- Basic information
- CohesinDB ID: CDBP00420284
- Locus: chr21-42245409-42246173
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Data sourse: GSE67783, GSE86191, GSE111913, ENCSR000BLY, GSE206145, GSE206145-NatGen2015, ENCSR000EHX
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Cell type: RPE, Fibroblast, HCT-116, SK-N-SH, RT-112, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: SA1,Rad21,SA2,SMC1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
94% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"7_Enh": 25%,
"5_TxWk": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, GLIS1, EZH2phosphoT487, MAFG, BCL6, ZNF263, MYCN, NKX2-2, SS18, ZFX, KDM4C, XBP1, ZBTB17, ZBTB48, WT1, STAT1, FOXA1, MAFF, TET2, ERG3, PATZ1, ERG2, ZFHX2, TWIST1, KDM1A, YY1, RELA, ASCL1, ZNF341, ATF3, MYC, SMARCA4, SP140, GRHL3, BACH1, TCF4, NKX2-1, GATA3, BHLHE22, MAX, MAFB, NKX3-1, GATA1, NFE2, RCOR1, HAND2, BACH2, MED1, KLF4, PDX1, TEAD3, SPDEF, KLF5, ESR1, TP53, PITX3, C11orf30, ZNF334, TEAD4, EBF3, EGR2, CTCF, MAFK, USF1, KLF1, SPI1, GATA6, GATA2, E2F6, ZNF479, RFX5, HSF1, MXI1, BRD4, CTBP2, MAZ, SMC3, STAG1, ZNF316
- Target gene symbol (double-evidenced CRMs): ABCG1,UMODL1,SLC37A1,PRDM15
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 45
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000141956,
ENSG00000177398,
ENSG00000160179,
ENSG00000160190,
- Related loop:
chr21:33200000-33225000~~chr21:42225000-42250000,
chr21:38225000-38250000~~chr21:42225000-42250000,
chr21:41425000-41450000~~chr21:42250000-42275000,
chr21:41500000-41525000~~chr21:42250000-42275000,
chr21:41850000-41875000~~chr21:42225000-42250000,
chr21:41925000-41950000~~chr21:42250000-42275000,
chr21:42125000-42150000~~chr21:42225000-42250000,
chr21:42125000-42150000~~chr21:42250000-42275000,
chr21:42150000-42175000~~chr21:42250000-42275000,
chr21:42225000-42250000~~chr21:42525000-42550000,
chr21:42225000-42250000~~chr21:43350000-43375000,
chr21:42225000-42250000~~chr21:44250000-44275000,