- Basic information
- CohesinDB ID: CDBP00420306
- Locus: chr21-42304539-42307451
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Data sourse: GSE206145-GSE177045, GSE67783, GSE86191, GSE25021, GSE111913, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE83726, GSE116344, GSE131606, GSE50893
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Cell type: MCF-7, RPE, Fibroblast, HCT-116, RH4, GM2610, RT-112, K-562, HSPC, DKO
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.889
- Subunit: SA1,Rad21,SMC1,SA2,Mau2
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES,Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
88% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"14_ReprPCWk": 31%,
"5_TxWk": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, ZNF660, SOX2, FOXA1, SUZ12, ZFHX2, TFAP4, LYL1, ZNF90, ATF3, THAP1, CBFB, ZNF273, MECOM, JMJD1C, TEAD1, TRIM28, SNAI2, LMO2, ESR1, JUN, CTCF, TCF12, BAF155, KLF1, MNT, LMO1, GTF2F1, PDX1, TFAP2C, BRD1, MYCN, ZNF263, RUNX1T1, ZBTB48, ERG2, SP4, ERG, PBX1, ASCL1, OGG1, ETS1, MYC, SMARCA4, RAD21, GRHL3, RXRA, GABPA, STAT3, IKZF1, DNMT3B, NR3C1, CEBPB, SRSF3, KMT2A, EZH2, BMPR1A, GRHL2, SPI1, GATA2, MXD3, FLI1, RUNX1, SMC1A, CEBPA, NKX2-2, ZFX, TET2, CBX8, ERG3, PRDM10, CREBBP, ARNT, ATF2, PRDM9, CHD1, SUPT5H, FOS, MYB, NR1H2, KLF9, EVI1, SP1, BCL11A, NR4A1, POU2F3, TCF3, AATF, STAG1, TRP47, FOXA2, SS18, ZSCAN16, WT1, ESR2, HOXB13, KDM1A, YY1, RELA, NEUROD1, BRG1, SP140, TCF4, ZIC2, TAL1, MAX, ZNF449, ZNF333, CBX2, PLAG1, BCL11B, NCOA3, NR2F2, NR2F1, ZNF334, MYOD1, EGR2, AR, RXR, EGR1, HEXIM1, TFIIIC, HSF1, ZBTB26, BRD4, CLOCK, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): TMPRSS2,RSPH1,WDR4,SLC37A1,PDE9A,UBASH3A,TMPRSS3,UMODL1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 13
- Related genes and loops
- Related gene:
ENSG00000184012,
ENSG00000177398,
ENSG00000160183,
ENSG00000160185,
ENSG00000160188,
ENSG00000160190,
ENSG00000160191,
ENSG00000160193,
- Related loop:
chr21:41450000-41475000~~chr21:42275000-42300000,
chr21:41500000-41525000~~chr21:42300000-42325000,
chr21:41575000-41600000~~chr21:42275000-42300000,
chr21:41600000-41625000~~chr21:42275000-42300000,
chr21:41825000-41850000~~chr21:42275000-42300000,
chr21:41850000-41875000~~chr21:42275000-42300000,
chr21:41900000-41925000~~chr21:42275000-42300000,
chr21:41950000-41975000~~chr21:42275000-42300000,
chr21:42125000-42150000~~chr21:42275000-42300000,
chr21:42125000-42150000~~chr21:42300000-42325000,
chr21:42144411-42146838~~chr21:42302311-42304212,
chr21:42144601-42146847~~chr21:42309014-42310756,
chr21:42144929-42146574~~chr21:42308432-42311039,
chr21:42150000-42175000~~chr21:42275000-42300000,
chr21:42150000-42175000~~chr21:42300000-42325000,
chr21:42262270-42264527~~chr21:42301297-42302783,
chr21:42275000-42300000~~chr21:42425000-42450000,
chr21:42275000-42300000~~chr21:42675000-42700000,
chr21:42275000-42300000~~chr21:42750000-42775000,
chr21:42275000-42300000~~chr21:42775000-42800000,
chr21:42275000-42300000~~chr21:43175000-43200000,
chr21:42300000-42325000~~chr21:42400000-42425000,
chr21:42300000-42325000~~chr21:42425000-42450000,
chr21:42300000-42325000~~chr21:42450000-42475000,
chr21:42300000-42325000~~chr21:42500000-42525000,
chr21:42300000-42325000~~chr21:42525000-42550000,
chr21:42300000-42325000~~chr21:42550000-42575000,
chr21:42300000-42325000~~chr21:42575000-42600000,
chr21:42300000-42325000~~chr21:42750000-42775000,
chr21:42300000-42325000~~chr21:42775000-42800000,
chr21:42300000-42325000~~chr21:42800000-42825000,
chr21:42300000-42325000~~chr21:42850000-42875000,
chr21:42300000-42325000~~chr21:43275000-43300000,
chr21:42308172-42310860~~chr21:42448781-42450921,
chr21:42308252-42310733~~chr21:42380708-42382353,
chr21:42308252-42310733~~chr21:42448842-42450940,
chr21:42308310-42311045~~chr21:42448762-42450961,
chr21:42308397-42310724~~chr21:42448789-42450976,
chr21:42308397-42310785~~chr21:42448830-42450945,
chr21:42308432-42311039~~chr21:42449093-42451498,
chr21:42308453-42310909~~chr21:42449091-42451494,
chr21:42308453-42310909~~chr21:42536570-42538455,
chr21:42308479-42311031~~chr21:42449017-42451480,
chr21:42308480-42310797~~chr21:42380801-42382413,
chr21:42308480-42310797~~chr21:42448856-42450964,
chr21:42308481-42310631~~chr21:42449278-42451482,
chr21:42308486-42310572~~chr21:42380774-42382379,
chr21:42308486-42310572~~chr21:42449084-42450924,
chr21:42308486-42310865~~chr21:42449186-42451455,
chr21:42308487-42310582~~chr21:42449197-42451403,
chr21:42308495-42311005~~chr21:42379115-42382711,
chr21:42308495-42311005~~chr21:42448763-42451324,
chr21:42308500-42310766~~chr21:42449031-42450943,
chr21:42308507-42310972~~chr21:42448353-42451045,
chr21:42308516-42310935~~chr21:42448798-42450961,
chr21:42308523-42310989~~chr21:42448845-42450957,
chr21:42308774-42311038~~chr21:42449078-42451430,
chr21:42308780-42311001~~chr21:42448912-42450945,
chr21:42308939-42310932~~chr21:42449010-42450957,
chr21:42308950-42311048~~chr21:42574252-42575417,
chr21:42308968-42310990~~chr21:42448814-42450934,
chr21:42308984-42310739~~chr21:42449210-42450917,
chr21:42309011-42310797~~chr21:42448842-42450946,
chr21:42309167-42310554~~chr21:42449161-42450786,