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Basic information

CohesinDB ID: CDBP00420350

Locus: chr21-42443007-42454584

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, GSE130140, GSE115248, GSE168045, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, ShirahigeLab, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, ShirahigeLab-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, ShirahigeLab-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CUTLL1, CVI-hiPSC, Liver, GP5d, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, HUES9, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, SC, A-549, HUVEC, HCAEC, Ramos, GM19238, HeLa, CNCC-WT33iPSC, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 74% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.144

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES,Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 88% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 22%, "7_Enh": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, SOX2, FOXA1, ZNF90, NFIC, RUNX3, PAX5, ZNF736, MAF, TEAD1, RBM39, SNAI2, ESR1, USF2, CTCF, TCF12, RBPJ, GLIS1, MYCN, ZNF263, RUNX1T1, ID3, ZBTB48, ASCL1, OGG1, MYC, RAD21, GRHL3, XRCC5, CEBPB, EZH2, PHF8, SPI1, GATA2, RUNX1, SMC1A, BCL6, SIRT6, ZFX, TET2, NFIB, ARNT, SOX11, PRDM9, PBX3, SMARCB1, FOS, ZEB1, ZNF3, USF1, ZBTB7A, ZNF479, HNRNPLL, TCF3, AATF, STAG1, TRP47, EBF1, SS18, ZNF600, WT1, ZBTB33, BCL3, YY1, RELA, SP140, ZIC2, BATF, TAL1, MAX, ZNF143, PLAG1, NR2F1, NFKB1, BHLHE40, AR, RXR, HEXIM1, HSF1, NCOR1, BRD4, MAZ, AHR

Target gene symbol (double-evidenced CRMs): ABCG1,RIPK4,HSF2BP,TFF2,UMODL1,TMPRSS3,TFF1,SLC37A1,UBASH3A,C2CD2,PRDM15

Function elements

Human SNPs: .

Number of somatic mutations (coding): 347

Number of somatic mutations (non-coding): 65

Related genes and loops

Related gene: ENSG00000183421, ENSG00000141956, ENSG00000157617, ENSG00000177398, ENSG00000160179, ENSG00000160181, ENSG00000160182, ENSG00000160183, ENSG00000160185, ENSG00000160190, ENSG00000160207,

eachgene

Deatailed information for cohesin site CDBP00420350