Deatailed information for cohesin site CDBP00420323

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  • Basic information
  • CohesinDB ID: CDBP00420323
  • Locus: chr21-42361994-42368140
  • Data sourse: GSE206145-GSE177045, GSE72082, ENCSR404BPV, GSE131606, GSE25021, GSE108869, GSE115602, GSE93080, GSE67783, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, GSE116344, ENCSR703TNG, GSE206145, ENCSR000BMY, ENCSR000BTQ, GSE38395, ENCSR853VWZ, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE50893, ENCSR000ECS
  • Cell type: RH4, GM2610, HuCC-T1, RPE, GM2630, Fibroblast, GM12890, HeLa-S3, hLCL, K-562, GM18486, DKO, SNYDER, GM12878, MCF-7, GM12892, Hela-Kyoto, HCT-116, Hep-G2, Neurons-H1, A-549, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 15% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.756
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS,TES
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 88% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "14_ReprPCWk": 29%, "15_Quies": 26%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, FOXA1, HLF, RXRB, KDM3A, ZBTB7B, HDGF, MEN1, MORC2, PAX5, TEAD1, LMO2, OCA2, SOX5, E2F4, DEK, ZNF528, NR5A2, GATAD2A, NANOG, POU5F1, ZNF263, TOP2A, HHEX, CTBP1, STAT1, SAP130, ERG, SMARCA4, RFX1, RCOR1, NR2F6, CEBPB, CREB1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, SIX2, FLI1, HCFC1, DRAP1, RUNX1, CEBPA, NKX2-2, HDAC1, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ZXDC, SOX11, TFDP1, ATF2, FOXM1, SP2, SMARCB1, PML, PIAS1, SMAD1, NR1H2, C11orf30, MBD1, IKZF5, RBM25, MBD2, ETV4, CBFA2T2, CBX3, ZNF207, CREM, CHD2, NFATC1, WT1, NEUROD1, JUNB, MCM3, ZFP36, BATF, PLAG1, KLF4, ELF3, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, ZNF316, FOSL1, XBP1, PBX2, ATF3, THRB, RUNX3, WDHD1, ZNF467, JMJD1C, ELF1, RBM39, CTCF, JUN, MNT, RYBP, DPF2, IRF4, MED12, DDX20, PDX1, TFAP2C, RBPJ, MLX, MTA2, ZBTB17, ZBTB48, SRF, DDX5, HOMEZ, RXRA, NKX3-1, MIER3, LEF1, VDR, NR3C1, ESRRA, GRHL2, SMARCA5, NFIL3, CC2D1A, THAP11, EZH2phosphoT487, SOX13, ZNF770, ZNF18, CEBPZ, ARNT, NFIB, DAXX, ZNF48, ZEB2, NFYA, HMBOX1, PBX3, MAFB, HMGXB4, TEAD3, DIDO1, U2AF1, KLF9, USF1, BCL11A, TFAP2A, SP1, ATF7, ASH2L, CTBP2, SMC3, STAG1, TRP47, MTA3, EBF1, MAFF, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, BRG1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, MTA1, CBX2, ZNF141, TP53, ZNF334, BRD2, KAT8, RB1, RNF2, IKZF2, BRD4, JUND, CUX1, ZNF468, CBX5, PGR, PATZ1, UBTF, TFAP4, BMI1, ZNF444, ATF4, MXD4, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, TP73, SOX4, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, TBP, HOXC5, OGG1, SMARCC2, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, EZH2, SPI1, HDAC2, GATAD2B, NFYB, NCOA2, ETV5, BCL6, SIN3A, RARA, NFYC, CREBBP, ZNF384, SMAD4, ZNF518A, CBFA2T3, CDK8, ZEB1, ZMYM3, NCOA1, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, PPARG, TBL1X, ZNF662, ZNF574, TCF7, RELA, TARDBP, SKIL, MAX, ZNF592, GFI1B, TCF7L2, NR2F1, KDM5B, PKNOX1, MYOD1, AR, ZNF324, HEXIM1, ZNF280D, AHR, FOSL2, MBD3, HMG20A, MEIS2, SUZ12, ZNF28, NFIC, KLF14, MECOM, HDAC3, CDX2, ZNF506, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, HNF1B, MLL, USF2, TCF12, BAF155, EP300, GATA6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, ZNF425, CHD8, BRD1, MYCN, SRC, RUNX1T1, ID3, GATAD1, ARID3A, ASCL1, ZNF341, RAD21, GRHL3, XRCC5, ZNF614, NFE2, ZNF639, TRPS1, TFE3, ZSCAN2, IRF1, SREBF1, ZGPAT, MRTFB, ATF1, PTBP1, CBX1, SMC1A, SIRT6, ZFX, ZNF534, SMAD3, NOTCH1, RUNX2, CDK6, GATA4, PBX4, FOS, CHD1, MED1, CEBPD, MYB, ZNF3, SETDB1, NIPBL, ZBTB7A, POU2F3, TCF3, FOXA2, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, BRCA1, SP140, HIF1A, OTX2, GATA1, TLE3, CEBPG, NCOA3, NR2F2, ZNF512, ZNF687, NFKBIZ, BHLHE40, TAF1, ZNF579, CLOCK, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): TFF1,TMPRSS3
  • Function elements
  • Human SNPs: Blood_protein_levels
  • Number of somatic mutations (coding): 90
  • Number of somatic mutations (non-coding): 23
  • Related genes and loops
  • Related gene: ENSG00000160182, ENSG00000160183,
  • Related loop: chr21:41650000-41675000~~chr21:42350000-42375000, chr21:42350000-42375000~~chr21:43175000-43200000, chr21:42350000-42375000~~chr21:43200000-43225000, chr21:42350000-42375000~~chr21:43325000-43350000, chr21:42359657-42361508~~chr21:42448798-42450961, chr21:42359709-42361461~~chr21:42448781-42450921, chr21:42359717-42361558~~chr21:42448842-42450946, chr21:42359923-42361354~~chr21:42449161-42450786,
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