- Basic information
- CohesinDB ID: CDBP00420271
- Locus: chr21-42208748-42210810
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Data sourse: ENCSR895JMI, ENCSR853VWZ, GSE206145-GSE177045, GSE67783, GSE86191, ENCSR944ZCT, ENCSR501LQA, GSE98367, ENCSR768DOX, GSE101921, ENCSR981FDC, ENCSR247LSH, ENCSR000EDE, ENCSR153HNT, ENCSR620NWG, ENCSR748MVX, ENCSR000ECS
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Cell type: MCF-7, HCT-116, A-549, HCAEC, HeLa-S3, K-562, HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 7% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: SA1,Rad21,SMC1,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
94% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 46%,
"14_ReprPCWk": 27%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, SOX2, XBP1, FOXA1, CHD7, TEAD1, ETV1, NFE2L2, ESR1, CTCF, JUN, TCF12, EP300, SMC1, TEAD4, TFAP2C, GLIS1, POU2F2, CHD8, ZNF263, MYCN, POU5F1, TOP2A, ZBTB48, DUX4, HOXC5, ERG, ETS1, MYC, SMARCA4, GRHL3, NKX2-1, GABPA, STAT3, XRCC5, PRDM14, IKZF1, HNRNPH1, NR3C1, ESRRA, CEBPB, CREB1, GRHL2, SPI1, GATA2, NR2C2, NCOA2, RUNX1, SMC1A, CBX1, AFF4, ZFX, SIN3A, SMAD3, ERG3, ZNF18, SMARCC1, CREBBP, PBX4, ARNT, HMGB2, ETV6, FOS, MED1, TFAP2A, HNF4A, REST, ARID1A, ZHX1, CTBP2, SMC3, STAG1, TBL1X, FOXA2, WT1, FOXF1, YY1, RELA, SP140, HIF1A, GATA3, TAL1, NRIP1, NCOA3, NR2F2, NR2F1, TCF7L2, ZNF334, ELF3, ARRB1, AR, HSF1, ZBTB26, BRD4, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): MX1,ABCG1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 14
- Number of somatic mutations (non-coding): 0
- Related genes and loops