- Basic information
- CohesinDB ID: CDBP00420291
- Locus: chr21-42267072-42268447
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Data sourse: GSE67783, GSE98367
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Cell type: HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.978
- Subunit: SA1,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
88% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"7_Enh": 32%,
"5_TxWk": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, NME2, XBP1, FOXA1, TFAP4, HDGF, LYL1, ATF3, THAP1, ATF4, CBFB, MECOM, ZSCAN4, TP63, JMJD1C, MAF, KLF5, ELF1, TRIM28, TEAD1, LMO2, ESR1, MLL, CTCF, TCF12, JUN, KLF1, LMO1, ZNF776, PDX1, TFAP2C, ZNF263, MYCN, RUNX1T1, CDK7, ZBTB17, ZBTB48, DDX5, ERG, PBX1, ASCL1, ETS1, EZH1, MYC, SMARCA4, RAD21, GRHL3, GABPA, XRCC5, ZNF398, IKZF1, NFE2, DNMT3B, ZNF639, DACH1, NR3C1, CEBPB, ESRRA, ZNF750, KMT2A, EZH2, KLF8, SPI1, GATA2, FLI1, RUNX1, SMC1A, CBX1, CEBPA, ZFX, SMAD3, ZNF473, TET2, PRDM10, CREBBP, RARA, ZBTB2, ZNF384, RUNX2, NRF1, ZNF48, FOS, MYB, EVI1, BCL11A, NR4A1, POU2F3, HNRNPLL, TCF3, AATF, SMC3, STAG1, SKI, MTA3, EBF1, MEIS1, SS18, WT1, ZNF662, KDM1A, YY1, RELA, BRG1, SP140, ZIC2, HIF1A, GATA3, TAL1, MAX, GATA1, ZNF143, HAND2, CBX2, BCL11B, NR2F1, KDM5B, PKNOX1, PHOX2B, AR, ZBTB16, EGLN2, HSF1, BRD4, MAZ, ZNF24
- Target gene symbol (double-evidenced CRMs): TMPRSS2,C2CD2,ABCG1,MX1,UMODL1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 180
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000157601,
ENSG00000184012,
ENSG00000157617,
ENSG00000177398,
ENSG00000160179,
- Related loop:
chr21:41425000-41450000~~chr21:42250000-42275000,
chr21:41500000-41525000~~chr21:42250000-42275000,
chr21:41925000-41950000~~chr21:42250000-42275000,
chr21:42125000-42150000~~chr21:42250000-42275000,
chr21:42144396-42146769~~chr21:42268874-42270578,
chr21:42144767-42146839~~chr21:42268678-42270523,
chr21:42150000-42175000~~chr21:42250000-42275000,
chr21:42163637-42165569~~chr21:42268874-42270578,
chr21:42262270-42264527~~chr21:42301297-42302783,