- Basic information
- CohesinDB ID: CDBP00420324
- Locus: chr21-42369574-42378333
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Data sourse: ENCSR000BLD, ShirahigeLab-GSE177045, GSE72082, ENCSR000FAD, ENCSR000EGW, GSE105028, GSE121355, GSE131606, GSE25021, GSE115602, ENCSR000EFJ, ENCSR000BTU, GSE139435, ENCSR000DZP, ENCSR000EAC, GSE143937, ENCSR000BKV, GSE67783, GSE86191, GSE93080, GSE76893, GSE101921, ShirahigeLab-NatGen2015, ENCSR703TNG, GSE106870, GSE145327, GSE118494, GSE115248, ENCSR879KXD, ShirahigeLab, ENCSR000ECE, ENCSR000BMY, ENCSR000BTQ, GSE110061, GSE129526, GSE111913, GSE155324, ENCSR153HNT, GSE83726, GSE50893, GSE38411
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Cell type: RH4, GM10847, GM2610, CVB-hiPSC, GM19240, HSPC, CVI-hiPSC, B-cell, H9-hESC, GM2630, RPE, Fibroblast, Ishikawa, Kelly, GM12890, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, H1-hESC, SNYDER, GM18505, Leukemia-SEM, Lymphoblast, GM12878, GM12891, GM2588, GM19239, RT-112, GM19193, GM19099, MCF-7, GM12892, HCT-116, MCF-10A, GM19238, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 25% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.567
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES,Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
88% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"14_ReprPCWk": 28%,
"15_Quies": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, ZNF675, NME2, FOXA1, HLF, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, MEN1, THAP1, PAX5, SFPQ, TEAD1, LMO2, HDAC8, ZNF157, SOX5, DEK, ZNF528, NR5A2, RFX3, GATAD2A, NANOG, ZNF263, POU5F1, TOP2A, HHEX, CTBP1, DUX4, STAT1, SAP130, ERG, SMARCA4, RFX1, FOXK2, ZNF398, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, HCFC1, HCFC1R1, RUNX1, HDAC1, CEBPA, NKX2-2, CRY1, TET2, ZNF473, TBX3, SP5, MCM2, CARM1, TRIM22, SMARCC1, ZNF549, ZBTB2, ZXDC, TFDP1, ATF2, FOXM1, SP2, SMARCB1, PML, PIAS1, SMAD1, C11orf30, EVI1, MBD1, IKZF5, RBM25, MBD2, ETV4, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, CHD2, SS18, WT1, MEF2C, NEUROD1, MCM3, ZFP36, TCF4, ZNF311, MAF1, PLAG1, ZFP69B, BCL11B, KLF4, ZBTB6, EGR2, ELF3, ARID4B, RXR, EGLN2, HSF1, ZBTB26, NCOR1, FOSL1, ZNF621, HNF1A, XBP1, PBX2, HNRNPK, TSC22D4, ATF3, THRB, ZFP64, RUNX3, WDHD1, CBFB, ZNF273, DPF1, TP63, ZSCAN4, MITF, CDC5L, MAF, JMJD1C, ELF1, RBM39, SNAI2, KLF10, CTCF, JUN, L3MBTL4, MNT, DPF2, IRF4, MED12, ZNF280A, PDX1, TFAP2C, RBPJ, MLX, MTA2, ZBTB48, UTX, SRF, PBX1, HOMEZ, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, CCAR2, TBL1XR1, GRHL2, SSRP1, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, SOX13, AFF4, ARNT, NFIB, DAXX, ZNF48, ZEB2, NFYA, PBX3, ETV6, NCAPH2, MAFB, HMGXB4, TEAD3, DIDO1, U2AF1, USF1, BCL11A, SP1, TFAP2A, ZNF479, ATF7, ASH2L, CTBP2, SMC3, MLLT1, STAG1, STAG2, TRP47, AGO1, MTA3, EBF1, MEIS1, MAFF, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, BRG1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, AGO2, MTA1, CBX2, TP53, ZNF334, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, SMAD4.1D12, ZNF468, PGR, SOX2, TFAP4, BMI1, CHD7, ZNF444, ATF4, MXD4, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, SND1, KLF1, SOX9, E2F6, TRIM24, RFX5, PRKDC, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZBTB1, ZSCAN5A, ERG2, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, ARID1B, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, SRSF3, EZH2, ZNF652, SPI1, PCBP1, HDAC2, GATAD2B, NCOA2, ZNF554, SALL2, ETV5, BCL6, SIN3A, ERG3, NFXL1, MEF2A, MYBL2, CREBBP, ZNF384, RARA, NFYC, TAF15, SMAD4, CBFA2T3, CDK8, ZEB1, ZMYM3, NCOA1, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, PPARG, TBL1X, ZNF716, ZNF692, ZNF662, ZNF574, TCF7, FOXO3, RELA, TARDBP, MAX, ZNF592, NR2F1, TCF7L2, KDM5B, PKNOX1, MYOD1, AR, PAX3-FOXO1, YAP1, ZNF324, HEXIM1, AHR, FOSL2, MBD3, DMAP1, HMG20A, MEIS2, SUZ12, RBFOX2, ZFHX2, NFIC, ZBTB5, CTCFL, CDX2, KLF5, BCLAF1, TRIM28, RCOR2, HNF1B, USF2, TCF12, BAF155, EP300, GATA6, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, ZNF425, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, GATAD1, ARID3A, ZNF585B, ASCL1, MCM5, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, ZNF639, JMJD6, TRPS1, HES1, TFE3, HBP1, ZSCAN2, IRF1, SREBF1, ZGPAT, MRTFB, ZIM3, PTBP1, SMC1A, CBX1, FIP1L1, ZFX, ZNF534, SMAD3, CBX8, IRF2, PRPF4, NOTCH1, RUNX2, CDK6, GATA4, NRF1, PBX4, CHD1, FOS, SUPT5H, TGIF2, MED1, KDM6B, MYB, SCRT2, CEBPD, VEZF1, ZNF3, L3MBTL2, SETDB1, NIPBL, PHF20, ZBTB7A, POU2F3, PHIP, TCF3, SKI, ZNF283, FOXA2, RBBP5, ZNF600, MIER2, ZBTB33, CDK9, HOXB13, YY1, ZNF148, SP140, HIF1A, ZNF449, GATA1, TLE3, CEBPG, NCOA3, NR2F2, ZNF687, BHLHE40, NFKBIZ, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, CLOCK, MAZ, ZNF24
- Target gene symbol (double-evidenced CRMs): UMODL1,UBASH3A,TFF1,TMPRSS3
- Function elements
- Human SNPs: Face_memory
- Number of somatic mutations (coding): 588
- Number of somatic mutations (non-coding): 43
- Related genes and loops
- Related gene:
ENSG00000177398,
ENSG00000160182,
ENSG00000160183,
ENSG00000160185,
- Related loop:
chr21:41600000-41625000~~chr21:42375000-42400000,
chr21:41650000-41675000~~chr21:42350000-42375000,
chr21:42125000-42150000~~chr21:42375000-42400000,
chr21:42144207-42146848~~chr21:42380765-42382404,
chr21:42144411-42146838~~chr21:42379115-42382711,
chr21:42144457-42146811~~chr21:42380286-42382659,
chr21:42144599-42146873~~chr21:42380621-42382601,
chr21:42144776-42146791~~chr21:42380859-42382357,
chr21:42144995-42146449~~chr21:42380974-42382225,
chr21:42150000-42175000~~chr21:42375000-42400000,
chr21:42163609-42165687~~chr21:42380859-42382357,
chr21:42163812-42165464~~chr21:42380774-42382379,
chr21:42308252-42310733~~chr21:42380708-42382353,
chr21:42308480-42310797~~chr21:42380801-42382413,
chr21:42308486-42310572~~chr21:42380774-42382379,
chr21:42308495-42311005~~chr21:42379115-42382711,
chr21:42350000-42375000~~chr21:43175000-43200000,
chr21:42350000-42375000~~chr21:43200000-43225000,
chr21:42350000-42375000~~chr21:43325000-43350000,
chr21:42375000-42400000~~chr21:42800000-42825000,
chr21:42376023-42377763~~chr21:42448830-42450945,
chr21:42376040-42377995~~chr21:42448845-42450957,
chr21:42376051-42377691~~chr21:42448842-42450946,
chr21:42376058-42377983~~chr21:42448798-42450961,
chr21:42376165-42377700~~chr21:42449311-42450852,
chr21:42376176-42377607~~chr21:42449161-42450786,
chr21:42376206-42377802~~chr21:42449017-42451480,
chr21:42376251-42377642~~chr21:42449010-42450957,
chr21:42376319-42377570~~chr21:42449201-42450804,
chr21:42379115-42382711~~chr21:42448763-42451324,
chr21:42379115-42382711~~chr21:42536098-42538505,
chr21:42380286-42382659~~chr21:42448861-42450972,
chr21:42380494-42382722~~chr21:42448782-42450960,
chr21:42380494-42382722~~chr21:42535556-42538484,
chr21:42380497-42382547~~chr21:42448828-42450945,
chr21:42380717-42382804~~chr21:42449093-42451498,
chr21:42380746-42382516~~chr21:42449031-42450943,
chr21:42380793-42382292~~chr21:42449091-42451494,
chr21:42380842-42382336~~chr21:42449125-42450914,
chr21:42380859-42382357~~chr21:42448814-42450934,
chr21:42380883-42382301~~chr21:42449239-42450901,
chr21:42380903-42382335~~chr21:42449017-42451480,