- Basic information
- CohesinDB ID: CDBP00420277
- Locus: chr21-42223160-42224581
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Data sourse: GSE206145-GSE177045, GSE67783, ENCSR000BKV, GSE72082, GSE86191, GSE62063, ENCSR703TNG, GSE25021, GSE50893
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Cell type: MCF-7, HCT-116, K-562, HSPC, GM18486, Ramos
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 3% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: NIPBL,SA1,Rad21,Mau2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
94% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 38%,
"14_ReprPCWk": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, PGR, SOX2, NME2, FOXA1, SUZ12, ZNF90, CHD7, PRDM1, ZNF189, TEAD1, TRIM28, ESR1, MLL, USF2, CTCF, JUN, SMC1, PDX1, TFAP2C, JARID2, GLIS1, ZNF263, POU5F1, MYCN, ZBTB17, ZBTB48, ZSCAN5A, STAT1, ERG, PBX1, ETS1, MYC, SMARCA4, RAD21, GABPA, APC, PRDM14, IKZF1, NR3C1, CEBPB, KMT2A, EBF3, SPI1, HDAC2, GATA2, RUNX1, SMC1A, BCL6, CBX1, SIN3A, ZFX, ZNF534, NOTCH1, FOS, MYB, REST, ASH2L, PHIP, TCF3, SMC3, NCOR2, STAG1, FOXA2, EBF1, SS18, NFATC1, WT1, ZNF662, RELA, BRG1, SP140, TCF4, GATA3, TAL1, NRIP1, ZNF143, HAND2, PLAG1, NR2F2, PKNOX1, ZNF334, NFKB1, MYOD1, AR, ZBTB42, HSF1, BRD4, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): MX1,ABCG1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 25
- Number of somatic mutations (non-coding): 5
- Related genes and loops
- Related gene:
ENSG00000157601,
ENSG00000160179,
- Related loop:
chr21:33200000-33225000~~chr21:42225000-42250000,
chr21:38225000-38250000~~chr21:42225000-42250000,
chr21:41425000-41450000~~chr21:42200000-42225000,
chr21:41850000-41875000~~chr21:42225000-42250000,
chr21:42125000-42150000~~chr21:42225000-42250000,
chr21:42200000-42225000~~chr21:42800000-42825000,
chr21:42218352-42220994~~chr21:42231997-42235488,
chr21:42218680-42222703~~chr21:42232839-42235624,
chr21:42225000-42250000~~chr21:42525000-42550000,
chr21:42225000-42250000~~chr21:43350000-43375000,
chr21:42225000-42250000~~chr21:44250000-44275000,