- Basic information
- CohesinDB ID: CDBP00420281
- Locus: chr21-42242225-42243536
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Data sourse: GSE67783, GSE86191, GSE98367, GSE206145-NatGen2015, ENCSR000BMY, ENCSR153HNT, GSE120943
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Cell type: Fibroblast, HCT-116, Monocytes, GM12878, K-562, HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.922
- Subunit: SA1,Rad21,SA2,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
94% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 32%,
"14_ReprPCWk": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, POU2F2, BCL6, MEF2B, MTA3, MYCN, SOX2, ZFX, ZNF600, MTA2, NME2, ZBTB48, ZSCAN5A, WT1, ZNF30, ZNF770, ERG3, DDX5, ZNF823, CDK9, YY1, RELA, HDGF, ZNF384, TARDBP, PBX1, CREBBP, TAF15, MYC, CDK6, OGG1, RUNX3, SP140, ARNT, ZIC2, TAL1, MAX, PAX5, TP63, ZSCAN4, IKZF1, MED1, BACH2, NR3C1, CEBPB, KLF5, NCOA3, ZNF121, KMT2A, MYB, CREB1, BCLAF1, STAG1, TFAP2C, ESR1, MED, CTCF, TCF12, TBX21, BHLHE40, DPF2, ARID1A, GATAD2B, ATF7, HSF1, IKZF2, BRD4, TCF3, FOXP1, BCOR, MAZ, RELB, ZNF528, SMC3, MLLT1, AHR
- Target gene symbol (double-evidenced CRMs): ABCG1,PRDM15,SLC37A1,UMODL1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 60
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000141956,
ENSG00000177398,
ENSG00000160179,
ENSG00000160190,
- Related loop:
chr21:33200000-33225000~~chr21:42225000-42250000,
chr21:38225000-38250000~~chr21:42225000-42250000,
chr21:41850000-41875000~~chr21:42225000-42250000,
chr21:42125000-42150000~~chr21:42225000-42250000,
chr21:42225000-42250000~~chr21:42525000-42550000,
chr21:42225000-42250000~~chr21:43350000-43375000,
chr21:42225000-42250000~~chr21:44250000-44275000,