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Basic information

CohesinDB ID: CDBP00420293

Locus: chr21-42271071-42271815

Data sourse: GSE67783, ENCSR153HNT, GSE86191

Cell type: K-562, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 88% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 40%, "4_Tx": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, NME2, XBP1, FOXA1, TFAP4, HDGF, LYL1, ATF3, THAP1, ATF4, CBFB, MECOM, ZSCAN4, TP63, JMJD1C, MAF, KLF5, ELF1, TRIM28, TEAD1, LMO2, ESR1, MLL, CTCF, TCF12, JUN, KLF1, LMO1, ZNF776, PDX1, TFAP2C, ZNF263, MYCN, RUNX1T1, CDK7, ZBTB17, ZBTB48, DDX5, ERG, PBX1, ASCL1, ETS1, EZH1, MYC, SMARCA4, RAD21, GRHL3, GABPA, XRCC5, ZNF398, IKZF1, NFE2, DNMT3B, ZNF639, DACH1, NR3C1, CEBPB, ESRRA, ZNF750, KMT2A, EZH2, KLF8, SPI1, GATA2, FLI1, RUNX1, SMC1A, CBX1, CEBPA, ZFX, SMAD3, ZNF473, TET2, PRDM10, CREBBP, RARA, ZBTB2, ZNF384, RUNX2, NRF1, ZNF48, FOS, MYB, EVI1, BCL11A, NR4A1, POU2F3, HNRNPLL, TCF3, AATF, SMC3, STAG1, SKI, MTA3, EBF1, MEIS1, SS18, WT1, ZNF662, KDM1A, YY1, RELA, BRG1, SP140, ZIC2, HIF1A, GATA3, TAL1, MAX, GATA1, ZNF143, HAND2, CBX2, BCL11B, NR2F1, KDM5B, PKNOX1, PHOX2B, AR, ZBTB16, EGLN2, HSF1, BRD4, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): MX1,C2CD2,TMPRSS2,UMODL1,ABCG1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 138

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000157601, ENSG00000184012, ENSG00000157617, ENSG00000177398, ENSG00000160179,

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Deatailed information for cohesin site CDBP00420293