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Basic information

CohesinDB ID: CDBP00420292

Locus: chr21-42268710-42270140

Data sourse: ENCSR000BTQ, GSE93080, GSE206145-GSE177045, GSE67783, GSE72082, GSE86191, GSE25021, GSE76893, GSE206145, GSE85526, GSE206145-NatGen2015, GSE68388, ENCSR703TNG, GSE131606, GSE50893, GSE115602

Cell type: GM19240, HuCC-T1, RPE, GM2630, Fibroblast, HEKn, GM12890, GM2255, GM18486, DKO, SNYDER, GM18505, GM12878, GM12891, GM19239, MCF-7, GM12892, HCT-116, GM19238, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 10% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.778

Subunit: Mau2,SA1,Rad21,SMC1

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 88% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 36%, "7_Enh": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, NME2, XBP1, FOXA1, TFAP4, HDGF, LYL1, ATF3, THAP1, ATF4, CBFB, MECOM, ZSCAN4, TP63, JMJD1C, MAF, KLF5, ELF1, TRIM28, TEAD1, LMO2, ESR1, MLL, CTCF, TCF12, JUN, KLF1, LMO1, ZNF776, PDX1, TFAP2C, ZNF263, MYCN, RUNX1T1, CDK7, ZBTB17, ZBTB48, DDX5, ERG, PBX1, ASCL1, ETS1, EZH1, MYC, SMARCA4, RAD21, GRHL3, GABPA, XRCC5, ZNF398, IKZF1, NFE2, DNMT3B, ZNF639, DACH1, NR3C1, CEBPB, ESRRA, ZNF750, KMT2A, EZH2, KLF8, SPI1, GATA2, FLI1, RUNX1, SMC1A, CBX1, CEBPA, ZFX, SMAD3, ZNF473, TET2, PRDM10, CREBBP, RARA, ZBTB2, ZNF384, RUNX2, NRF1, ZNF48, FOS, MYB, EVI1, BCL11A, NR4A1, POU2F3, HNRNPLL, TCF3, AATF, SMC3, STAG1, SKI, MTA3, EBF1, MEIS1, SS18, WT1, ZNF662, KDM1A, YY1, RELA, BRG1, SP140, ZIC2, HIF1A, GATA3, TAL1, MAX, GATA1, ZNF143, HAND2, CBX2, BCL11B, NR2F1, KDM5B, PKNOX1, PHOX2B, AR, ZBTB16, EGLN2, HSF1, BRD4, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): MX1,UMODL1,C2CD2,ABCG1,TMPRSS2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 18

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000157601, ENSG00000184012, ENSG00000157617, ENSG00000177398, ENSG00000160179,

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Deatailed information for cohesin site CDBP00420292