Deatailed information for cohesin site CDBP00420278

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  • Basic information
  • CohesinDB ID: CDBP00420278
  • Locus: chr21-42227795-42229175
  • Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, ENCSR000ECS, GSE103477, GSE25021, GSE108869, ENCSR917QNE, GSE93080, ENCSR000DZP, GSE67783, GSE86191, GSE138405, GSE101921, GSE206145-NatGen2015, GSE120943, GSE112028, GSE98367, GSE85526, GSE62063, ENCSR247LSH, ENCSR000BMY, ENCSR620NWG, ENCSR767DFK, GSE55407, ENCSR853VWZ, GSE111913, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE50893, GSE126755, ENCSR748MVX, GSE38411
  • Cell type: RH4, GM10847, Liver, HuCC-T1, GM2630, Fibroblast, HEKn, HeLa-S3, GM2255, K-562, BCBL-1, GM18486, SNYDER, Monocytes, GM12878, GM2588, RT-112, HeLa-Tet-On, THP-1, Macrophage, Ramos, MCF-7, GM12892, Hela-Kyoto, HCT-116, A-549, HCAEC, Neutrophil, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 12% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.678
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 94% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "7_Enh": 42%, "14_ReprPCWk": 19%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, MLL4, KDM3A, HDGF, THAP1, ZBTB44, IKZF3, ZNF429, PAX5, TEAD1, LMO2, OCA2, MED26, HDAC8, ZNF561, ARID5B, SOX5, PAX8, DEK, E2F4, KMT2B, GATAD2A, JARID2, NANOG, BRD3, ZNF263, POU5F1, CTBP1, ERF, DUX4, STAT1, SAP130, ERG, ZBTB21, ZNF597, NFKB2, ZBTB8A, EZH1, SMARCA4, RFX1, ZNF398, RCOR1, CD74, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, KLF17, ZNF257, GATA2, MXD3, SIX2, FLI1, HCFC1, MXI1, ZNF785, RELB, RUNX1, HDAC1, CEBPA, IRF3, NKX2-2, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, TFDP1, ATF2, FOXM1, SP2, SMARCB1, TERF1, PML, PIAS1, NR1H2, EVI1, STAT5A, GSPT2, IKZF5, RBM25, NFATC3, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, CHD2, SS18, PAF1, WT1, MEF2C, JUNB, ZFP36, TCF4, BATF, MAF1, SPIB, PLAG1, KLF4, BCL11B, MED, EGR2, ELF3, RXR, EGLN2, ZNF366, HSF1, NCOR1, ZBTB26, SCRT1, ILF3, NR1H3, FOSL1, ZNF660, XBP1, PBX2, ATF3, ZC3H8, ZFP64, RUNX3, CBFB, TP63, ZSCAN4, MITF, BACH2, JMJD1C, MAF, ELF1, ZNF573, RBM39, SNAI2, JUN, CTCF, TAF3, LMO1, ZBTB20, MNT, DPF2, RYBP, IRF4, PDX1, RBPJ, TFAP2C, MTA2, ZBTB17, ZBTB48, ZSCAN21, SRF, DDX5, NBN, PBX1, KDM4A, RXRA, BATF3, NKX3-1, PRDM14, TERF2, VDR, NR3C1, ESRRA, STAT5B, KMT2A, TBL1XR1, GRHL2, EBF3, ZBTB14, SMARCA5, NFIL3, THAP11, LDB1, EZH2phosphoT487, AFF4, SOX13, SP3, DAXX, ARNT, BACH1, ZNF48, PRDM9, ZEB2, NFYA, ETV6, PBX3, ZNF10, MAFB, NCAPH2, TEAD3, ZXDB, KLF9, TBX5, USF1, BCL11A, SP1, ZNF479, ATF7, ASH2L, ZNF548, GLIS2, PRDM6, SMC3, MLLT1, STAG2, STAG1, ZNF394, TRP47, AGO1, MTA3, EBF1, MEIS1, MAFF, BCL3, ZKSCAN1, KDM1A, BRG1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, MTA1, CBX2, ZNF141, TP53, ZNF334, NFKB1, ZSCAN22, ZNF140, BRD2, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, ZSCAN23, TBX2, PGR, CBX5, FANCL, SOX2, PATZ1, RING1B, TFAP4, BMI1, CHD7, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, SAP30, KLF1, SOX9, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, ZMYND8, ERG2, SP4, TBP, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, GFI1, EZH2, PHF8, SPI1, PCBP1, HDAC2, INTS13, GATAD2B, NFYB, ZNF554, ETV5, BCL6, SIN3A, ERG3, MEF2A, RARA, CREBBP, NFYC, ZNF35, TAF15, SMAD4, CBFA2T3, CDK8, ZEB1, ZMYM3, MAFK, NR4A1, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, RELA, TARDBP, SKIL, MAX, GFI1B, NR2F1, NEUROG2, KDM5B, TCF7L2, PKNOX1, MYOD1, T, AR, ZNF324, HEXIM1, AHR, FOSL2, DMAP1, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, LYL1, NFIC, CTCFL, PRDM1, MECOM, HDAC3, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, MLL, USF2, TCF12, EP300, BAF155, GATA6, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, EHMT2, EED, CHD8, BRD1, MYCN, RUNX1T1, CDK7, ARID3A, ASCL1, ZNF341, RAD21, GRHL3, PROX1, XRCC5, ZNF614, NFE2, ZNF750, FEZF1, TFE3, EHF, IRF1, ZGPAT, ZNF789, ZNF766, MRTFB, PTBP1, SMC1A, CBX1, MAFG, SIRT6, ZNF335, ZFX, ZNF534, FIP1L1, SMAD3, CBX8, TWIST1, PRPF4, NOTCH1, RUNX2, SMAD2, GATA4, OSR2, ZNF184, PBX4, NRF1, NR2C1, FOS, CHD1, SUPT5H, MED1, KDM6B, MYB, CEBPD, SCRT2, VEZF1, L3MBTL2, SETDB1, NIPBL, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, SKI, PAX7, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, CDK9, HOXB13, YY1, BRCA1, SP140, ZNF610, HIF1A, BHLHE22, ZNF519, ZNF449, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF687, BHLHE40, NFKBIZ, TAF1, ZBTB40, ZBTB42, MYNN, CLOCK, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): PRDM15,ABCG1,SLC37A1,UMODL1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 45
  • Number of somatic mutations (non-coding): 0
  • Related genes and loops
  • Related gene: ENSG00000141956, ENSG00000177398, ENSG00000160179, ENSG00000160190,
  • Related loop: chr21:33200000-33225000~~chr21:42225000-42250000, chr21:38225000-38250000~~chr21:42225000-42250000, chr21:41425000-41450000~~chr21:42200000-42225000, chr21:41850000-41875000~~chr21:42225000-42250000, chr21:42125000-42150000~~chr21:42225000-42250000, chr21:42163341-42165646~~chr21:42232057-42235346, chr21:42187387-42189528~~chr21:42232081-42235327, chr21:42200000-42225000~~chr21:42800000-42825000, chr21:42218352-42220994~~chr21:42231997-42235488, chr21:42218680-42222703~~chr21:42232839-42235624, chr21:42225000-42250000~~chr21:42525000-42550000, chr21:42225000-42250000~~chr21:43350000-43375000, chr21:42225000-42250000~~chr21:44250000-44275000, chr21:42232057-42235346~~chr21:42257750-42260047,
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