- Basic information
- CohesinDB ID: CDBP00420290
- Locus: chr21-42255135-42266245
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Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE130140, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
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Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CUTLL1, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, Ramos, GM19238, HeLa, BGO3, TC-71, Neutrophil, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 77% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.144
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
88% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"7_Enh": 31%,
"5_TxWk": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, HMG20A, ZSCAN5C, NME2, FOXA1, HLF, SUZ12, RBFOX2, RXRB, MLL4, ZFHX2, TFAP4, HDGF, LYL1, ATF3, NFIC, CHD7, ATF4, CBFB, SMARCE1, TP63, HDAC3, ZNF467, JMJD1C, ZNF629, KLF5, TEAD1, TRIM28, ELF1, RBM39, KLF6, ETV1, ZNF217, ESR1, LMO2, HDAC8, CTCF, JUN, TCF12, BAF155, EP300, KLF1, MNT, SOX5, DPF2, TRIM24, NR5A2, SMC1, FOXA3, ZNF175, KMT2B, GATAD2A, EHMT2, TFAP2C, RBPJ, JARID2, YBX1, CHD8, BRD1, ZSCAN5D, MYCN, ZNF263, RUNX1T1, POU5F1, TOP2A, CTBP1, ZSCAN21, ZBTB17, ZBTB48, ZSCAN5A, ERF, ZNF205, GATAD1, SAP130, ERG, ZBTB21, SMARCC2, ETS1, MYC, SMARCA4, ZNF671, RAD21, FOXP2, RXRA, PROX1, GABPA, APC, XRCC5, STAT3, NKX3-1, ZNF398, IKZF1, RCOR1, PRDM14, ZNF614, NFE2, VDR, DNMT3B, NR3C1, CEBPB, ESRRA, ZNF93, HNRNPL, KMT2A, CREB1, EZH2, BMPR1A, GRHL2, ZNF652, GABPB1, SPI1, KLF17, ZNF257, HDAC2, GATA2, INTS13, ZNF644, MXD3, FLI1, NR2C2, ZGPAT, HCFC1R1, MRTFB, NCOA2, ZNF554, NFIL3, ZIM3, PTBP1, ETV5, RUNX1, THAP11, CBX1, BCL6, HDAC1, SIRT6, CEBPA, AFF4, ZFX, SIN3A, ZNF335, SOX13, SMAD3, TET2, ERG3, SMARCC1, PRDM10, CREBBP, RARA, RUNX2, NFIB, ARNT, PBX4, ZBTB10, ZNF48, ATF2, SMAD4, ZEB2, FOS, SMARCB1, MED1, TEAD3, CEBPD, MYB, PIAS1, VEZF1, NR1H2, L3MBTL2, TBX5, EVI1, SREBF2, MAFK, BCL11A, TFAP2A, SP1, HNF4A, ARID2, IKZF5, ZBTB7A, ZNF479, NKX2-5, REST, ATF7, ASH2L, HNRNPLL, CTBP2, PHIP, MBD2, FOXP1, TCF3, GLIS2, AATF, SMC3, ELL2, STAG1, STAG2, ETV4, SKI, TRP47, CBFA2T2, FOXA2, MTA3, ZNF207, AGO1, SS18, NFATC1, ZNF600, ZSCAN16, ZNF692, WT1, FOXF1, ZNF580, HOXB13, KDM1A, YY1, RELA, ZNF148, JUNB, BRG1, MCM3, SP140, ZIC2, ZFP36, HIF1A, GATA3, TAL1, MAX, NRIP1, ZNF143, HAND2, TLE3, CEBPG, ZNF223, SP7, NCOA3, NR2F2, BAP1, ZFP69B, NR2F1, TCF7L2, KDM5B, TP53, PKNOX1, ZBTB6, ZNF334, NFKB1, ZNF165, EGR2, T, ELF3, KAT8, BHLHE40, AR, ARID4B, ZNF579, ZBTB40, YAP1, RXR, EGLN2, ZNF366, ZBTB42, ZBTB26, RNF2, HSF1, BRD4, JUND, CLOCK, CUX1, MAZ, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): ABCG1,MX1,C2CD2,TMPRSS2,UMODL1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 419
- Number of somatic mutations (non-coding): 1
- Related genes and loops
- Related gene:
ENSG00000157601,
ENSG00000184012,
ENSG00000157617,
ENSG00000177398,
ENSG00000160179,
- Related loop:
chr21:41425000-41450000~~chr21:42250000-42275000,
chr21:41500000-41525000~~chr21:42250000-42275000,
chr21:41925000-41950000~~chr21:42250000-42275000,
chr21:42125000-42150000~~chr21:42250000-42275000,
chr21:42144166-42146785~~chr21:42257788-42259761,
chr21:42144207-42146848~~chr21:42257747-42259915,
chr21:42144210-42146803~~chr21:42257794-42259803,
chr21:42144211-42146835~~chr21:42257776-42259795,
chr21:42144396-42146769~~chr21:42257874-42259616,
chr21:42144396-42146769~~chr21:42268874-42270578,
chr21:42144411-42146838~~chr21:42257750-42260047,
chr21:42144415-42146862~~chr21:42257791-42259828,
chr21:42144450-42146775~~chr21:42257861-42259727,
chr21:42144587-42146751~~chr21:42257937-42259543,
chr21:42144601-42146847~~chr21:42257791-42259910,
chr21:42144666-42146603~~chr21:42257998-42259702,
chr21:42144679-42146840~~chr21:42257801-42259871,
chr21:42144681-42146751~~chr21:42257798-42260906,
chr21:42144690-42146856~~chr21:42257772-42259645,
chr21:42144691-42147023~~chr21:42257772-42259840,
chr21:42144726-42146738~~chr21:42257878-42259619,
chr21:42144746-42146589~~chr21:42257982-42259586,
chr21:42144747-42146542~~chr21:42258014-42259527,
chr21:42144761-42146752~~chr21:42257787-42259818,
chr21:42144767-42146839~~chr21:42257930-42259773,
chr21:42144767-42146839~~chr21:42268678-42270523,
chr21:42144767-42146855~~chr21:42257917-42259640,
chr21:42144768-42146845~~chr21:42257753-42259725,
chr21:42144769-42146888~~chr21:42257959-42259654,
chr21:42144776-42146791~~chr21:42257930-42259659,
chr21:42144798-42146688~~chr21:42257985-42259687,
chr21:42144929-42146574~~chr21:42257974-42259612,
chr21:42144930-42146490~~chr21:42258020-42259519,
chr21:42150000-42175000~~chr21:42250000-42275000,
chr21:42162848-42165688~~chr21:42257772-42259840,
chr21:42163341-42165646~~chr21:42257750-42260047,
chr21:42163482-42166809~~chr21:42257798-42260906,
chr21:42163513-42165594~~chr21:42257950-42259521,
chr21:42163547-42165689~~chr21:42257801-42259871,
chr21:42163548-42165686~~chr21:42257776-42259795,
chr21:42163554-42165689~~chr21:42257870-42259821,
chr21:42163560-42165678~~chr21:42257791-42259828,
chr21:42163562-42165662~~chr21:42257753-42259725,
chr21:42163573-42165597~~chr21:42257861-42259727,
chr21:42163578-42165654~~chr21:42257852-42259851,
chr21:42163584-42165421~~chr21:42257930-42259773,
chr21:42163593-42165452~~chr21:42257772-42259645,
chr21:42163594-42165538~~chr21:42257903-42260904,
chr21:42163609-42165687~~chr21:42257930-42259659,
chr21:42163637-42165569~~chr21:42257874-42259616,
chr21:42163637-42165569~~chr21:42268874-42270578,
chr21:42163647-42165636~~chr21:42257777-42259668,
chr21:42163649-42165427~~chr21:42257899-42259660,
chr21:42163687-42165447~~chr21:42257787-42259818,
chr21:42163697-42165455~~chr21:42257924-42259631,
chr21:42163698-42165607~~chr21:42257794-42259803,
chr21:42163710-42165639~~chr21:42257974-42259612,
chr21:42163727-42165624~~chr21:42257998-42259702,
chr21:42163772-42165364~~chr21:42257985-42259687,
chr21:42163782-42165494~~chr21:42257791-42259910,
chr21:42163825-42165601~~chr21:42257982-42259586,
chr21:42163825-42165615~~chr21:42258014-42259527,
chr21:42163825-42165673~~chr21:42257917-42259640,
chr21:42163831-42165511~~chr21:42258055-42259516,
chr21:42163847-42165532~~chr21:42257970-42259534,
chr21:42163884-42165279~~chr21:42257979-42259471,
chr21:42163884-42165512~~chr21:42257959-42259585,
chr21:42163919-42165460~~chr21:42258097-42259645,
chr21:42211481-42212968~~chr21:42257750-42260047,
chr21:42232057-42235346~~chr21:42257750-42260047,
chr21:42262270-42264527~~chr21:42301297-42302783,