Deatailed information for cohesin site CDBP00420315

Check detailed explainations here

  • Basic information
  • CohesinDB ID: CDBP00420315
  • Locus: chr21-42336026-42341174
  • Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE130140, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE64758, GSE104888, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
  • Cell type: MDM, RH4, GM10847, GM2610, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CUTLL1, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, HeLa, TC-71, Neutrophil, GM18951
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 64% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.222
  • Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intergenic
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 88% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 29%, "14_ReprPCWk": 24%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: MBD3, NFIA, TRIM25, PGR, HMG20A, SOX2, XBP1, FOXA1, SUZ12, PBX2, RXRB, MLL4, HDGF, ATF3, NFIC, ZFP64, THAP1, CHD7, PRDM1, RUNX3, ZNF444, ATF4, CBFB, MECOM, SMARCE1, PAX5, TP63, ZNF320, ZNF736, MAF, JMJD1C, KLF5, TEAD1, TRIM28, ELF1, RBM39, ZNF121, NFE2L2, BCLAF1, ZNF217, ESR1, KLF6, ETV1, OCA2, HDAC8, USF2, CTCF, TCF12, JUN, EP300, BAF155, MNT, ZNF260, SOX5, RYBP, DPF2, E2F6, DMAP1, IRF4, TRIM24, DEK, ZNF398, PRKDC, E2F1, ZNF528, SMC1, NR5A2, TEAD4, FOXA3, ZNF175, GTF2F1, PDX1, TFAP2C, GATAD2A, EED, JARID2, RBPJ, NANOG, POU2F2, CHD8, BRD1, POU5F1, ZNF263, RUNX1T1, MYCN, CTBP1, MTA2, ERF, ZBTB48, STAT1, SRF, GATAD1, SAP130, ERG2, TBP, ERG, HOXC5, ZNF597, NFKB2, ZNF341, ONECUT1, MYC, EZH1, SMARCA4, HOMEZ, RAD21, RFX1, GRHL3, PROX1, NKX2-1, RXRA, BATF3, GABPA, STAT3, XRCC5, ZNF614, NKX3-1, APC, IKZF1, NFE2, MIER3, NR2F6, DACH1, VDR, RCOR1, NR3C1, ESRRA, CEBPB, HNRNPH1, STAT5B, KMT2A, CREB1, CCAR2, EZH2, GRHL2, TRPS1, GABPB1, ZHX2, SPI1, TFE3, MIXL1, IRF1, HDAC2, GATA2, SSRP1, ZNF644, GATAD2B, ZNF146, FLI1, DRAP1, ZGPAT, HCFC1, SMARCA5, ZNF766, NFIL3, NFYB, NCOA2, ATF1, ETV5, RUNX1, THAP11, BCL6, SMC1A, HDAC1, CEBPA, MAFG, NKX2-2, SOX13, AFF4, CBX1, SIN3A, ZFX, SMAD3, NFKBIA, TET2, CBX8, ERG3, TRIM22, SMARCC1, PRDM10, ZNF18, MEF2A, DNMT3B, RARA, NFYC, ZNF35, ZNF384, CREBBP, ZBTB2, ZXDC, CDK6, GATA4, OSR2, RUNX2, ARNT, PBX4, DAXX, ZNF48, HMGB2, SMAD4, ATF2, ETV6, MAFB, FOXM1, FOS, HMGXB4, CDK8, SMARCB1, CHD1, MED1, TEAD3, ZEB1, ZNF264, CEBPD, ZMYM3, PIAS1, SMAD1, ZNF3, NR1H2, L3MBTL2, MBD1, STAT5A, USF1, SP1, NIPBL, MAFK, BCL11A, IRF2, HNF4A, TFAP2A, IKZF5, REST, ARID1A, ZNF479, RBM25, POU2F3, ASH2L, HNRNPLL, CTBP2, PHIP, BCOR, FOXP1, TAF2, MBD2, AATF, SMC3, ELL2, NCOR2, STAG1, MLLT1, NFATC3, SKI, TRP47, MEF2B, PPARG, FOXA2, TBL1X, MTA3, EBF1, CREM, RBBP5, MIER2, GTF2B, WT1, ZBED1, ZNF662, ZBTB33, CDK9, HOXB13, BCL3, ZNF580, KDM1A, YY1, RELA, SIRT6, TARDBP, NEUROD1, JUNB, BRG1, SP140, ZFP36, SKIL, PCGF1, HIF1A, GATA3, BATF, MAX, NRIP1, ZNF143, MTA1, GATA1, CBX2, TLE3, KLF4, CEBPG, ZNF592, NCOA3, GFI1B, NR2F2, ZNF512, NR2F1, TCF7L2, KDM5B, TP53, ZNF687, ZNF334, NFKB1, PHOX2B, ELF3, T, KAT8, ARRB1, TBX21, ARID4B, AR, NFKBIZ, TAF1, ZNF579, EGLN2, RB1, ZBTB26, RNF2, NCOR1, BRD4, ILF3, IKZF2, JUND, CUX1, MAZ, HSF1, CLOCK, ZNF24, AHR
  • Target gene symbol (double-evidenced CRMs): UMODL1,UBASH3A
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 20
  • Related genes and loops
  • Related gene: ENSG00000177398, ENSG00000160185,
  • Related loop: chr21:42144411-42146838~~chr21:42336819-42339025, chr21:42325000-42350000~~chr21:42425000-42450000, chr21:42325000-42350000~~chr21:42800000-42825000, chr21:42335706-42339182~~chr21:42437265-42438562, chr21:42336547-42339124~~chr21:42448845-42450957, chr21:42336747-42338965~~chr21:42448842-42450946, chr21:42336807-42338774~~chr21:42449322-42450806, chr21:42336819-42339025~~chr21:42448763-42451324, chr21:42336829-42338858~~chr21:42448798-42450961, chr21:42336832-42339100~~chr21:42448762-42450961, chr21:42336860-42338813~~chr21:42449084-42450924, chr21:42336860-42339221~~chr21:42448814-42450934, chr21:42336947-42338996~~chr21:42449010-42450957, chr21:42337150-42338850~~chr21:42449091-42451494, chr21:42337183-42339009~~chr21:42448752-42450926, chr21:42337200-42339002~~chr21:42448353-42451045, chr21:42337222-42338891~~chr21:42449125-42450914,
eachgene