- Basic information
- CohesinDB ID: CDBP00420289
- Locus: chr21-42254531-42254923
-
Data sourse: GSE206145-GSE177045, GSE98367
-
Cell type: MCF-7, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 0% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.978
- Subunit: Mau2,SMC1
-
CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
88% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"7_Enh": 27%,
"14_ReprPCWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, ZNF660, MEIS2, FOXA1, SUZ12, RXRB, ZFHX2, HNRNPK, TFAP4, HDGF, ATF3, NFIC, CTCFL, PRDM1, ZNF444, CBFB, MXD4, PAX5, TP63, MITF, ZNF780A, MAF, JMJD1C, TEAD1, TRIM28, BCLAF1, ELF1, ZNF573, LMO2, ESR1, OCA2, USF2, ZNF561, CTCF, JUN, TCF12, EP300, MNT, LMO1, PAX8, IRF4, RFX5, RAD51, ZNF423, ZNF512B, E2F1, ZNF528, SMC1, FOXA3, GATAD2A, PDX1, TFAP2C, RBPJ, GLIS1, YBX1, POU2F2, CHD8, BRD1, NANOG, ZNF263, MYCN, TOP2A, POU5F1, CDK7, CTBP1, ZNF317, ZBTB17, ZBTB48, ZSCAN5A, STAT1, RUNX1T1, NONO, SRF, GATAD1, SAP130, NBN, ARID3A, ERG, ASCL1, ZNF341, ETS1, MYC, EZH1, SMARCA4, RAD21, GRHL3, NKX2-1, GABPA, STAT3, XRCC5, ZNF614, PRDM14, IKZF1, MIER3, DNMT3B, ZNF639, NR2F6, VDR, NFE2, ZNF285, ESRRA, SRSF3, CEBPB, STAT5B, CREB1, EZH2, ARHGAP35, CBX1, EBF3, GABPB1, PHF8, SPI1, TFE3, MIXL1, HDAC2, SSRP1, GATAD2B, SIX2, FLI1, HCFC1, MXI1, SMARCA5, MRTFB, NFIL3, ETV5, RUNX1, THAP11, BCL6, SMC1A, MAFG, NKX2-2, HDAC1, CRY1, AFF4, ZFX, ZNF534, POU4F2, CEBPA, SMAD3, PCBP2, TET2, ERG3, ZNF770, ZNF654, TRIM22, TWIST1, PRDM10, CREBBP, ZBTB2, NOTCH1, ZNF35, CDK6, OSR2, NRF1, ARNT, TFDP1, ATF2, PRDM9, ZNF48, NFYA, SMAD4, MAFB, FOS, CHD1, HMGXB4, MED1, TEAD3, MYB, SMAD1, ZNF3, C11orf30, SREBF2, KLF16, MAFK, BCL11A, USF1, IKZF5, REST, ZNF479, ATF7, HOXA9, BCOR, TCF3, GLIS2, FOXP1, AATF, SMC3, NCOR2, STAG1, MLLT1, STAG2, SKI, TRP47, CBFA2T2, MEF2B, PPARG, FOXA2, ZNF207, EBF1, CREM, SS18, MTA3, ZNF44, ZNF600, MIER2, WT1, MAFF, ZNF574, ZBTB33, CDK9, ZNF580, ZKSCAN1, KDM1A, YY1, RELA, TARDBP, NEUROD1, AHR, BRG1, SP140, ZIC2, HIF1A, SKIL, ZFP36, OTX2, GATA3, TCF4, BATF, TAL1, MAX, ZNF143, HAND2, PLAG1, KLF4, ZNF592, GFI1B, NR2F2, BAP1, ZNF512, NR2F1, TCF7L2, NEUROG2, KDM5B, TP53, PKNOX1, ZBTB6, ZNF547, MYOD1, ELF3, BRD2, TBX21, BHLHE40, AR, PAX3-FOXO1, ZNF579, RXR, ZNF324, EGLN2, ZBTB42, ZNF366, RB1, HSF1, NCOR1, IKZF2, BRD4, JUND, ILF3, CLOCK, CUX1, MAZ, ZBTB26, ZNF316, FOSL2
- Target gene symbol (double-evidenced CRMs): MX1,UMODL1,TMPRSS2,C2CD2,ABCG1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 5
- Number of somatic mutations (non-coding): 1
- Related genes and loops
- Related gene:
ENSG00000157601,
ENSG00000184012,
ENSG00000157617,
ENSG00000177398,
ENSG00000160179,
- Related loop:
chr21:33200000-33225000~~chr21:42225000-42250000,
chr21:38225000-38250000~~chr21:42225000-42250000,
chr21:41425000-41450000~~chr21:42250000-42275000,
chr21:41500000-41525000~~chr21:42250000-42275000,
chr21:41850000-41875000~~chr21:42225000-42250000,
chr21:41925000-41950000~~chr21:42250000-42275000,
chr21:42125000-42150000~~chr21:42225000-42250000,
chr21:42125000-42150000~~chr21:42250000-42275000,
chr21:42144166-42146785~~chr21:42257788-42259761,
chr21:42144207-42146848~~chr21:42257747-42259915,
chr21:42144210-42146803~~chr21:42257794-42259803,
chr21:42144211-42146835~~chr21:42257776-42259795,
chr21:42144396-42146769~~chr21:42257874-42259616,
chr21:42144411-42146838~~chr21:42257750-42260047,
chr21:42144415-42146862~~chr21:42257791-42259828,
chr21:42144450-42146775~~chr21:42257861-42259727,
chr21:42144587-42146751~~chr21:42257937-42259543,
chr21:42144601-42146847~~chr21:42257791-42259910,
chr21:42144666-42146603~~chr21:42257998-42259702,
chr21:42144679-42146840~~chr21:42257801-42259871,
chr21:42144681-42146751~~chr21:42257798-42260906,
chr21:42144690-42146856~~chr21:42257772-42259645,
chr21:42144691-42147023~~chr21:42257772-42259840,
chr21:42144726-42146738~~chr21:42257878-42259619,
chr21:42144746-42146589~~chr21:42257982-42259586,
chr21:42144747-42146542~~chr21:42258014-42259527,
chr21:42144761-42146752~~chr21:42257787-42259818,
chr21:42144767-42146839~~chr21:42257930-42259773,
chr21:42144767-42146855~~chr21:42257917-42259640,
chr21:42144768-42146845~~chr21:42257753-42259725,
chr21:42144769-42146888~~chr21:42257959-42259654,
chr21:42144776-42146791~~chr21:42257930-42259659,
chr21:42144798-42146688~~chr21:42257985-42259687,
chr21:42144929-42146574~~chr21:42257974-42259612,
chr21:42144930-42146490~~chr21:42258020-42259519,
chr21:42150000-42175000~~chr21:42250000-42275000,
chr21:42162848-42165688~~chr21:42257772-42259840,
chr21:42163341-42165646~~chr21:42257750-42260047,
chr21:42163482-42166809~~chr21:42257798-42260906,
chr21:42163513-42165594~~chr21:42257950-42259521,
chr21:42163547-42165689~~chr21:42257801-42259871,
chr21:42163548-42165686~~chr21:42257776-42259795,
chr21:42163554-42165689~~chr21:42257870-42259821,
chr21:42163560-42165678~~chr21:42257791-42259828,
chr21:42163562-42165662~~chr21:42257753-42259725,
chr21:42163573-42165597~~chr21:42257861-42259727,
chr21:42163578-42165654~~chr21:42257852-42259851,
chr21:42163584-42165421~~chr21:42257930-42259773,
chr21:42163593-42165452~~chr21:42257772-42259645,
chr21:42163594-42165538~~chr21:42257903-42260904,
chr21:42163609-42165687~~chr21:42257930-42259659,
chr21:42163637-42165569~~chr21:42257874-42259616,
chr21:42163647-42165636~~chr21:42257777-42259668,
chr21:42163649-42165427~~chr21:42257899-42259660,
chr21:42163687-42165447~~chr21:42257787-42259818,
chr21:42163697-42165455~~chr21:42257924-42259631,
chr21:42163698-42165607~~chr21:42257794-42259803,
chr21:42163710-42165639~~chr21:42257974-42259612,
chr21:42163727-42165624~~chr21:42257998-42259702,
chr21:42163772-42165364~~chr21:42257985-42259687,
chr21:42163782-42165494~~chr21:42257791-42259910,
chr21:42163825-42165601~~chr21:42257982-42259586,
chr21:42163825-42165615~~chr21:42258014-42259527,
chr21:42163825-42165673~~chr21:42257917-42259640,
chr21:42163831-42165511~~chr21:42258055-42259516,
chr21:42163847-42165532~~chr21:42257970-42259534,
chr21:42163884-42165279~~chr21:42257979-42259471,
chr21:42163884-42165512~~chr21:42257959-42259585,
chr21:42163919-42165460~~chr21:42258097-42259645,
chr21:42211481-42212968~~chr21:42257750-42260047,
chr21:42225000-42250000~~chr21:42525000-42550000,
chr21:42225000-42250000~~chr21:43350000-43375000,
chr21:42225000-42250000~~chr21:44250000-44275000,
chr21:42232057-42235346~~chr21:42257750-42260047,