Browse_each

Basic information

CohesinDB ID: CDBP00420342

Locus: chr21-42422915-42428748

Data sourse: ENCSR000BLD, GSE93080, ENCSR000EAC, ENCSR000DZP, GSE67783, GSE73207, GSE86191, GSE98367, GSE155324, GSE206145, GSE206145-NatGen2015, ENCSR000BMY, ENCSR000EDE, GSE120943, GSE68388, GSE83726, GSE25021, GSE50893, GSE94872, ENCSR917QNE

Cell type: RH4, GM10847, GM2610, GM19240, Liver, HuCC-T1, B-cell, GM2630, Fibroblast, GM12890, HeLa-S3, GM2255, GM18486, GM18526, H1-hESC, SNYDER, Monocytes, Lymphoblast, TF-1, GM12878, GM12891, GM2588, GM19239, GM19193, GM19099, Macrophage, MCF-7, GM12892, HCT-116, HUVEC, GM19238, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 10% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.644

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 88% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 24%, "7_Enh": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, HMG20A, FOXA1, HLF, RXRB, MLL4, TFAP4, HDGF, TSC22D4, LYL1, ATF3, NFIC, ZC3H8, ZFP64, BMI1, THRB, RUNX3, ATF4, CBFB, MECOM, PAX5, MAF, MYOG, KLF5, ELF1, BCLAF1, TRIM28, ZNF26, TEAD1, JMJD1C, ZNF217, ESR1, MLL, TP73, LMO2, SMAD5, USF2, CTCF, TCF12, SND1, EP300, ARID5B, BAF155, LMO1, KLF1, SOX5, DPF2, IRF4, TRIM24, RFX5, RAD51, SMC1, FOXA3, GATAD2A, PDX1, RBPJ, EED, TFAP2C, POU2F2, CHD8, ZNF263, MYCN, CDK7, RUNX1T1, MTA2, DUX4, ZBTB48, STAT1, SRF, SAP130, NBN, ERG2, ERG, CHD4, PBX1, ASCL1, NFKB2, ETS1, MYC, SMARCA4, RFX1, RAD21, GRHL3, PROX1, RXRA, GABPA, APC, STAT3, NKX3-1, PRDM14, IKZF1, NFE2, RCOR1, HNRNPH1, NR3C1, CEBPB, STAT5B, KMT2A, CREB1, EZH2, SPI1, KLF17, HDAC2, GATA2, GATAD2B, FLI1, SMARCA5, RELB, HEXIM1-CDK9, MRTFB, RUNX1, MAFG, SMC1A, BCL6, EZH2phosphoT487, CEBPA, NKX2-2, AFF4, ZFX, POU4F2, SIN3A, ERG3, TRIM22, SMARCC1, MEF2A, CREBBP, ZBTB2, NOTCH1, RARA, CDK6, ARNT, NFIB, BACH1, ATF2, ZNF48, SMAD4, FOXM1, PBX3, ETV6, SUPT5H, FOS, CDK8, MAFB, MED1, ZEB1, PML, TEAD3, MYB, ZMYM3, SMAD1, C11orf30, SETDB1, EVI1, STAT5A, MAFK, BCL11A, SP1, NIPBL, HNF4A, NR4A1, FOXA2, REST, RBM25, ATF7, POU2F3, ASH2L, TCF3, BCOR, SMC3, NCOR2, STAG1, MLLT1, NFATC3, SKI, MEF2B, ZNF207, MTA3, EBF1, CREM, SS18, E2F8, MEIS1, NFATC1, GTF2B, WT1, MAFF, ZBED1, JDP2, MIER2, TCF7, CDK9, BCL3, KDM1A, YY1, RELA, TARDBP, NEUROD1, AHR, JUNB, SP140, TCF4, SKIL, HIF1A, ZFP36, OTX2, GATA3, BATF, TAL1, MAX, NRIP1, ZNF143, GATA1, ZFP69B, ZNF592, BCL11B, NCOA3, NR2F2, CEBPG, TCF7L2, NR2F1, NEUROG2, TP53, ZNF687, PKNOX1, MED, NFKB1, EGR2, ELF3, TBX21, BHLHE40, AR, NFKBIZ, TAF1, ZBTB16, ZBTB40, ZNF579, HSF1, RNF2, IKZF2, BRD4, ZBTB26, JUND, MAZ, ZNF24, ZNF316, RUNX1-3

Target gene symbol (double-evidenced CRMs): C2CD2,TMPRSS3,HSF2BP,SLC37A1,UBASH3A,ABCG1,UMODL1,PRDM15,RIPK4,RSPH1,TFF2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 168

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000183421, ENSG00000141956, ENSG00000157617, ENSG00000177398, ENSG00000160179, ENSG00000160181, ENSG00000160183, ENSG00000160185, ENSG00000160188, ENSG00000160190, ENSG00000160207,

eachgene

Deatailed information for cohesin site CDBP00420342