2, KDM5B, TP53, ZNF334, NFKB1, BRD2, ELF3, BHLHE40, AR, ZNF280D, HSF1, BRD4, JUND, CLOCK, MAZ, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): UMODL1,ZBTB21,FAM3B,C2CD2,PRDM15,RIPK4,BACE2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 16
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000182240,
ENSG00000183844,
ENSG00000183421,
ENSG00000141956,
ENSG00000157617,
ENSG00000173276,
ENSG00000177398,
- Related loop:
chr21:41275000-41300000~~chr21:42075000-42100000,
chr21:41600000-41625000~~chr21:42075000-42100000,
chr21:41725000-41750000~~chr21:42075000-42100000,
chr21:41750000-41775000~~chr21:42075000-42100000,
chr21:41815737-41818316~~chr21:42094326-42095544,
chr21:41850000-41875000~~chr21:42075000-42100000,
chr21:41925000-41950000~~chr21:42075000-42100000,
chr21:41975000-42000000~~chr21:42075000-42100000,