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Basic information

CohesinDB ID: CDBP00420307

Locus: chr21-42307683-42313987

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, HUES9, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, HeLa, BGO3, TC-71, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 73% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.178

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 88% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 24%, "14_ReprPCWk": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOXA1, RXRB, KDM3A, ZBTB7B, HDGF, THAP1, PAX5, TEAD1, LMO2, SOX5, DEK, E2F4, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, HHEX, CTBP1, ERF, STAT1, SAP130, ERG, EZH1, SMARCA4, RFX1, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, GATA2, ZNF644, MXD3, SIX2, FLI1, HCFC1, MXI1, DRAP1, NR2C2, RUNX1, HDAC1, NKX2-2, CEBPA, TET2, ZNF654, SP5, TRIM22, SMARCC1, ZBTB2, ZXDC, ATF2, SMARCB1, PIAS1, SMAD1, IKZF5, ARID2, RBM25, MBD2, ELL2, ETV4, CBFA2T2, MEF2B, CREM, CHD2, SS18, WT1, NEUROD1, TCF4, BATF, PLAG1, KLF4, BCL11B, EGR2, ELF3, ARID4B, RXR, EGLN2, HSF1, ZBTB26, NCOR1, SCRT1, ILF3, FOSL1, XBP1, PBX2, TSC22D4, ATF3, ZFP64, RUNX3, CBFB, TP63, MITF, ZNF467, JMJD1C, MAF, MYOG, ELF1, RBM39, CTCF, JUN, LMO1, MNT, RYBP, DPF2, IRF4, PDX1, TFAP2C, RBPJ, MLX, MTA2, ZBTB17, ZBTB48, NONO, SRF, DDX5, NBN, PBX1, ONECUT1, ZNF2, HOMEZ, KDM4A, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, CCAR2, TBL1XR1, GRHL2, EBF3, SMARCA5, NFIL3, THAP11, CTNNB1, SOX13, ZNF770, ARNT, DAXX, ZNF48, PRDM9, PBX3, HMGXB4, TEAD3, U2AF1, USF1, SP1, BCL11A, TFAP2A, ASH2L, CTBP2, GLIS2, SMC3, MLLT1, STAG1, STAG2, TRP47, AGO1, MTA3, EBF1, ZNF580, ZKSCAN1, KDM1A, ZNF19, BRG1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, AGO2, CBX2, TP53, ZNF334, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, RNF2, BRD4, JUND, CUX1, PGR, SOX2, PATZ1, UBTF, TFAP4, CHD7, ZNF444, MXD4, KLF6, NFE2L2, SAP30, ESR1, ZNF217, KLF1, SOX9, E2F6, TRIM24, PRKDC, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, ERG2, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, NKX2-1, GABPA, MCRS1, STAT3, DNMT3B, SRSF3, EZH2, ZNF652, SPI1, PCBP1, HDAC2, NCOA2, ETV5, BCL6, SIN3A, ERG3, CREBBP, ZNF35, RARA, ZNF384, TAF15, NFYC, SMAD4, CDK8, ZMYM3, RBM22, MAFK, HNF4A, REST, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, PPARG, ZNF692, GTF2B, TCF7, FOXO3, RELA, TARDBP, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, PKNOX1, MYOD1, T, AR, HEXIM1, DMAP1, AHR, MBD3, FOSL2, HMG20A, SUZ12, RBFOX2, ZFHX2, ZNF362, CTCFL, PRDM1, HDAC3, CDX2, KLF5, BCLAF1, TRIM28, ETV1, COBLL1, RCOR2, USF2, TCF12, BAF155, EP300, GATA6, ZNF302, GLI4, E2F1, SMC1, FOXA3, ZNF175, BRD1, MYCN, CDK7, RUNX1T1, GATAD1, ARID3A, ASCL1, RAD21, GRHL3, PROX1, XRCC5, ZNF614, NFE2, JMJD6, TRPS1, TFE3, SREBF1, ZGPAT, MRTFB, PTBP1, SMC1A, CBX1, SIRT6, FIP1L1, ZFX, SMAD3, CBX8, TWIST1, NOTCH1, RUNX2, GATA4, NRF1, FOS, CHD1, MED1, CEBPD, MYB, ZNF3, KLF16, NIPBL, ZBTB7A, POU2F3, TCF3, SKI, NELFA, FOXA2, E2F8, ZNF600, MIER2, CDK9, HOXB13, YY1, SP140, HIF1A, ZNF519, ZNF449, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF687, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, CLOCK, MAZ, BRCA1

Target gene symbol (double-evidenced CRMs): RSPH1,WDR4,PDE9A,TMPRSS2,SLC37A1,UBASH3A,TMPRSS3,UMODL1

Function elements

Human SNPs: Parental_longevity_(father's_age_at_death)

Number of somatic mutations (coding): 119

Number of somatic mutations (non-coding): 25

Related genes and loops

Related gene: ENSG00000184012, ENSG00000177398, ENSG00000160183, ENSG00000160185, ENSG00000160188, ENSG00000160190, ENSG00000160191, ENSG00000160193,

eachgene

Deatailed information for cohesin site CDBP00420307