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Basic information

CohesinDB ID: CDBP00420248

Locus: chr21-42136966-42138370

Data sourse: GSE206145-GSE177045, GSE67783, GSE86191, GSE206145, GSE206145-NatGen2015

Cell type: MCF-7, RPE, Fibroblast, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: Mau2,SA1,Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 94% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 54%, "14_ReprPCWk": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, TRP47, CBFA2T2, BRD1, SIRT6, MYCN, ZFX, ZBTB48, WT1, FOXA1, TET2, ZBTB33, SUZ12, ERG3, ERG2, ZFHX2, YY1, RELA, CREBBP, TARDBP, ATF3, MYC, SP140, HIF1A, KLF14, TAL1, TP63, CHD1, SUPT5H, CDK8, DNMT3B, CBX2, PLAG1, NR3C1, SRSF3, TRIM28, MYB, NR2F1, LMO2, ESR1, GRHL2, EGR2, CTCF, AR, HSF1, BRD4, MAZ, STAG1, AHR, EED

Target gene symbol (double-evidenced CRMs): TMPRSS3,MX1,SLC37A1,RSPH1,UBASH3A,ABCG1,PDE9A,TMPRSS2,HSF2BP,UMODL1,FAM3B,WDR4,BACE2,RRP1B

Function elements

Human SNPs: .

Number of somatic mutations (coding): 296

Number of somatic mutations (non-coding): 11

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000157601, ENSG00000184012, ENSG00000177398, ENSG00000160179, ENSG00000160183, ENSG00000160185, ENSG00000160188, ENSG00000160190, ENSG00000160191, ENSG00000160193, ENSG00000160207, ENSG00000160208,

eachgene

Deatailed information for cohesin site CDBP00420248