- Basic information
- CohesinDB ID: CDBP00420274
- Locus: chr21-42214383-42215748
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Data sourse: GSE111913, GSE67783, GSE86191
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Cell type: RT-112, HCT-116, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.967
- Subunit: SA1,Rad21,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
94% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 42%,
"14_ReprPCWk": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: MBD3, FOXO1, TRIM25, PGR, ZNF391, FOSL1, ZNF660, SOX2, PATZ1, FOXA1, HLF, SUZ12, RING1B, UBTF, MLL4, ZFHX2, RXRB, PBX2, TFAP4, HDGF, ATF3, CDK7, ZFP64, ZNF362, CTCFL, CHD7, ZBTB44, IKZF3, PRDM1, ZNF207, MORC2, CBFB, ZNF273, ZNF189, SMARCE1, PAX5, TP63, MITF, HDAC3, SFPQ, ZNF467, MAF, ZNF629, KLF5, TEAD1, TRIM28, ELF1, KLF6, SNAI2, LMO2, ESR1, OCA2, MED26, SAP30, PITX3, ZNF217, ZNF561, CTCF, TCF12, EP300, KLF1, BAF155, ZBTB20, MNT, GATA6, LMO1, RYBP, DPF2, E2F6, TRIM24, IRF4, CEBPA, ZNF674, ZNF423, ZNF512B, E2F1, ZNF677, SMC1, TEAD4, GTF2F1, PDX1, TFAP2C, EED, RBPJ, JARID2, GLIS1, POU2F2, NANOG, BRD1, ZSCAN5D, MYCN, BRD3, TOP2A, POU5F1, RUNX1T1, CTBP1, MTA2, ZBTB17, ZBTB48, ZSCAN5A, STAT1, ZSCAN21, ZNF317, DDX5, NBN, ERG2, SP4, TBP, ERG, HOXC5, PBX1, ASCL1, OGG1, ZBTB8A, ETS1, MYC, ZNF341, SMARCA4, RFX1, KDM4A, RAD21, GRHL3, RXRA, NKX2-1, GABPA, STAT3, NKX3-1, ZNF398, IKZF1, NFE2, PRDM14, ZNF639, RCOR1, VDR, NR3C1, ESRRA, ZNF750, STAT5B, KMT2A, ZBTB11, CREB1, EZH2, KLF8, GRHL2, FEZF1, GABPB1, PHF8, ZHX2, SPI1, KLF17, ZNF202, PCBP1, HDAC2, GATA2, ZBTB14, GATAD2B, MXD3, FLI1, HCFC1, MXI1, SMARCA5, RELB, MRTFB, NFYB, ZNF554, ZNF76, NFIL3, PTBP1, RUNX1, BCL6, SMC1A, CBX1, EZH2phosphoT487, SIRT6, NKX2-2, ZNF335, ZFX, SIN3A, AFF4, ZNF534, SMAD3, ERG3, CBX8, TRIM22, SMARCC1, PRDM10, CREBBP, ZNF384, RARA, CBX4, TAF15, ZNF35, OSR2, ZNF184, SP3, ARNT, BACH1, NRF1, ZBTB10, PBX4, ATF2, ZEB2, NFYA, SMAD4, PBX3, NCAPH2, SP2, FOS, CHD1, SMARCB1, MAFB, CDK8, MED1, ZEB1, TEAD3, KDM6B, ZXDB, MYB, SCRT2, PIAS1, ZNF3, NR1H2, KLF9, L3MBTL2, SETDB1, SREBF2, EVI1, ZNF22, TBX5, USF1, SP1, BCL11A, TFAP2A, MAFK, HNF4A, ARID2, REST, ZBTB7A, ZHX1, ATF7, ASH2L, HNRNPLL, CTBP2, PHIP, MBD2, BCOR, GLIS2, TCF3, AATF, FOXP1, SMC3, NCOR2, STAG1, STAG2, CXXC4, HMGB1, ZNF394, MLLT1, TRP47, CBFA2T2, NFATC3, MEF2B, FOXA2, AGO1, RBBP5, CHD2, SS18, HDAC6, ZNF600, ZNF692, GTF2B, WT1, ZNF30, ZBTB33, CDK9, HOXB13, KDM1A, YY1, RELA, TARDBP, BRG1, BRCA1, SP140, ZIC2, HIF1A, PCGF1, SKIL, GATA3, KLF15, TAL1, MAX, MAF1, NRIP1, GATA1, MTA1, ZNF143, HAND2, PLAG1, CBX2, KLF4, BCL11B, SP7, NCOA3, ZNF592, NR2F1, TCF7L2, KDM5B, ZNF687, ZBTB6, TP53, PKNOX1, ZSCAN22, ELF3, BRD2, TBX21, BHLHE40, AR, TAF1, ZBTB40, RXR, ZNF324, EGLN2, ZNF366, HEXIM1, RB1, TFIIIC, HSF1, RNF2, ZBTB26, BRD4, IKZF2, NCOR1, NR1H3, SCRT1, MAZ, ZSCAN23, ZNF24, AHR
- Target gene symbol (double-evidenced CRMs): ABCG1,MX1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 11
- Number of somatic mutations (non-coding): 11
- Related genes and loops