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Basic information

CohesinDB ID: CDBP00420301

Locus: chr21-42290743-42296744

Data sourse: ENCSR000BLD, ENCSR000BTQ, ShirahigeLab-GSE177045, GSE67783, GSE72082, GSE86191, GSE98367, GSE110061, GSE116868, GSE111913, GSE25021, ShirahigeLab, ShirahigeLab-NatGen2015, GSE120943, ENCSR153HNT, ENCSR703TNG, GSE131606, GSE50893, GSE38411

Cell type: MCF-7, GM12892, H1-hESC, Fibroblast, HCT-116, Monocytes, MB157, RPE, GM12878, RT-112, K-562, BCBL-1, HSPC, Macrophage, DKO

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 6% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.833

Subunit: SA1,Rad21,SMC1,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES,Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 88% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 28%, "5_TxWk": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, TRIM25, PGR, ZNF195, ZNF621, MEIS2, NME2, XBP1, FOXA1, SUZ12, RBFOX2, PBX2, ZNF28, ZFHX2, ZBTB7B, TFAP4, HDGF, ZNF274, ATF3, NFIC, BMI1, INSM2, ZNF90, ZBTB5, RUNX3, PRDM1, CHD7, ZNF444, CBFB, PAX5, TP63, BACH2, ZNF467, CDC5L, JMJD1C, MAF, ELF1, TRIM28, BCLAF1, TEAD1, SNAI2, ZNF217, ESR1, MLL, OCA2, USF2, ZIK1, CTCF, TCF12, EP300, E4F1, MNT, GATA6, DPF2, PAX8, IRF4, RAD51, ZNF410, ZNF512B, ZNF776, E2F1, ZNF280A, ZNF175, GTF2F1, PDX1, RBPJ, EED, TFAP2C, GLIS1, JARID2, EHMT2, POU2F2, CHD8, YBX1, NANOG, MYCN, ZNF263, TOP2A, POU5F1, ZNF239, CTBP1, MTA2, ZBTB1, ZBTB48, DUX4, ZSCAN5A, STAT1, ZSCAN21, SRF, NONO, DDX5, NBN, ARID3A, ERG2, HIC1, PHB2, ERG, PBX1, ASCL1, OGG1, MYC, SMARCA4, RFX1, RAD21, GRHL3, NKX2-1, STAT3, ZNF8, XRCC5, NKX3-1, PRDM14, IKZF1, RCOR1, DNMT3B, ZNF639, ZNF398, VDR, NR3C1, CEBPB, ESRRA, HNRNPL, KMT2A, CREB1, ARHGAP35, BMPR1A, GRHL2, GABPB1, PHF8, ZKSCAN5, ZHX2, SPI1, HES1, ZNF257, IRF1, HDAC2, GATA2, INTS13, SSRP1, GATAD2B, MXD3, ZNF182, FLI1, HCFC1, ZNF785, SMARCA5, RELB, ZIM3, NFYB, NCOA2, ATF1, PTBP1, SALL2, ETV5, RUNX1, SMC1A, BCL6, CEBPA, EZH2phosphoT487, NKX2-2, CRY1, CBX1, ZFX, SIN3A, SIRT6, HDAC1, SMAD3, ZNF707, POU4F2, TET2, ZNF770, ERG3, CBX8, ZNF473, TRIM22, ZNF18, PRDM10, MEF2A, CREBBP, RARA, NOTCH1, ZNF384, TAF15, RUNX2, CDK6, OSR2, ZNF184, ARNT, BACH1, CBX3, NFIB, ATF2, PRDM9, PBX3, NCAPH2, FOXM1, ETV6, FOS, CHD1, MED1, ZEB1, TERF1, KDM6B, MYB, ZNF670, ZMYM3, SMAD1, NR1H2, SETDB1, STAT5A, USF1, BCL11A, SP1, NIPBL, GSPT2, PHF20, REST, ZBTB7A, ZNF479, RBM25, ATF7, HNRNPLL, CTBP2, TCF3, BCOR, FOXP1, AATF, SMC3, NCOR2, MLLT1, STAG1, NFATC3, TRP47, CBFA2T2, MEF2B, NCOA4, FOXA2, ZNF207, EBF1, MEIS1, CREM, E2F8, SS18, ZNF600, GTF2B, WT1, MTA3, ZNF662, MEF2C, ZBTB33, CDK9, BCL3, ZKSCAN1, KDM1A, YY1, RELA, TARDBP, ZNF148, AHR, NEUROD1, ZNF266, BRG1, ZNF521, MCM3, SP140, ZFP36, SKIL, HIF1A, ZIC2, TCF4, GATA3, ZNF519, BATF, ZNF311, BHLHE22, MAX, SPIB, GATA1, ZNF143, NRIP1, ZSCAN26, CBX2, PLAG1, TLE3, BCL11B, ZNF592, NCOA3, ZNF544, NR2F1, ZNF768, KDM5B, ZNF791, TP53, PKNOX1, ZNF687, IRF5, ZNF334, BCL6B, EGR2, TBX21, BHLHE40, AR, ZNF445, TAF1, ZBTB40, RXR, RBAK, HEXIM1, RB1, TFIIIC, HSF1, RNF2, IKZF2, BRD4, JUND, EGR1, CLOCK, CUX1, MAZ, ZNF24, ZNF316

Target gene symbol (double-evidenced CRMs): UBASH3A,PDE9A,MX1,PRDM15,ABCG1,UMODL1,TMPRSS2,C2CD2

Function elements

Human SNPs: Gout

Number of somatic mutations (coding): 1392

Number of somatic mutations (non-coding): 95

Related genes and loops

Related gene: ENSG00000157601, ENSG00000184012, ENSG00000141956, ENSG00000157617, ENSG00000177398, ENSG00000160179, ENSG00000160185, ENSG00000160191,

eachgene

Deatailed information for cohesin site CDBP00420301