- Basic information
- CohesinDB ID: CDBP00420338
- Locus: chr21-42410755-42412796
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, GSE72082, ENCSR000BSB, ENCSR000EGW, GSE105028, GSE121355, GSE25021, ENCSR000BTU, GSE93080, ENCSR000DZP, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, ENCSR703TNG, GSE116344, ENCSR000EEG, GSE98367, ENCSR000BLS, ENCSR000ECE, ENCSR000BMY, ENCSR000EHX, GSE97394, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE50893, ENCSR000ECS
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Cell type: RH4, GM2610, HuCC-T1, H9-hESC, GM2630, Fibroblast, Ishikawa, HeLa-S3, GM2255, K-562, GM18486, H1-hESC, SNYDER, GM12878, SK-N-SH, Macrophage, HUES64, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, GM19238, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 15% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.744
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES,Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
88% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"14_ReprPCWk": 27%,
"15_Quies": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, TRIM25, ZNF675, NME2, FOXA1, MLL4, ZBTB7B, HDGF, PAX5, OCA2, HDAC8, E4F1, SOX5, ZNF407, DEK, ZNF410, GATAD2A, POU5F1, ZNF263, BRD3, CTBP1, STAT1, SAP130, ERG, ZBTB21, ZNF597, NFKB2, SMARCA4, RFX1, FOXK2, ZNF8, RCOR1, CD74, NFRKB, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, KLF17, MXD3, SIX2, FLI1, HCFC1, ZNF785, RELB, HCFC1R1, RUNX1, HDAC1, CEBPA, ZNF707, CRY1, TET2, TBX3, TRIM22, SMARCC1, PRDM10, ZBTB2, ATF2, FOXM1, SP2, SMARCB1, GMEB1, SMAD1, NR1H2, ARID2, ELL2, NFATC3, CBFA2T2, MEF2B, ZNF207, CREM, CHD2, NFATC1, SS18, ZSCAN16, WT1, MEF2C, JUNB, NEUROD1, MCM3, ZFP36, TCF4, ZNF311, BATF, PLAG1, ZNF544, EGR2, ELF3, HSF1, NCOR1, ZBTB26, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, ZNF621, PBX2, TSC22D4, ATF3, RUNX3, CBFB, ZSCAN4, TP63, MITF, BACH2, CDC5L, JMJD1C, MAF, MYOG, ELF1, RBM39, SNAI2, CTCF, JUN, MNT, DPF2, IRF4, PLRG1, RBPJ, TFAP2C, YBX1, ZSCAN21, ZBTB17, ZBTB48, MTA2, NONO, SRF, DDX5, NBN, PHB2, CHD4, HOMEZ, BATF3, NR3C1, ESRRA, STAT5B, KMT2A, ARHGAP35, SSRP1, ZSCAN29, SMARCA5, NFIL3, ZBTB24, SOX13, AFF4, ZFP3, ZNF18, ARNT, NFIB, BACH1, ZNF48, PRDM9, ZEB2, PBX3, ETV6, HMGXB4, TEAD3, DIDO1, KLF9, USF1, SP1, BCL11A, ATF7, ASH2L, GLIS2, SMC3, STAG1, MLLT1, TRP47, AGO1, MTA3, EBF1, ESR2, ZKSCAN1, BCL3, KDM1A, ZIC2, GATA3, TAL1, NRIP1, ZNF143, AGO2, TP53, ZNF334, NFKB1, PHOX2B, BRD2, TBX21, EGR1, RB1, IKZF2, BRD4, JUND, CUX1, PGR, PATZ1, BMI1, CHD7, ZNF444, ATF4, SMARCE1, NFE2L2, ESR1, SND1, TRIM24, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZBTB1, ASH1L, ZSCAN5A, ERG2, SP4, HIC1, OGG1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, YBX3, EZH2, MRTFA, SPI1, HDAC2, INTS13, GATAD2B, NCOA2, ZNF554, ETV5, BCL6, SIN3A, NFXL1, ERG3, MEF2A, RARA, CREBBP, SMAD4, CDK8, ZEB1, NCOA1, NR4A1, HNF4A, REST, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, GTF2B, ZNF662, RELA, TARDBP, SKIL, MAX, ZNF592, NR2F1, TCF7L2, KDM5B, PKNOX1, MYOD1, PAX3-FOXO1, AR, HEXIM1, AHR, FOSL2, HMG20A, LCORL, SUZ12, ZFHX2, ZNF274, ZNF90, NFIC, ZBTB5, PRDM1, ZNF629, KLF5, BCLAF1, TRIM28, MLL, USF2, TCF12, EP300, RAD51, ZNF512B, E2F1, SMC1, TEAD4, ZNF175, EHMT2, EED, CHD8, MYCN, ID3, ARID3A, ZNF585B, MIER1, ZNF341, RAD21, GRHL3, PROX1, XRCC5, ZNF639, ARNTL, HES1, EHF, IRF1, SREBF1, MRTFB, ATF1, SMC1A, FIP1L1, ZFX, SMAD3, IRF2, BRD9, RUNX2, CDK6, ZNF184, NRF1, NR2C1, SUPT5H, CHD1, FOS, MED1, MYB, HIF2A, NIPBL, ZBTB7A, POU2F3, PHIP, TCF3, FOXA2, E2F8, ZNF600, ZBED1, ZBTB33, CDK9, HOXB13, YY1, SP140, HIF1A, NCOA3, ZNF687, BHLHE40, TAF1, ZBTB40, ZBTB42, MAZ, ZNF24
- Target gene symbol (double-evidenced CRMs): ABCG1,SLC37A1,UBASH3A,RSPH1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 27
- Number of somatic mutations (non-coding): 9
- Related genes and loops