- Basic information
- CohesinDB ID: CDBP00420269
- Locus: chr21-42198731-42200403
-
Data sourse: ENCSR230ZWH, ENCSR000BSB, ENCSR501LQA, ENCSR150EFU, ENCSR000ECS, ENCSR330ELC, GSE108869, ENCSR917QNE, ENCSR000DZP, GSE67783, GSE86191, GSE138405, GSE101921, ENCSR806UKK, GSE206145-NatGen2015, GSE120943, ENCSR895JMI, GSE98367, ENCSR193NSH, ENCSR879KXD, ENCSR981FDC, ENCSR247LSH, GSE62063, ENCSR620NWG, ENCSR767DFK, ENCSR217ELF, ENCSR853VWZ, GSE111913, ENCSR335RKQ, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE50893, GSE126755, ENCSR748MVX
-
Cell type: Macrophage, HMEC, Fibroblast, HCT-116, Hela-Kyoto, Monocytes, GM12878, A-549, HeLa-S3, HuCC-T1, RT-112, K-562, Liver, Neutrophil, HSPC, GM18486, Ramos
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 11% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.811
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
94% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"7_Enh": 39%,
"15_Quies": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, HMG20A, ZNF660, XBP1, PATZ1, FOXA1, HLF, RXRB, MLL4, HDGF, LYL1, ATF3, BMI1, RUNX3, ATF4, ZNF189, SMARCE1, MECOM, ZSCAN4, TP63, BACH2, CDX2, ZNF629, JMJD1C, KLF5, ELF1, TRIM28, MAF, KLF6, ETV1, TEAD1, NFE2L2, SAP30, ESR1, MLL, ZNF217, PITX3, HDAC8, LMO2, CTCF, TCF12, JUN, EP300, E4F1, BAF155, KLF1, SOX5, DPF2, IRF4, TRIM24, RFX5, SOX6, DEK, ZNF528, ZNF350, TEAD4, KMT2B, ZNF175, FOXA3, GATAD2A, PDX1, RBPJ, EED, GTF2F1, NANOG, POU2F2, CHD8, BRD3, MYCN, RUNX1T1, CTBP1, ZSCAN21, ZBTB17, ZBTB48, MTA2, ELK4, STAT1, ZNF317, SAP130, NBN, ARID3A, TBP, ERG, ZBTB21, HOXC5, ETS1, MYC, SMARCA4, ARID1B, RAD21, GRHL3, RXRA, PROX1, GABPA, STAT3, ZNF614, UBN1, NKX3-1, ZNF398, IKZF1, RCOR1, LEF1, NR2F6, MIER3, VDR, NFE2, NR3C1, CEBPB, ESRRA, ZNF750, KMT2A, CREB1, EZH2, TBL1XR1, MRTFA, GABPB1, SPI1, ZNF664, EHF, MIXL1, IRF1, INTS13, GATA2, FLI1, NR2C2, SMARCA5, MRTFB, NFIL3, EP400, ATF1, ETV5, RUNX1, THAP11, SMC1A, BCL6, HDAC1, NKX2-2, CEBPA, AFF4, ZNF335, SOX13, ZFX, SMAD3, SMARCC1, PRDM10, RARA, RUNX2, ZNF184, PBX4, NRF1, ELK1, ARNT, ATF2, PRDM9, ZNF518A, ZEB2, SMAD4, MAFB, FOS, CDK8, SMARCB1, SNRNP70, MED1, ZEB1, TERF1, ZNF558, CEBPD, SCRT2, PIAS1, MYB, SMAD1, PML, NR1H2, KLF9, L3MBTL2, EVI1, MAFK, SP1, BCL11A, HNF4A, NR4A1, REST, ARID1A, ZBTB7A, ATF7, ZHX1, ASH2L, PHIP, TCF3, FOXP1, PRDM6, AATF, SMC3, ELL2, MLLT1, STAG1, SKI, TRP47, MEF2B, PPARG, FOXA2, MTA3, CREM, CHD2, EBF1, E2F8, ZNF600, ZNF692, GTF2B, MAFF, WT1, FOXF1, ZNF574, MEF2C, HOXB13, ZNF318, ZNF589, KDM1A, RELA, YY1, JUNB, ZNF148, ISL1, ZNF830, ZIC2, HIF1A, ZFP36, TCF4, OTX2, GATA3, BRCA1, BATF, SP140, TAL1, MAX, SPIB, ZNF143, MTA1, HAND2, ZFP69B, KLF4, SP7, CEBPG, NR2F2, TCF7L2, NR2F1, TP53, ZBTB6, MED, NFKB1, PHOX2B, ELF3, BRD2, KAT8, TBX21, AR, TAF1, ZBTB16, ZBTB40, RXR, ZNF324, YAP1, EGR1, HEXIM1, ZBTB26, RNF2, IKZF2, SCRT1, BRD4, NR1H3, NCOR1, JUND, MAZ, ILF3, IRF9, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): MX1,ABCG1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 1
- Number of somatic mutations (non-coding): 0
- Related genes and loops