- Basic information
- CohesinDB ID: CDBP00420270
- Locus: chr21-42200921-42202906
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Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE67783, GSE72082, GSE86191, GSE98367, GSE111913, ENCSR404BPV, GSE120943, ENCSR198ZYJ, ENCSR153HNT, GSE68388, ENCSR703TNG
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Cell type: MCF-7, Macrophage, HCT-116, Monocytes, Neurons-H1, RT-112, K-562, Liver, HSPC, HuCC-T1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.889
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
94% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 46%,
"14_ReprPCWk": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, FOXO1, SKI, POU2F2, BCL6, PPARG, ZSCAN5D, LDB1, MYCN, CBX3, CEBPA, MEIS2, ZFX, XBP1, ZBTB17, WT1, ZBTB48, CTBP1, SMAD3, GTF2B, SMC1A, ERG3, PBX2, CDK9, ERG2, ZFHX2, SMARCC1, YY1, RELA, ZNF148, ATF3, RUNX2, MYC, BRG1, ZNF341, SP140, ZIC2, HIF1A, GRHL3, ZFP36, GATA3, ZNF48, TAL1, TP63, GATA1, SMARCB1, ZNF143, CDK8, CRY1, MED1, JMJD1C, SP7, NCOA3, CEBPB, MYB, SCRT2, NR2F1, EZH2, VEZF1, ESR1, PKNOX1, TP73, NCOA1, TP53, OCA2, EGR2, GABPB1, CTCF, BCL11A, GSPT2, LMO1, AR, REST, ZNF479, ARID1A, HSF1, RNF2, HNRNPLL, BRD4, ZNF528, MAZ, SMC3, STAG1, EED
- Target gene symbol (double-evidenced CRMs): MX1,ABCG1
- Function elements
- Human SNPs: Eating_disorder_in_bipolar_disorder
- Number of somatic mutations (coding): 25
- Number of somatic mutations (non-coding): 0
- Related genes and loops