- Basic information
- CohesinDB ID: CDBP00420287
- Locus: chr21-42251485-42252063
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Data sourse: GSE206145-GSE177045, GSE111913, GSE67783, GSE86191
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Cell type: MCF-7, RT-112, HCT-116, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: Mau2,SA1,Rad21,SMC1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
88% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"14_ReprPCWk": 26%,
"7_Enh": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, ZNF660, MEIS2, FOXA1, SUZ12, RXRB, ZFHX2, HNRNPK, TFAP4, HDGF, ATF3, NFIC, CTCFL, PRDM1, ZNF444, CBFB, MXD4, PAX5, TP63, MITF, ZNF780A, MAF, JMJD1C, TEAD1, TRIM28, BCLAF1, ELF1, ZNF573, LMO2, ESR1, OCA2, USF2, ZNF561, CTCF, JUN, TCF12, EP300, MNT, LMO1, PAX8, IRF4, RFX5, RAD51, ZNF423, ZNF512B, E2F1, ZNF528, SMC1, FOXA3, GATAD2A, PDX1, TFAP2C, RBPJ, GLIS1, YBX1, POU2F2, CHD8, BRD1, NANOG, ZNF263, MYCN, TOP2A, POU5F1, CDK7, CTBP1, ZNF317, ZBTB17, ZBTB48, ZSCAN5A, STAT1, RUNX1T1, NONO, SRF, GATAD1, SAP130, NBN, ARID3A, ERG, ASCL1, ZNF341, ETS1, MYC, EZH1, SMARCA4, RAD21, GRHL3, NKX2-1, GABPA, STAT3, XRCC5, ZNF614, PRDM14, IKZF1, MIER3, DNMT3B, ZNF639, NR2F6, VDR, NFE2, ZNF285, ESRRA, SRSF3, CEBPB, STAT5B, CREB1, EZH2, ARHGAP35, CBX1, EBF3, GABPB1, PHF8, SPI1, TFE3, MIXL1, HDAC2, SSRP1, GATAD2B, SIX2, FLI1, HCFC1, MXI1, SMARCA5, MRTFB, NFIL3, ETV5, RUNX1, THAP11, BCL6, SMC1A, MAFG, NKX2-2, HDAC1, CRY1, AFF4, ZFX, ZNF534, POU4F2, CEBPA, SMAD3, PCBP2, TET2, ERG3, ZNF770, ZNF654, TRIM22, TWIST1, PRDM10, CREBBP, ZBTB2, NOTCH1, ZNF35, CDK6, OSR2, NRF1, ARNT, TFDP1, ATF2, PRDM9, ZNF48, NFYA, SMAD4, MAFB, FOS, CHD1, HMGXB4, MED1, TEAD3, MYB, SMAD1, ZNF3, C11orf30, SREBF2, KLF16, MAFK, BCL11A, USF1, IKZF5, REST, ZNF479, ATF7, HOXA9, BCOR, TCF3, GLIS2, FOXP1, AATF, SMC3, NCOR2, STAG1, MLLT1, STAG2, SKI, TRP47, CBFA2T2, MEF2B, PPARG, FOXA2, ZNF207, EBF1, CREM, SS18, MTA3, ZNF44, ZNF600, MIER2, WT1, MAFF, ZNF574, ZBTB33, CDK9, ZNF580, ZKSCAN1, KDM1A, YY1, RELA, TARDBP, NEUROD1, AHR, BRG1, SP140, ZIC2, HIF1A, SKIL, ZFP36, OTX2, GATA3, TCF4, BATF, TAL1, MAX, ZNF143, HAND2, PLAG1, KLF4, ZNF592, GFI1B, NR2F2, BAP1, ZNF512, NR2F1, TCF7L2, NEUROG2, KDM5B, TP53, PKNOX1, ZBTB6, ZNF547, MYOD1, ELF3, BRD2, TBX21, BHLHE40, AR, PAX3-FOXO1, ZNF579, RXR, ZNF324, EGLN2, ZBTB42, ZNF366, RB1, HSF1, NCOR1, IKZF2, BRD4, JUND, ILF3, CLOCK, CUX1, MAZ, ZBTB26, ZNF316, FOSL2
- Target gene symbol (double-evidenced CRMs): MX1,ABCG1,TMPRSS2,UMODL1,C2CD2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 25
- Number of somatic mutations (non-coding): 5
- Related genes and loops
- Related gene:
ENSG00000157601,
ENSG00000184012,
ENSG00000157617,
ENSG00000177398,
ENSG00000160179,
- Related loop:
chr21:33200000-33225000~~chr21:42225000-42250000,
chr21:38225000-38250000~~chr21:42225000-42250000,
chr21:41425000-41450000~~chr21:42250000-42275000,
chr21:41500000-41525000~~chr21:42250000-42275000,
chr21:41850000-41875000~~chr21:42225000-42250000,
chr21:41925000-41950000~~chr21:42250000-42275000,
chr21:42125000-42150000~~chr21:42225000-42250000,
chr21:42125000-42150000~~chr21:42250000-42275000,
chr21:42150000-42175000~~chr21:42250000-42275000,
chr21:42225000-42250000~~chr21:42525000-42550000,
chr21:42225000-42250000~~chr21:43350000-43375000,
chr21:42225000-42250000~~chr21:44250000-44275000,