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Basic information

CohesinDB ID: CDBP00420242

Locus: chr21-42127155-42127810

Data sourse: GSE131606, GSE111913, GSE86191

Cell type: RT-112, HCT-116, DKO

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: Rad21,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 94% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 39%, "14_ReprPCWk": 36%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NME2, FOXA1, HLF, RXRB, ZBTB7B, HDGF, MEN1, THAP1, PAX5, ZNF320, TEAD1, LMO2, OCA2, PITX3, ARID5B, E4F1, SOX5, PAX8, DEK, ZNF528, GATAD2A, NANOG, ZNF263, POU5F1, TOP2A, CTBP1, DUX4, STAT1, SAP130, ERG, EZH1, SMARCA4, FOXK2, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, MXI1, RELB, RUNX1, CEBPA, NKX2-2, HDAC1, CRY1, ZNF654, TET2, SP5, MCM2, TRIM22, ZNF549, PRDM10, SMARCC1, ZBTB2, ZXDC, ATF2, SATB1, FOXM1, SMARCB1, PIAS1, SMAD1, NR1H2, EVI1, STAT5A, IKZF5, ELL2, NFATC3, MEF2B, CBX3, ZNF207, CREM, CHD2, SS18, NFATC1, ZSCAN16, WT1, MEF2C, NEUROD1, JUNB, MCM3, TCF4, ZFP36, ZNF311, BATF, MAF1, KLF4, BCL11B, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, ZBTB26, NCOR1, HSF1, SCRT1, ILF3, FOSL1, ZNF660, ZNF101, PBX2, ATF3, ZC3H8, ZFP64, RUNX3, WDHD1, CBFB, TP63, ZSCAN4, MITF, ZNF467, JMJD1C, ELF1, RBM39, SNAI2, CTCF, JUN, LMO1, MNT, DPF2, IRF4, ZNF776, PDX1, RBPJ, TFAP2C, MTA2, ZBTB17, ZSCAN21, ZBTB48, UTX, SRF, DDX5, NBN, PBX1, ZNF2, HOMEZ, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, KMT2A, GRHL2, EBF3, SSRP1, SMARCA5, NFIL3, THAP11, LDB1, SOX13, AFF4, ZNF747, ARNT, BACH1, NFIB, DAXX, ZNF48, ZEB2, NFYA, PBX3, MAFB, NCAPH2, HMGXB4, ICE2, TEAD3, U2AF1, KLF9, USF1, BCL11A, SP1, TFAP2A, ATF7, ASH2L, CTBP2, GLIS2, PRDM6, SMC3, MLLT1, STAG1, STAG2, TRP47, AGO1, EBF1, MAFF, ZNF580, BCL3, ZKSCAN1, KDM1A, BRG1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, AGO2, CBX2, TP53, ZNF334, NFKB1, BRD2, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, PGR, SOX2, TFAP4, BMI1, CHD7, ZNF444, MXD4, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, TP73, KLF1, SOX4, E2F6, PRKDC, GLIS1, POU2F2, ZSCAN5A, ERG2, TBP, HOXC5, OGG1, MYC, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, EZH2, ZNF436, SPI1, PCBP1, HDAC2, GATAD2B, NCOA2, ETV5, SALL2, AHRR, BCL6, SIN3A, ERG3, RARA, ZNF384, ZNF35, CREBBP, TAF15, SMAD4, CDK8, ZEB1, ZMYM3, SREBF2, MAFK, HNF4A, NR4A1, REST, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, PPARG, GTF2B, ZNF30, ZNF574, TCF7, RELA, TARDBP, SKIL, MAX, ZNF592, GFI1B, TCF7L2, NR2F1, KDM5B, NEUROG2, PKNOX1, MYOD1, AR, ZBTB16, ZNF324, HEXIM1, AHR, FOSL2, MBD3, HMG20A, MEIS2, SUZ12, ZFHX2, LYL1, NFIC, CTCFL, PRDM1, MECOM, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, HNF1B, USF2, TCF12, BAF155, EP300, GATA6, GLI4, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, CDK7, ID3, GATAD1, ARID3A, ZNF300, ASCL1, ZNF341, MCM5, RAD21, GRHL3, PROX1, XRCC5, ZNF614, NFE2, ARNTL, ZNF750, JMJD6, TRPS1, HES1, TFE3, ZGPAT, MRTFB, MYF5, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, ZNF534, SMAD3, CBX8, NOTCH1, RUNX2, GATA4, GR, PBX4, CHD1, SUPT5H, FOS, MED1, MYB, SCRT2, ZNF3, L3MBTL2, SETDB1, NIPBL, ZBTB7A, POU2F3, PHIP, TCF3, SKI, FOXA2, RBBP5, ZNF600, MIER2, ZBTB33, CDK9, HOXB13, YY1, SP140, HIF1A, OTX2, BHLHE22, ZNF519, ZNF449, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, NFKBIZ, BHLHE40, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): BACE2,ABCG1,PDE9A,RSPH1,SLC37A1,UMODL1,WDR4,TMPRSS2,UBASH3A,HSF2BP,RRP1B,MX1,TMPRSS3,FAM3B

Function elements

Human SNPs: .

Number of somatic mutations (coding): 356

Number of somatic mutations (non-coding): 89

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000157601, ENSG00000184012, ENSG00000177398, ENSG00000160179, ENSG00000160183, ENSG00000160185, ENSG00000160188, ENSG00000160190, ENSG00000160191, ENSG00000160193, ENSG00000160207, ENSG00000160208,

eachgene

Deatailed information for cohesin site CDBP00420242