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Basic information

CohesinDB ID: CDBP00420258

Locus: chr21-42171081-42172120

Data sourse: GSE131606, GSE104888, GSE67783, GSE86191, ENCSR000BSB, GSE138405, GSE129526, GSE111913, GSE206145, GSE101921, GSE62063, GSE85526, ENCSR153HNT, ENCSR000EDE, GSE68388, ENCSR703TNG, GSE126990, GSE108869, ENCSR000ECS

Cell type: MCF-7, Hela-Kyoto, HCT-116, MCF-10A, HEKn, HEK293T, Ramos, HeLa-S3, RT-112, K-562, HSPC, HuCC-T1, DKO

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 5% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.856

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 94% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 51%, "7_Enh": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, FOSL1, PGR, SOX2, XBP1, FOXA1, ZNF28, ZFHX2, TFAP4, ATF3, NFIC, ZC3H8, PRDM1, PAX5, TP63, CDX2, MAF, KLF5, TRIM28, KLF6, SNAI2, ESR1, CTCF, JUN, BAF155, KLF1, EP300, GATA6, RFX5, DEK, E2F1, TEAD4, GTF2F1, TFAP2C, ZSCAN5D, POU5F1, MYCN, TOP2A, STAT1, NBN, TBP, ERG, SMARCC2, MYC, SMARCA4, RAD21, PROX1, NKX2-1, GABPA, STAT3, APC, XRCC5, RCOR1, NR3C1, CEBPB, ZNF750, CREB1, GRHL2, SPI1, EHF, IRF1, ZNF257, GATA2, MXI1, ZNF490, RELB, ZNF554, RUNX1, SMC1A, ZBTB24, BCL6, AFF4, ZFX, SMAD3, ERG3, SMARCC1, CREBBP, ZNF384, CDK6, GATA4, ZNF184, ARNT, PBX4, NRF1, NFIB, FOXM1, MAFB, FOS, CDK8, SMARCB1, MED1, ZEB1, SMAD1, NR1H2, NCOA1, SETDB1, BCL11A, NIPBL, SP1, HNF4A, ZHX1, PHIP, FOXP1, SMC3, ELL2, STAG2, STAG1, PAX7, CBFA2T2, FOXA2, CHD2, PAF1, SS18, ZNF692, ZNF662, HOXB13, KDM1A, YY1, RELA, JUNB, BRG1, HIF1A, GATA3, MAX, GATA1, KLF4, ZNF544, TCF7L2, TP53, ELF3, BRD2, ARRB1, AR, PAX3-FOXO1, ZNF579, HSF1, BRD4, JUND, MAZ

Target gene symbol (double-evidenced CRMs): RSPH1,WDR4,HSF2BP,ABCG1,SLC37A1,UBASH3A,TMPRSS3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 6

Related genes and loops

Related gene: ENSG00000160179, ENSG00000160183, ENSG00000160185, ENSG00000160188, ENSG00000160190, ENSG00000160193, ENSG00000160207,

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Deatailed information for cohesin site CDBP00420258