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Basic information

CohesinDB ID: CDBP00420302

Locus: chr21-42298296-42298540

Data sourse: ENCSR000BSB, GSE108869, ENCSR000ECS, GSE68388

Cell type: HeLa-S3, HCT-116, HuCC-T1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SMC3,Rad21,SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 88% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 40%, "14_ReprPCWk": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, NME2, FOXA1, SUZ12, ZFHX2, HDGF, ATF3, ZFP64, RUNX3, ZSCAN4, CDX2, MAF, JMJD1C, KLF5, ELF1, ZNF121, ESR1, ZNF77, MED26, JUN, CTCF, TCF12, KLF1, LMO1, MNT, PAX8, GTF2F1, TFAP2C, GLIS1, POU2F2, CHD8, NANOG, POU5F1, MYCN, RUNX1T1, ZNF263, ZBTB48, DDX5, ERG2, ERG, OGG1, ZBTB8A, MYC, EOMES, RAD21, GRHL3, PROX1, GABPA, STAT3, DNMT3B, NR3C1, CEBPB, CREB1, SPI1, EHF, GATA2, SSRP1, FLI1, HCFC1R1, PTBP1, RUNX1, CEBPA, CRY1, SIN3A, ZFX, ZNF534, SMAD3, CBX8, ERG3, NOTCH1, RUNX2, SMAD2, ARNT, ATF2, SMAD4, PBX3, SUPT5H, FOS, CHD1, SMARCB1, MYB, SCRT2, HNF4A, ATF7, TCF3, AATF, SMC3, STAG1, ZNF394, TRP47, CBFA2T2, PPARG, SS18, NFATC1, ZNF600, ZNF692, WT1, BCL3, YY1, RELA, JUNB, SP140, ZIC2, TCF4, GATA3, KLF15, TAL1, MAX, GATA1, ZNF143, CBX2, PLAG1, KLF4, SP7, NR2F2, MYOD1, EGR2, ELF3, AR, EGR1, BRD4, SCRT1, MAZ

Target gene symbol (double-evidenced CRMs): UMODL1,UBASH3A,C2CD2,TMPRSS2,PDE9A,PRDM15,MX1,ABCG1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 1

Related genes and loops

Related gene: ENSG00000157601, ENSG00000184012, ENSG00000141956, ENSG00000157617, ENSG00000177398, ENSG00000160179, ENSG00000160185, ENSG00000160191,

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Deatailed information for cohesin site CDBP00420302