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Basic information

CohesinDB ID: CDBP00420304

Locus: chr21-42300983-42302568

Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE67783, GSE86191, GSE98367, GSE101921, ENCSR153HNT, GSE50893, ENCSR917QNE

Cell type: MCF-7, GM12892, HCT-116, HCAEC, K-562, Liver, HSPC, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.911

Subunit: Mau2,SA1,Rad21,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES,Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 88% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 26%, "14_ReprPCWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, ZNF660, SOX2, FOXA1, SUZ12, ZFHX2, TFAP4, LYL1, ZNF90, ATF3, THAP1, CBFB, ZNF273, MECOM, JMJD1C, TEAD1, TRIM28, SNAI2, LMO2, ESR1, JUN, CTCF, TCF12, BAF155, KLF1, MNT, LMO1, GTF2F1, PDX1, TFAP2C, BRD1, MYCN, ZNF263, RUNX1T1, ZBTB48, ERG2, SP4, ERG, PBX1, ASCL1, OGG1, ETS1, MYC, SMARCA4, RAD21, GRHL3, RXRA, GABPA, STAT3, IKZF1, DNMT3B, NR3C1, CEBPB, SRSF3, KMT2A, EZH2, BMPR1A, GRHL2, SPI1, GATA2, MXD3, FLI1, RUNX1, SMC1A, CEBPA, NKX2-2, ZFX, TET2, CBX8, ERG3, PRDM10, CREBBP, ARNT, ATF2, PRDM9, CHD1, SUPT5H, FOS, MYB, NR1H2, KLF9, EVI1, SP1, BCL11A, NR4A1, POU2F3, TCF3, AATF, STAG1, TRP47, FOXA2, SS18, ZSCAN16, WT1, ESR2, HOXB13, KDM1A, YY1, RELA, NEUROD1, BRG1, SP140, TCF4, ZIC2, TAL1, MAX, ZNF449, ZNF333, CBX2, PLAG1, BCL11B, NCOA3, NR2F2, NR2F1, ZNF334, MYOD1, EGR2, AR, RXR, EGR1, HEXIM1, TFIIIC, HSF1, ZBTB26, BRD4, CLOCK, MAZ, AHR

Target gene symbol (double-evidenced CRMs): RSPH1,ABCG1,TMPRSS3,PDE9A,UBASH3A,SLC37A1,WDR4,UMODL1,TMPRSS2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 6

Related genes and loops

Related gene: ENSG00000184012, ENSG00000177398, ENSG00000160179, ENSG00000160183, ENSG00000160185, ENSG00000160188, ENSG00000160190, ENSG00000160191, ENSG00000160193,

eachgene

Deatailed information for cohesin site CDBP00420304