Browse_each

Basic information

CohesinDB ID: CDBP00420348

Locus: chr21-42436840-42441137

Data sourse: GSE93080, GSE206145-GSE177045, ENCSR000EAC, ENCSR000DZP, GSE67783, GSE72082, GSE86191, GSE98367, GSE116868, GSE25021, GSE111913, GSE206145, ENCSR054FKH, ENCSR000BMY, ENCSR153HNT, GSE120943, GSE68388, ENCSR703TNG, GSE131606, GSE50893

Cell type: GM10847, GM2610, GM19240, HuCC-T1, B-cell, GM2630, GM2255, K-562, GM18486, DKO, GM18951, SNYDER, Monocytes, GM18505, MB157, GM12878, GM12891, GM2588, GM19239, RT-112, Macrophage, MCF-7, GM12892, HCT-116, Hep-G2, GM19238, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 10% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.700

Subunit: NIPBL,SA1,Rad21,SMC1,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 88% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 26%, "15_Quies": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, ZNF195, NME2, FOXA1, RXRB, HDGF, THAP1, PAX5, ZNF320, LMO2, E4F1, ZNF157, DEK, E2F4, ZNF410, RFX3, ZNF263, TOP2A, CTBP1, DUX4, STAT1, ZNF488, ERG, ZBTB21, NFKB2, SMARCA4, FOXK2, ZNF8, ZNF398, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, GABPB1, KLF17, ZNF257, GATA2, ZNF644, MXD3, FLI1, HCFC1, ZNF785, RELB, RUNX1, CEBPA, HDAC1, TET2, ZNF473, TRIM22, SMARCC1, PRDM10, ZBTB2, ATF2, FOXM1, SMARCB1, PML, SMAD1, STAT5A, IKZF5, ARID2, RBM25, NFATC3, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, CHD2, NFATC1, SS18, WT1, NEUROD1, JUNB, ZFP36, ZNF311, BATF, ZSCAN26, KLF4, ZNF544, IRF5, ZBTB6, BCL6B, EGR2, ELF3, ARID4B, EGLN2, ZBTB26, NCOR1, HSF1, ILF3, ADNP, ZNF316, FOSL1, ZNF660, ZNF621, XBP1, PBX2, ATF3, RUNX3, CBFB, TP63, ZSCAN4, MITF, CDC5L, MAF, JMJD1C, ELF1, ZNF571, ZIK1, CTCF, JUN, MNT, DPF2, IRF4, ZNF776, PDX1, TFAP2C, RBPJ, YBX1, ZNF239, MTA2, ZBTB17, ZBTB48, NONO, SRF, DDX5, NBN, CHD4, HOMEZ, LEF1, MIER3, NR3C1, ESRRA, TBL1XR1, ARHGAP35, GRHL2, SSRP1, ZSCAN29, SMARCA5, THAP11, LDB1, SOX13, AFF4, ZNF513, ZMIZ1, ZNF18, ARNT, NFIB, BACH1, ZNF48, PRDM9, HMBOX1, ZEB2, PBX3, ETV6, TEAD3, KLF9, USF1, BCL11A, SP1, NKX2-5, ZNF479, ATF7, SMC3, STAG1, MLLT1, ZNF394, MTA3, EBF1, MEIS1, ESR2, BCL3, ZKSCAN1, KDM1A, ZNF266, ZNF155, TAL1, NRIP1, ZNF143, MTA1, ZNF768, TP53, NFKB1, KAT8, TBX21, EGR1, RB1, RNF2, IKZF2, JUND, BRD4, PGR, CBX5, UBTF, BMI1, ZNF444, ATF4, ZNF189, SMARCE1, KLF6, NFE2L2, SAP30, ESR1, ZNF217, SND1, KLF1, E2F6, TRIM24, RFX5, GTF2F1, POU2F2, ZSCAN5D, KDM4C, ZBTB1, ZSCAN5A, ZNF224, ERG2, TBP, HOXC5, SMARCC2, MYC, ARID1B, GABPA, STAT3, IKZF1, YBX3, EZH2, SPI1, HDAC2, GATAD2B, ZNF554, SALL2, BCL6, SIN3A, NFXL1, ERG3, MEF2A, MYBL2, CREBBP, RARA, TAF15, SMAD4, CBFA2T3, ZEB1, ZMYM3, NCOA1, HNF4A, REST, BCOR, FOXP1, TBL1X, ZNF692, GTF2B, ZNF30, ZNF662, ZNF318, RELA, TARDBP, SKIL, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, ZNF791, PKNOX1, AR, ZNF324, ZNF280D, AHR, MEIS2, SUZ12, ZFHX2, NFIC, ZBTB5, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, USF2, TCF12, EP300, BAF155, GATA6, SOX6, ZNF512B, E2F1, TEAD4, EHMT2, EED, CHD8, MYCN, SRC, ID3, GATAD1, ARID3A, MIER1, RAD21, PROX1, XRCC5, NFE2, ZNF639, ZNF750, HES1, TFE3, ATF1, PTBP1, SMC1A, CBX1, ZFX, SMAD3, IRF2, RUNX2, CDK6, GATA4, OSR2, ZNF184, PBX4, NRF1, FOS, SUPT5H, MED1, CEBPD, MYB, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, TCF3, ZNF283, FOXA2, E2F8, MIER2, ZBED1, ZBTB33, HOXB13, YY1, ZNF148, ZNF521, SP140, HIF1A, GATA1, CEBPG, SP7, NCOA3, NR2F2, ZNF687, BHLHE40, TAF1, ZBTB40, MYNN, CLOCK, MAZ

Target gene symbol (double-evidenced CRMs): SLC37A1,HSF2BP,C2CD2,PRDM15,TFF2,UMODL1,ABCG1,RIPK4,UBASH3A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 162

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000183421, ENSG00000141956, ENSG00000157617, ENSG00000177398, ENSG00000160179, ENSG00000160181, ENSG00000160185, ENSG00000160190, ENSG00000160207,

eachgene

Deatailed information for cohesin site CDBP00420348