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Basic information

CohesinDB ID: CDBP00420243

Locus: chr21-42128488-42129619

Data sourse: GSE86191, GSE67783, ENCSR153HNT, GSE83726

Cell type: K-562, RH4, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 94% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 42%, "14_ReprPCWk": 35%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, ZBTB24, ZSCAN5D, ZFX, NME2, ZNF692, ZBTB48, WT1, FOXA1, SUZ12, KDM1A, ZBTB2, NFYC, NOTCH1, ZNF384, AHR, MYC, GATA4, SP140, NKX2-1, GABPA, DPF1, STAT3, MAX, ZSCAN4, FOS, SUPT5H, RCOR1, GATA1, MITF, CBX2, PLAG1, NR3C1, CEBPB, TEAD1, STAT5B, MYB, TRIM28, ZMYM3, LMO2, TP53, ESR1, USF2, CTCF, TCF12, USF1, SPI1, BCL11A, AR, IRF4, RBM25, RAD51, BRD4, TCF3, BCOR, MAZ, NFYB, ZNF92, STAG1, TFAP2C

Target gene symbol (double-evidenced CRMs): RRP1B,FAM3B,ABCG1,TMPRSS2,RSPH1,UBASH3A,TMPRSS3,MX1,WDR4,BACE2,PDE9A,UMODL1,SLC37A1,HSF2BP

Function elements

Human SNPs: .

Number of somatic mutations (coding): 28

Number of somatic mutations (non-coding): 7

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000157601, ENSG00000184012, ENSG00000177398, ENSG00000160179, ENSG00000160183, ENSG00000160185, ENSG00000160188, ENSG00000160190, ENSG00000160191, ENSG00000160193, ENSG00000160207, ENSG00000160208,

eachgene

Deatailed information for cohesin site CDBP00420243