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Basic information

CohesinDB ID: CDBP00420241

Locus: chr21-42103416-42126825

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE130140, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: GM2610, CUTLL1, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, Ramos, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, CNCCs-H9ESC, HeLa-Tet-On, THP-1, HUES64, HeLa, BGO3, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, Transformed-RPE1, HuCC-T1, RPE, HMEC, Ishikawa, Kelly, K-562, Leukemia-SEM, HUES9, GM19099, T-47D, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 86% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.089

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 94% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 23%, "14_ReprPCWk": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, TRIM25, SMARCA2, HMG20A, ZNF660, SOX2, NME2, MEIS2, XBP1, HNF1A, PATZ1, FOXA1, SUZ12, RXRB, PBX2, MLL4, UBTF, ZFHX2, HNRNPK, TFAP4, MTA2, ATF3, NFIC, ZFP64, THAP1, ZBTB44, CHD7, IKZF3, RUNX3, CBFB, ZNF189, SMARCE1, MECOM, TP63, PAX5, MITF, ZNF736, BACH2, CDX2, ZNF629, JMJD1C, KLF5, TEAD1, TRIM28, ELF1, KLF6, ZNF26, NFE2L2, ETV1, LMO2, ESR1, HNF1B, TP73, SNAI2, OCA2, JUN, CTCF, TCF12, BAF155, EP300, TAF3, MNT, LMO1, SOX5, GATA6, DPF2, TRIM24, RFX5, IRF4, SOX6, ZNF674, RAD51, PRKDC, E2F1, ZNF528, ZNF280A, TEAD4, KMT2B, GTF2F1, PDX1, TFAP2C, RBPJ, EED, CHD8, BRD1, POU5F1, MYCN, BRD3, ZNF263, ZNF778, CDK7, ZNF317, ZBTB17, ZBTB48, ZSCAN5A, STAT1, ZSCAN21, DUX4, SRF, ZNF134, SAP130, DDX5, ARID3A, TBP, ERG, HOXC5, ZBTB21, ASCL1, ZBTB8A, ETS1, MYC, SMARCC2, SMARCA4, ZNF180, TSHZ1, RAD21, HOMEZ, GRHL3, PROX1, NKX2-1, GABPA, STAT3, ZNF614, UBN1, NKX3-1, XRCC5, GFI1, NFE2, RCOR1, ZNF639, NR2F6, ARNTL, IKZF1, NR3C1, CEBPB, ZNF750, KMT2A, CREB1, EZH2, KLF8, GRHL2, FEZF1, MRTFA, ZHX2, SPI1, MIXL1, EHF, IRF1, KLF17, HDAC2, GATA2, ZNF121, FLI1, ZNF777, RELB, HCFC1R1, MRTFB, ZNF554, ETV5, RUNX1, AHRR, BCL6, SMC1A, CBX1, LDB1, NKX2-2, CEBPA, ZNF335, ZFX, AFF4, SOX13, SIN3A, SMAD3, ZNF770, CBX8, TET2, ERG3, RBM39, TRIM22, SMARCC1, PRDM10, ZNF549, CREBBP, RARA, ZNF35, ZNF384, RUNX2, GATA4, OSR2, ZNF184, NRF1, PBX4, ARNT, DAXX, ZEB2, ZNF518A, PBX3, MAFB, ZNF10, FOS, CDK8, CHD1, SMARCB1, MED1, TEAD3, ZEB1, ZNF558, MYB, PIAS1, ZNF331, KLF9, C11orf30, EVI1, SREBF2, MAFK, BCL11A, NIPBL, SP1, TFAP2A, HNF4A, ARID2, IKZF5, ZBTB7A, ARID1A, REST, ATF7, ZHX1, ASH2L, HNRNPLL, PHIP, TCF3, PRDM6, AATF, SMC3, ELL2, NCOR2, STAG1, MLLT1, ZNF394, NFATC3, TRP47, MEF2B, PPARG, FOXA2, CBX3, CREM, MEIS1, SS18, CHD2, ZNF600, ZNF692, ZSCAN16, WT1, MAFF, ZNF30, FOXF1, ZNF574, CDK9, HOXB13, KDM1A, YY1, RELA, TARDBP, NEUROD1, JUNB, SP140, HIF1A, SKIL, OTX2, GATA3, TAL1, MAX, NRIP1, GATA1, MTA1, CBX2, KLF4, ZFP69B, SP7, NCOA3, GFI1B, BAP1, NR2F2, EBF1, TCF7L2, NR2F1, KDM5B, TP53, PKNOX1, MED, ZNF334, NFKB1, MYOD1, BRD2, ELF3, KAT8, TBX21, BHLHE40, AR, TAF1, RXR, ZNF324, EGLN2, ZNF366, ZBTB42, RB1, ZBTB26, RNF2, NCOR1, BRD4, JUND, HSF1, IKZF2, MAZ, ZSCAN23, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): HSF2BP,WDR4,UMODL1,RRP1B,ZBTB21,TMPRSS3,FAM3B,BACE2,C2CD2,MX1,ABCG1,TMPRSS2,RSPH1,PDE9A,RIPK4,UBASH3A,PRDM15,SLC37A1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 2668

Number of somatic mutations (non-coding): 474

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000157601, ENSG00000184012, ENSG00000183421, ENSG00000141956, ENSG00000157617, ENSG00000173276, ENSG00000177398, ENSG00000160179, ENSG00000160183, ENSG00000160185, ENSG00000160188, ENSG00000160190, ENSG00000160191, ENSG00000160193, ENSG00000160207, ENSG00000160208,

eachgene

Deatailed information for cohesin site CDBP00420241