- Basic information
- CohesinDB ID: CDBP00420331
- Locus: chr21-42397019-42398856
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Data sourse: GSE67783, ENCSR153HNT, GSE86191
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Cell type: K-562, HCT-116, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.967
- Subunit: SA1,Rad21
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
88% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 41%,
"7_Enh": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, PGR, MEIS2, NME2, FOXA1, RXRB, HDGF, ATF3, THAP1, CTCFL, SMARCE1, TRIM28, NFE2L2, ESR1, OCA2, CTCF, DPF2, E2F6, EHMT2, TFAP2C, POU2F2, CHD8, ZSCAN5D, MYCN, POU5F1, CTBP1, ZBTB48, ZSCAN5A, ERG, PBX1, ASCL1, MYC, SMARCA4, ARID1B, GRHL3, RXRA, GABPA, XRCC5, PRDM14, IKZF1, NFE2, RCOR1, NR2F6, ARNTL, NR3C1, KMT2A, HDAC2, GATA2, SIX2, FLI1, HCFC1R1, ATF1, RUNX1, BCL6, MAFG, SMC1A, EZH2phosphoT487, CBX1, CRY1, ZFX, SMAD4, CBFA2T3, NR2C1, MED1, TEAD3, TERF1, C11orf30, L3MBTL2, BCL11A, GSPT2, POU2F3, HNRNPLL, TCF3, FOXP1, SMC3, MLLT1, STAG1, PPARG, TBL1X, EBF1, WT1, ZBTB33, KDM1A, YY1, RELA, NEUROD1, AHR, SP140, HIF1A, OTX2, GATA3, MGA, TAL1, MAX, ZNF143, GATA1, HAND2, PLAG1, NR2F2, NR2F1, AR, PAX3-FOXO1, ZBTB40, RXR, ZBTB26, RNF2, BRD4, CLOCK, MAZ, ZNF316
- Target gene symbol (double-evidenced CRMs): TMPRSS3,UMODL1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 6
- Related genes and loops
- Related gene:
ENSG00000177398,
ENSG00000160183,
- Related loop:
chr21:41600000-41625000~~chr21:42375000-42400000,
chr21:42125000-42150000~~chr21:42375000-42400000,
chr21:42150000-42175000~~chr21:42375000-42400000,
chr21:42300000-42325000~~chr21:42400000-42425000,
chr21:42375000-42400000~~chr21:42800000-42825000,
chr21:42392339-42394372~~chr21:42422767-42426562,
chr21:42392456-42394336~~chr21:42414406-42416483,
chr21:42392456-42394336~~chr21:42422709-42426547,
chr21:42400000-42425000~~chr21:42500000-42525000,
chr21:42400000-42425000~~chr21:42800000-42825000,